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Proton motive force and antibiotic tolerance in bacteria [PDF]
Microbial BiotechnologyBacterial antibiotic tolerance is a decades‐old phenomenon in which a bacterial sub‐population, commonly known as persisters, does not respond to antibiotics and remains viable upon prolonged antimicrobial treatment.
Yingkun Wan +3 more
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Restriction of arginine induces antibiotic tolerance in Staphylococcus aureus [PDF]
Nature CommunicationsStaphylococcus aureus is responsible for a substantial number of invasive infections globally each year. These infections are problematic because they are frequently recalcitrant to antibiotic treatment.
Jeffrey A. Freiberg +7 more
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Development of Fluoroquinolone Resistance through Antibiotic Tolerance in Campylobacter jejuni
Microbiology Spectrum, 2022 Antibiotic tolerance not only enables bacteria to survive acute antibiotic exposures but also provides bacteria with a window of time in which to develop antibiotic resistance.
Myungseo Park +5 more
doaj +4 more sources
Antibiotic tolerance among clinical isolates: mechanisms, detection, prevalence, and significance [PDF]
Clinical Microbiology ReviewsSUMMARY Antibiotic treatment failures in the absence of resistance are not uncommon. Recently, attention has grown around the phenomenon of antibiotic tolerance, an underappreciated contributor to recalcitrant infections first detected in the 1970s ...
Joanne K Hobbs
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Frontiers in Microbiology, 2023 The bacterium Pseudomonas aeruginosa is involved in chronic infections of cystic fibrosis lungs and chronic wounds. In these infections the bacteria are present as aggregates suspended in host secretions.
Ziwei Liang +8 more
doaj +2 more sources
International Journal of Molecular Sciences, 2023 Antibiotic tolerance has become an increasingly serious crisis that has seriously threatened global public health. However, little is known about the exogenous factors that can trigger the development of antibiotic tolerance, both in vivo and in vitro ...
Inam Muhammad +2 more
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Antibiotic tolerance: targeting bacterial survival.
Current Opinion in Microbiology, 2023 Antimicrobial susceptibility testing is the cornerstone of antibiotic treatments. Yet, active drugs are frequently unsuccessful in vivo and most clinical trials investigating antibiotics fail.
L. Boeck
semanticscholar +3 more sources
Antibiotic tolerance and persistence have distinct fitness trade-offs.
PLoS Pathogens, 2022 Genetically susceptible bacteria can escape the action of bactericidal antibiotics through antibiotic tolerance or persistence. However, one major difference between the two phenomena is their distinct penetrance within an isogenic population. While with
Charlotte Michaux +3 more
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Microbiology Spectrum, 2023 Carbohydrate metabolism plays essential roles in energy generation and providing carbon skeletons for amino acid syntheses. In addition, carbohydrate metabolism has been shown to influence bacterial susceptibility to antibiotics and virulence.
Hao Chen +8 more
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Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms
Cell Host and Microbe, 2019 Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, in medicine, and in industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial
Jing Yan, Bonnie L Bassler
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