Proton motive force and antibiotic tolerance in bacteria [PDF]
Microbial BiotechnologyBacterial antibiotic tolerance is a decades‐old phenomenon in which a bacterial sub‐population, commonly known as persisters, does not respond to antibiotics and remains viable upon prolonged antimicrobial treatment.
Yingkun Wan +3 more
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Development of Fluoroquinolone Resistance through Antibiotic Tolerance in Campylobacter jejuni
Microbiology Spectrum, 2022 Antibiotic tolerance not only enables bacteria to survive acute antibiotic exposures but also provides bacteria with a window of time in which to develop antibiotic resistance.
Jinshil Kim +2 more
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Combating Antibiotic Tolerance Through Activating Bacterial Metabolism
Frontiers in Microbiology, 2020 The emergence of antibiotic tolerance enables genetically susceptible bacteria to withstand the killing by clinically relevant antibiotics. As is reported, an increasing body of evidence sheds light on the critical and underappreciated role of antibiotic
Yuan Liu
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Pleiotropic cellular responses underlying antibiotic tolerance in Campylobacter jejuni [PDF]
Frontiers in MicrobiologyAntibiotic tolerance enables antibiotic-susceptible bacteria to withstand prolonged exposure to high concentrations of antibiotics. Although antibiotic tolerance presents a major challenge for public health, its underlying molecular mechanisms remain ...
Eunshin Cho +11 more
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Frontiers in Microbiology, 2021 Recent laboratory evolution studies have shown that upon repetitive antibiotic treatments, bacterial populations will adapt and eventually became tolerant and resistant to the drug.
Jordy Evan Sulaiman, Henry Lam
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Mechanisms of Antibiotic Tolerance in Mycobacterium avium Complex: Lessons From Related Mycobacteria
Frontiers in Microbiology, 2020 Mycobacterium avium complex (MAC) species are the most commonly isolated nontuberculous mycobacteria to cause pulmonary infections worldwide. The lengthy and complicated therapy required to cure lung disease due to MAC is at least in part due to the ...
Harley Parker +2 more
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A Study of Antibiotic Tolerance to Levofloxacin and Rifampin in Staphylococcus aureus Isolates Causing Prosthetic Joint Infections: Clinical Relevance and Treatment Challenges [PDF]
AntibioticsBackground: Antibiotic tolerance in Staphylococcus aureus biofilms poses a major clinical challenge in prosthetic joint infections (PJIs). This study aimed to characterize the antibiotic tolerance of clinical S.
María Ángeles Meléndez-Carmona +3 more
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Restriction of arginine induces antibiotic tolerance in Staphylococcus aureus [PDF]
Nature CommunicationsStaphylococcus aureus is responsible for a substantial number of invasive infections globally each year. These infections are problematic because they are frequently recalcitrant to antibiotic treatment.
Jeffrey A. Freiberg +7 more
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Flagellar motility and the mucus environment influence aggregation-mediated antibiotic tolerance of Pseudomonas aeruginosa in chronic lung infection [PDF]
mBioPseudomonas aeruginosa routinely causes chronic lung infection in individuals with muco-obstructive airway diseases (MADs). In MADs, P. aeruginosa forms antibiotic-tolerant biofilm-like aggregates within hyperconcentrated airway mucus.
Matthew G. Higgs +6 more
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Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of Klebsiella pneumoniae. [PDF]
PLoS PathogensAntibiotic tolerance is the ability of bacteria to survive normally lethal doses of antibiotics for extended time periods. Clinically significant Enterobacterales, for example, can exhibit high tolerance to the last-resort antibiotic meropenem. Meropenem
Trevor Cross +9 more
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