Results 41 to 50 of about 33,130 (117)
Cytomegalovirus downregulates IRE1 to repress the unfolded protein response. [PDF]
PLoS Pathogens, 2013 During viral infection, a massive demand for viral glycoproteins can overwhelm the capacity of the protein folding and quality control machinery, leading to an accumulation of unfolded proteins in the endoplasmic reticulum (ER). To restore ER homeostasis,
Sebastian Stahl +9 more
doaj +1 more source
Cells, 2018 Eukaryotic cells have evolved signalling pathways that allow adaptation to harmful conditions that disrupt endoplasmic reticulum (ER) homeostasis.
Mariana Hernández-Elvira +7 more
doaj +1 more source
Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response
International Journal of Cell Biology, 2010 The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and activate a set of signaling ...
Afshin Samali +3 more
doaj +1 more source
Frontiers in Endocrinology, 2018 Cells react to a variety of stresses, including accumulation of unfolded or misfolded protein, by activating the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR).
Mara Livezey +3 more
doaj +1 more source
Unfolding the role of stress response signaling in endocrine resistant breast cancers
Frontiers in Oncology, 2015 The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding.
Robert eClarke, Katherine L Cook
doaj +1 more source
Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes
Journal of Diabetes Research, 2014 Pancreatic β cell failure leads to diabetes development. During disease progression, β cells adapt their secretory capacity to compensate the elevated glycaemia and the peripheral insulin resistance.
Nabil Rabhi +3 more
doaj +1 more source
Systemic signaling contributes to the unfolded protein response of the plant endoplasmic reticulum
Nature Communications, 2018 The unfolded protein response (UPR) maintains cellular function under ER stress. While typically considered cell autonomous, here Lai et al. show that in Arabidopsis the UPR also has a systemic component triggered by intercellular movement of at least ...
Ya-Shiuan Lai +5 more
doaj +1 more source
Identification of novel components of the Unfolded Protein Response in Arabidopsis
Frontiers in Plant Science, 2016 Unfavorable environmental and developmental conditions may cause disturbances in protein folding in the endoplasmic reticulum (ER) that are recognized and counteracted by components of the Unfolded Protein Response (UPR) signaling pathways.
Amir eHossain +6 more
doaj +1 more source
PERK and filamin A in actin cytoskeleton remodeling at ER-plasma membrane contact sites
Molecular & Cellular Oncology, 2017 The endoplasmic reticulum (ER) stress sensor protein kinase RNA-like endoplasmic reticulum kinase (PERK) plays a major role during the unfolded protein response (UPR), mainly through eIF2α phosphorylation.
Alexander R. van Vliet +1 more
doaj +1 more source
The Role of the Hypoxia-Related Unfolded Protein Response (UPR) in the Tumor Microenvironment. [PDF]
Cancers (Basel), 2022 Bartoszewska S +2 more
europepmc +1 more source