Results 1 to 10 of about 8,105,112 (196)

Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER

Cell Reports
Summary: Despite the consensus that accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen, i.e. ER stress, activates the unfolded protein response (UPR), studies under physiological and pathophysiological conditions suggest that ER ...
Fenfen Xu, Likun Wang
doaj   +2 more sources

Using Arabidopsis Mesophyll Protoplasts to Study Unfolded Protein Response Signaling [PDF]

Bio-Protocol, 2018
Various environmental stresses or artificial reagents can trigger unfolded protein accumulation in the endoplasmic reticulum (ER) due to the folding capacity of the ER being exceeded.
Yan Bao, Diane Bassham
doaj   +2 more sources

The unfolded protein response in multiple sclerosis

Frontiers in Neuroscience, 2015
The unfolded protein response (UPR) occurs in response to endoplasmic reticulum (ER) stress caused by the accumulation of unfolded or misfolded proteins in the ER.
Wensheng eLin, Sarrabeth eStone
doaj   +2 more sources

Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells [PDF]

International Journal of Molecular Sciences, 2019
Wen-Tsan Chang, I-Ling Lin, Chien-chih Chiu   +2 more
exaly   +2 more sources

A small molecule UPR modulator for diabetes identified by high throughput screening

Acta Pharmaceutica Sinica B, 2021
Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the ...
Valeria Marrocco, Tuan Tran, Siying Zhu, Seung Hyuk Choi, Ana M. Gamo, Sijia Li, Qiangwei Fu, Marta Diez Cunado, Jason Roland, Mitch Hull, Van Nguyen-Tran, Sean Joseph, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay, Weijun Shen   +15 more
doaj   +1 more source

Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in Mammalian Oocyte Maturation and Preimplantation Embryo Development [PDF]

International Journal of Molecular Sciences, 2019
Dong Il Jin, Jae Eun Lee
exaly   +2 more sources

ROS and Endoplasmic Reticulum Stress in Pulmonary Disease

Frontiers in Pharmacology, 2022
Pulmonary diseases are main causes of morbidity and mortality worldwide. Current studies show that though specific pulmonary diseases and correlative lung-metabolic deviance own unique pathophysiology and clinical manifestations, they always tend to ...
Xiangning Cui, Yang Zhang, Yingdong Lu, Mi Xiang   +3 more
doaj   +1 more source

The unfolded protein response

, 2006
The unfolded protein response (UPR) is a signal transduction network activated by inhibition of protein folding in the endoplasmic reticulum (ER).
Schröder, M.
core   +6 more sources

Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases

Frontiers in Immunology, 2020
The endoplasmic reticulum (ER) is the major organelle in the cell for protein folding and plays an important role in cellular functions. The unfolded protein response (UPR) is activated in response to misfolded or unfolded protein accumulation in the ER.
Ji-Ae Choi, Ji-Ae Choi, Ji-Ae Choi, Chang-Hwa Song, Chang-Hwa Song, Chang-Hwa Song   +5 more
doaj   +1 more source

Crosstalk Between ER Stress, Autophagy and Inflammation

Frontiers in Medicine, 2021
The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but also plays a critical role in sensing cellular stress and maintaining cellular homeostasis.
Sandhya Chipurupalli, Unni Samavedam, Nirmal Robinson   +2 more
doaj   +1 more source