Results 1 to 10 of about 79,883 (70)

The H2TH-like motif of the Escherichia coli multifunctional protein KsgA is required for DNA binding involved in DNA repair and the suppression of mutation frequencies

Genes and Environment, 2023
Background DNA oxidatively damaged by reactive oxygen species is repaired by base excision repair (BER) pathway proteins, with DNA glycosylases removing damaged or mismatched bases in the first step of BER. KsgA is a multifunctional protein that exhibits
Yuichiro Hayashi, Masafumi Funakoshi, Kaname Hirosawa, Qiu-Mei Zhang-Akiyama   +3 more
doaj   +1 more source

Rapid detection of single nucleotide polymorphisms using the MinION nanopore sequencer: a feasibility study for perioperative precision medicine

JA Clinical Reports, 2022
Introduction Precision medicine is a phrase used to describe personalized medical care tailored to specific patients based on their clinical presentation and genetic makeup.
Yoshiteru Tabata, Yoshiyuki Matsuo, Yosuke Fujii, Atsufumi Ohta, Kiichi Hirota   +4 more
doaj   +1 more source

Using nanopore sequencing to identify fungi from clinical samples with high phylogenetic resolution

Scientific Reports, 2023
The study of microbiota has been revolutionized by the development of DNA metabarcoding. This sequence-based approach enables the direct detection of microorganisms without the need for culture and isolation, which significantly reduces analysis time and
Atsufumi Ohta, Kenichiro Nishi, Kiichi Hirota, Yoshiyuki Matsuo   +3 more
doaj   +1 more source

CdTe-QDs Affect Reproductive Development of Plants through Oxidative Stress

Toxics, 2023
With the continuous development of industry, an increasing number of nanomaterials are widely used. CdTe-QDs is a nanomaterial with good optical properties, but its release into the natural environment may pose a potential threat.
Jianhua Wang, Yan Gong, Xiaoyan Yan, Rong Han, Huize Chen   +4 more
doaj   +1 more source

Ultrasound and Transcriptomics Identify a Differential Impact of Cisplatin and Histone Deacetylation on Tumor Structure and Microenvironment in a Patient-Derived In Vivo Model of Gastric Cancer

Pharmaceutics, 2021
The reasons behind the poor efficacy of transition metal-based chemotherapies (e.g., cisplatin) or targeted therapies (e.g., histone deacetylase inhibitors, HDACi) on gastric cancer (GC) remain elusive and recent studies suggested that the tumor ...
Aina Venkatasamy, Eric Guerin, Anais Blanchet, Christophe Orvain, Véronique Devignot, Matthieu Jung, Alain C. Jung, Marie-Pierre Chenard, Benoit Romain, Christian Gaiddon, Georg Mellitzer   +10 more
doaj   +1 more source

Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro

Medicina, 2022
Background and Objectives: Clinically used concentrations of sevoflurane, an inhaled anesthetic, have been reported to significantly inhibit tumor growth.
Tomohiro Shoji, Mikio Hayashi, Chisato Sumi, Munenori Kusunoki, Takeo Uba, Yoshiyuki Matsuo, Kiichi Hirota   +6 more
doaj   +1 more source

Hormetic effects of mild heat stress on the primary culture of mouse prefrontal cerebrocortical neurons

Journal of Basic and Applied Zoology, 2020
Background Hormesis is an adaptive response of a biological system to low dose of stressors. It exerts beneficial effects to enable the cells and organisms to sustain the unfavourable conditions.
Narayan R. Mane, Kavita A. Gajare, Ashish A. Deshmukh   +2 more
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CiAPEX2 and CiP0, candidates of AP endonucleases in Ciona intestinalis, have 3′-5′ exonuclease activity and contribute to protection against oxidative stress

Genes and Environment, 2017
Apurinic/apyrimidinic (AP) sites are one of the most frequent DNA lesions. AP sites inhibit transcription and DNA replication, and induce cell death. AP endonucleases are key enzymes in AP site repair. Several types of AP endonucleases have been reported,
Masafumi Funakoshi, Daisuke Nambara, Yuichiro Hayashi, Qiu-Mei Zhang-Akiyama   +3 more
doaj   +1 more source

Effects of single- and mixed-bacterial inoculation on the colonization and assembly of endophytic communities in plant roots

Frontiers in Plant Science, 2022
The introduction and inoculation of beneficial bacteria in plants have consistently been considered as one of the most important ways to improve plant health and production.
Ting Zhang, Juan Xiong, Rongchuan Tian, Ye Li, Qinyi Zhang, Ke Li, Xiaohong Xu, Lianming Liang, Yi Zheng, Baoyu Tian   +9 more
doaj   +1 more source

Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris

Microbial Cell Factories, 2018
Background Proprotein convertase furin is responsible for the processing of a wide variety of precursors consisted of signal peptide, propeptide and mature peptide in mammal.
Yide Huang, Yanyu Long, Suhuan Li, Ting Lin, Jingwen Wu, Yafei Zhang, Yao Lin   +6 more
doaj   +1 more source