Results 41 to 50 of about 9,396,325 (306)

The human stress response [PDF]

Nature Reviews Endocrinology, 2019
The human stress response has evolved to maintain homeostasis under conditions of real or perceived stress. This objective is achieved through autoregulatory neural and hormonal systems in close association with central and peripheral clocks. The hypothalamic-pituitary-adrenal axis is a key regulatory pathway in the maintenance of these homeostatic ...
Georgina Russell, Stafford Lightman
openaire   +4 more sources

Daily life stress and the cortisol awakening response: testing the anticipation hypothesis [PDF]

, 2012
The cortisol awakening response (CAR) is a distinct facet of the circadian cortisol rhythm associated with various health conditions and risk factors.
Schlotz, Wolff, Daniel J Powell, Wolff Schlotz, Schlotz, W., Powell, Daniel J., Powell, D., Powell Daniel J., Schlotz Wolff, Powell, Daniel J   +8 more
core   +2 more sources

Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase

mBio, 2019
Type II toxin-antitoxin (TA) modules encode a stable toxin that inhibits cell growth and an unstable protein antitoxin that neutralizes the toxin by direct protein-protein contact.
Stine Vang Nielsen, Kathryn Jane Turnbull, Mohammad Roghanian, Rene Bærentsen, Maja Semanjski, Ditlev E. Brodersen, Boris Macek, Kenn Gerdes   +7 more
doaj   +1 more source

Critical Care Demand and Intensive Care Supply for Patients in Japan with COVID-19 at the Time of the State of Emergency Declaration in April 2020: A Descriptive Analysis

Medicina, 2020
Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic is overwhelming Japan’s intensive care capacity. This study aimed to determine the number of patients with COVID-19 who required intensive care and to compare the numbers with ...
Yosuke Fujii, Kiichi Hirota
doaj   +1 more source

The α-mating factor secretion signals and endogenous signal peptides for recombinant protein secretion in Komagataella phaffii

Biotechnology for Biofuels and Bioproducts, 2022
Background The budding yeast Komagataella phaffii (Pichia pastoris) is widely employed to secrete proteins of academic and industrial interest.
Chenwei Zou, Lingfang Lu, Shengyan Wang, Chenshan Zhang, Xuequn Chen, Yao Lin, Yide Huang   +6 more
doaj   +1 more source

HipA-Mediated Phosphorylation of SeqA Does not Affect Replication Initiation in Escherichia coli

Frontiers in Microbiology, 2018
The SeqA protein of Escherichia coli is required to prevent immediate re-initiation of chromosome replication from oriC. The SeqA protein is phosphorylated at the serine-36 (Ser36) residue by the HipA kinase.
Leise Riber, Birgit M. Koch, Line Riis Kruse, Elsa Germain, Anders Løbner-Olesen   +4 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

A low acriflavine dose strongly potentiates the antimicrobial effect of blue light on Staphylococcus aureus

Journal of Photochemistry and Photobiology
Staphylococcus aureus infections are difficult to treat in chronic wounds due to biofilm formation and are frequently compounded by antibiotic resistance, necessitating the development of alternative therapeutic approaches.
Rachel Allen, Yinka Somorin, Matthew Slemon, Eva Zekaite, Conall Haugh, Chloe Hobbs, Merve S. Zeden, James P. O’Gara, Conor O’Byrne   +8 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Advances in Forest Ecophysiology: Stress Response and Ecophysiological Indicators of Tree Vitality

, 2023
Back in the beginning of the year 2021, when the work on this Special Issue started, it was quite clear that the topics of tree stress response and the ecophysiological indicators of tree vitality were both current and important, but the attitude of the ...
Nenad Potočić
core   +1 more source