Results 1 to 10 of about 1,970,659 (268)

The integrated stress response [PDF]

EMBO Reports, 2016
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2¿) by one of four members of the eIF2¿ kinase family, which leads to a ...
Izabela Koryga, Adrienne Gorman, A Samali   +2 more
exaly   +5 more sources

The H2TH-like motif of the Escherichia coli multifunctional protein KsgA is required for DNA binding involved in DNA repair and the suppression of mutation frequencies

Genes and Environment, 2023
Background DNA oxidatively damaged by reactive oxygen species is repaired by base excision repair (BER) pathway proteins, with DNA glycosylases removing damaged or mismatched bases in the first step of BER. KsgA is a multifunctional protein that exhibits
Yuichiro Hayashi, Masafumi Funakoshi, Kaname Hirosawa, Qiu-Mei Zhang-Akiyama   +3 more
doaj   +1 more source

Rapid detection of single nucleotide polymorphisms using the MinION nanopore sequencer: a feasibility study for perioperative precision medicine

JA Clinical Reports, 2022
Introduction Precision medicine is a phrase used to describe personalized medical care tailored to specific patients based on their clinical presentation and genetic makeup.
Yoshiteru Tabata, Yoshiyuki Matsuo, Yosuke Fujii, Atsufumi Ohta, Kiichi Hirota   +4 more
doaj   +1 more source

Using nanopore sequencing to identify fungi from clinical samples with high phylogenetic resolution

Scientific Reports, 2023
The study of microbiota has been revolutionized by the development of DNA metabarcoding. This sequence-based approach enables the direct detection of microorganisms without the need for culture and isolation, which significantly reduces analysis time and
Atsufumi Ohta, Kenichiro Nishi, Kiichi Hirota, Yoshiyuki Matsuo   +3 more
doaj   +1 more source

Response to Hyperosmotic Stress [PDF]

Genetics, 2012
Abstract An appropriate response and adaptation to hyperosmolarity, i.e., an external osmolarity that is higher than the physiological range, can be a matter of life or death for all cells. It is especially important for free-living organisms such as the yeast Saccharomyces cerevisiae.
Saito, Haruo, Posas Garriga, Francesc
openaire   +2 more sources

CdTe-QDs Affect Reproductive Development of Plants through Oxidative Stress

Toxics, 2023
With the continuous development of industry, an increasing number of nanomaterials are widely used. CdTe-QDs is a nanomaterial with good optical properties, but its release into the natural environment may pose a potential threat.
Jianhua Wang, Yan Gong, Xiaoyan Yan, Rong Han, Huize Chen   +4 more
doaj   +1 more source

Ultrasound and Transcriptomics Identify a Differential Impact of Cisplatin and Histone Deacetylation on Tumor Structure and Microenvironment in a Patient-Derived In Vivo Model of Gastric Cancer

Pharmaceutics, 2021
The reasons behind the poor efficacy of transition metal-based chemotherapies (e.g., cisplatin) or targeted therapies (e.g., histone deacetylase inhibitors, HDACi) on gastric cancer (GC) remain elusive and recent studies suggested that the tumor ...
Aina Venkatasamy, Eric Guerin, Anais Blanchet, Christophe Orvain, Véronique Devignot, Matthieu Jung, Alain C. Jung, Marie-Pierre Chenard, Benoit Romain, Christian Gaiddon, Georg Mellitzer   +10 more
doaj   +1 more source

Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro

Medicina, 2022
Background and Objectives: Clinically used concentrations of sevoflurane, an inhaled anesthetic, have been reported to significantly inhibit tumor growth.
Tomohiro Shoji, Mikio Hayashi, Chisato Sumi, Munenori Kusunoki, Takeo Uba, Yoshiyuki Matsuo, Kiichi Hirota   +6 more
doaj   +1 more source

Hormetic effects of mild heat stress on the primary culture of mouse prefrontal cerebrocortical neurons

Journal of Basic and Applied Zoology, 2020
Background Hormesis is an adaptive response of a biological system to low dose of stressors. It exerts beneficial effects to enable the cells and organisms to sustain the unfavourable conditions.
Narayan R. Mane, Kavita A. Gajare, Ashish A. Deshmukh   +2 more
doaj   +1 more source

The Aging Stress Response [PDF]

Molecular Cell, 2010
Aging is the outcome of a balance between damage and repair. The rate of aging and the appearance of age-related pathology are modulated by stress response and repair pathways that gradually decline, including the proteostasis and DNA damage repair networks and mitochondrial respiratory metabolism.
Haigis, Marcia C., Yankner, Bruce A.
openaire   +2 more sources