Results 61 to 70 of about 8,105,112 (196)
Ethanol: response and mechanisms in Caenorhabditis elegans
, 2011 The aim of this project is to identify behavioural phenotypes associated with ethanol in C. elegans and potential molecular targets for ethanol that underpin an ethanol response. This will be achieved through a multi-lateral approach using bioinformatics,
Ient, Ben
core +1 more source
Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response. [PDF]
PLoS Genetics, 2013 Disturbance of cellular functions results in the activation of stress-signaling pathways that aim at restoring homeostasis. We performed a genome-wide screen to identify components of the signal transduction of the mitochondrial unfolded protein response
Eva D Runkel +3 more
doaj +1 more source
The mutualistic fungus Piriformospora indica colonizes Arabidopsis roots by inducing an endoplasmic reticulum stress-triggered caspase-dependent cell death [PDF]
, 2012 In Arabidopsis thaliana roots, the mutualistic fungus Piriformospora indica initially colonizes living cells, which die as the colonization proceeds. We aimed to clarify the molecular basis of this colonization-associated cell death.
Zechmann, B. +4 more
core +1 more source
The unfolded protein response signaling pathways in molluscs
Invertebrate Survival Journal, 2018 Unfolded protein response (UPR) as collective signal transduction pathways is essential for surviving the endoplasmic reticulum (ER) stress in vertebrates and invertebrates.
Y Huang, J Sun, L Wang, L Song
doaj
Animal Research and One Health, EarlyView.Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi +15 more
wiley +1 more source
Dual role for the unfolded protein response in the ovary: adaption and apoptosis
Protein & Cell, 2016 The endoplasmic reticulum (ER) is the principal organelle responsible for several specific cellular functions including synthesis and folding of secretory or membrane proteins, lipid metabolism, and Ca2+ storage.
Ning Huang, Yang Yu, Jie Qiao
doaj +1 more source
Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome
Arthritis &Rheumatology, EarlyView.Objective VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani +10 more
wiley +1 more source
Dynamics in unfolded polypeptide chains as model for elementary steps in protein folding [PDF]
, 2004 This thesis deals with the dynamics of unfolded polypeptide chains as model for the earliest steps in protein folding. Starting from an ensemble of unfolded conformations a folding polypeptide chain has to form specific backbone and side-chain ...
Krieger, Florian
core +1 more source
Endoplasmic reticulum stress as target for treatment of hearing loss
STEMedicine, 2020 The endoplasmic reticulum (ER) plays pivotal roles in coordinating protein biosynthesis and processing. Under ER stress, when excessive misfolded or unfolded proteins are accumulated in the ER, the unfolded protein response (UPR) is activated.
Yanfei Wang, Zhigang Xu
doaj +1 more source
Biological Reviews, EarlyView.ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley +1 more source