Results 81 to 90 of about 40,852 (216)

Acupuncture protects against cerebral ischemia–reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis

Molecular Medicine, 2020
Background Acupuncture treatment possesses the neuroprotection potential to attenuate cerebral ischemia–reperfusion (I/R) injury. Endoplasmic reticulum (ER) stress has been suggested to be involved in the pathogenic mechanism of cerebral I/R injury ...
Xiaowei Sun, Hao Liu, Zhongren Sun, Beng Zhang, Xinyu Wang, Tingting Liu, Tingting Pan, Ying Gao, Xicheng Jiang, Hongtao Li   +9 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Mechanisms linking glucotoxicity to the development of insulin resistance: a role for the endoplasmic reticulum stress

, 2010
Aims/hypothesis: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. Here we sought to evaluate the possible role of ER stress in the induction of insulin-resistance by glucosamine in skeletal muscle cells. Methods:
Iadicicco, Claudia
core  

Exploring Endocannabinoid System: Unveiling New Roles in Modulating ER Stress [PDF]

The endoplasmic reticulum (ER) is the organelle mainly involved in maintaining cellular homeostasis and driving correct protein folding. ER-dependent defects or dysfunctions are associated with the genesis/progression of several pathological conditions ...
Alessia Bertamino, Miranda, Maria Rosaria, Ostacolo, Carmine, Pietro Campiglia and Tania Ciaglia, Tania Ciaglia, Michele Manfra, Musella, Simona, Di Sarno, Veronica, Manfra, Michele, Carmine Ostacolo, Ilaria Capolupo, Simona Musella, Pietro Campiglia, Veronica Di Sarno, Bertamino, Alessia, Campiglia, Pietro, Ciaglia, Tania, Maria Rosaria Miranda, Capolupo, Ilaria   +18 more
core   +1 more source

Molecular mechanisms of ER stress and UPR in the pathogenesis of Alzheimer's disease

, 2020
Alzheimer’s disease (AD) is a progressive neurodegenerative disease involving aggregation of misfolded proteins inside the neuron causing prolonged cellular stress.
Barreto, George E, Sharma, Gaurav, Ashraf, Ghulam Md, Perveen, Asma, Uddin, Md Sahab, Kabir, Md Tanvir, Tewari, Devesh, Bin-Jumah, May N, Abdel-Daim, Mohamed M   +8 more
core   +1 more source

Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury

Mediators of Inflammation, 2018
Background. Sepsis leads to severe acute lung injury/acute respiratory distress syndrome (ALI/ARDS) that is associated with enhanced endoplasmic reticulum (ER) stress.
Xiaozhen Chen, Yinglin Wang, Xiang Xie, Hongfei Chen, Qiqi Zhu, Zhidong Ge, Hua Wei, Jingshong Deng, Zhengyuan Xia, Qingquan Lian   +9 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Factor analysis of posttraumatic stress disorder symptoms using data pooled from two venlafaxine extended-release clinical trials

, 2013
BACKGROUND: Confirmatory factor analysis (CFA) of Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV) three-factor posttraumatic stress disorder (PTSD) diagnostic criteria was conducted to determine fit for this patient ...
Stein, Dan J, Jonathan R. T. Davidson, Stein, D.J., Davidson, J.R.T., Rothbaum, Barbara O, Davidson, Jonathan RT, Pedersen, R., Baldwin, D.S., Szumski, Annette, Pedersen, Ronald, Dan J. Stein, Rothbaum, B.O., David S. Baldwin, Barbara O. Rothbaum, Annette Szumski, Baldwin, David S, Ronald Pedersen, Szumski, A.   +17 more
core   +1 more source

Free fatty acids induce apoptosis in mammary epithelial cells from ketotic dairy cows via endoplasmic reticulum stress

Journal of Integrative Agriculture
The mammary glands of dairy cows with ketosis face unique challenges, including the supraphysiological circulating concentrations of free fatty acids (FFA) and apoptosis of epithelial cells.
Renxu Chang, Yuanyuan Chen, Xinyi Xu, Hongdou Jia, John Mauck, Juan J. Loor, Yehoshav A. Ben Meir, Qiushi Xu, Xudong Sun, Chuang Xu   +9 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source