Results 1 to 10 of about 1,858 (50)
A small molecule UPR modulator for diabetes identified by high throughput screening
Acta Pharmaceutica Sinica B, 2021 Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the ...
Valeria Marrocco +15 more
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ROS and Endoplasmic Reticulum Stress in Pulmonary Disease
Frontiers in Pharmacology, 2022 Pulmonary diseases are main causes of morbidity and mortality worldwide. Current studies show that though specific pulmonary diseases and correlative lung-metabolic deviance own unique pathophysiology and clinical manifestations, they always tend to ...
Xiangning Cui +3 more
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Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases
Frontiers in Immunology, 2020 The endoplasmic reticulum (ER) is the major organelle in the cell for protein folding and plays an important role in cellular functions. The unfolded protein response (UPR) is activated in response to misfolded or unfolded protein accumulation in the ER.
Ji-Ae Choi +5 more
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Crosstalk Between ER Stress, Autophagy and Inflammation
Frontiers in Medicine, 2021 The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but also plays a critical role in sensing cellular stress and maintaining cellular homeostasis.
Sandhya Chipurupalli +2 more
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The Unfolded Protein Response: An Overview
Biology, 2021 The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UPR ...
Adam Read, Martin Schröder
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Nature Communications, 2022 Endoplasmic reticulum stress activates the unfolded protein response (UPR). The authors show that glucose extends the lifespan of aged animals by activating the otherwise quiescent UPR while causing a UPR-dependent reduced longevity in young ...
Caroline Beaudoin-Chabot +9 more
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Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. [PDF]
PLoS Biology, 2004 Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates between the ER and the nucleus.
Christopher K Patil +2 more
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Journal of Pharmacological Sciences, 2009 Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway.
Worapat Prachasilchai +6 more
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Endoplasmic reticulum stress and liver diseases
Liver Research, 2019 Endoplasmic reticulum (ER) stress occurs when ER homeostasis is perturbed with accumulation of unfolded/misfolded protein or calcium depletion. The unfolded protein response (UPR), comprising of inositol-requiring enzyme 1α (IRE1α), double-stranded RNA ...
Xiaoying Liu, Richard M. Green
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Nature Communications, 2022 Endoplasmic Reticulum stress induces cell non-autonomous Unfolded Protein Response (UPR) activation. Here the authors show that long-chain ceramides are secreted from muscle cells in extracellular vesicles and induce cell non-autonomous UPR activation in
Ben D. McNally +15 more
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