Avaliação da ativação da via UPR (Unfolded Protein Response) em células de indivíduos HIV positivos sob diferentes esquemas terapêuticos [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em BiotecnologiaA via UPR (do inglês Unfolded Protein Response) é uma resposta celular ao acúmulo de proteínas desenoveladas no ...
Borsa, Mariana
core
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling [PDF]
, 2012 Many cellular processes including apoptosis, autophagy, translation, energy metabolism, and inflammation are controlled by the mammalian target of rapamycin (mTOR) kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded ...
Appenzeller-Herzog, Christian +1 more
core +1 more source
The physiological role of the unfolded protein response in the nervous system
Neural Regeneration ResearchThe unfolded protein response (UPR) is a cellular stress response pathway activated when the endoplasmic reticulum, a crucial organelle for protein folding and modification, encounters an accumulation of unfolded or misfolded proteins.
Shuangchan Wu, Wensheng Lin
doaj +1 more source
The Role of Endoplasmic Reticulum Stress Response in Pollen Development and Heat Stress Tolerance
Frontiers in Plant Science, 2021 Endoplasmic reticulum (ER) stress is defined by a protracted disruption in protein folding and accumulation of unfolded or misfolded proteins in the ER.
Mohan B. Singh +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Avaliação da transcrição de grp78/bip em células de indivíduos HIV positivos sob diferentes esquemas terapêuticos [PDF]
, 2014 TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.retículo endoplasmático é responsável pela síntese, dobramento e algumas modificações de proteínas que serão secretadas ou proteínas de membrana.
Dahmer, Mariane
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Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Avaliação da ativação da via UPR e do perfil de citocinas séricas em indivíduos HIV soropositivos [PDF]
, 2012 TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.A via UPR (do inglês Unfolded Protein Response) é uma resposta celular ao estresse causado pelo acúmulo de proteínas desenoveladas no retículo endoplasmático.
Tonello, Yuri Tonello
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Unfolded Protein Responses With or Without Unfolded Proteins?
Cells, 2012 The endoplasmic reticulum (ER) is the site of secretory protein biogenesis. The ER quality control (QC) machinery, including chaperones, ensures the correct folding of secretory proteins.
Erik L. Snapp
doaj +1 more source
Advanced Science, EarlyView.QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li +9 more
wiley +1 more source