Results 11 to 20 of about 1,969,887 (183)

Combating Antibiotic Tolerance Through Activating Bacterial Metabolism

Frontiers in Microbiology, 2020
The emergence of antibiotic tolerance enables genetically susceptible bacteria to withstand the killing by clinically relevant antibiotics. As is reported, an increasing body of evidence sheds light on the critical and underappreciated role of antibiotic
Yuan Liu, Yuan Liu, Yuan Liu, Yuan Liu, Kangni Yang, Haijie Zhang, Yuqian Jia, Zhiqiang Wang, Zhiqiang Wang, Zhiqiang Wang   +9 more
doaj   +3 more sources

Pleiotropic cellular responses underlying antibiotic tolerance in Campylobacter jejuni [PDF]

Frontiers in Microbiology
Antibiotic tolerance enables antibiotic-susceptible bacteria to withstand prolonged exposure to high concentrations of antibiotics. Although antibiotic tolerance presents a major challenge for public health, its underlying molecular mechanisms remain ...
Eunshin Cho, Eunshin Cho, Jinshil Kim, Jinshil Kim, Jinshil Kim, Jinshil Kim, Jeong In Hur, Jeong In Hur, Sangryeol Ryu, Sangryeol Ryu, Sangryeol Ryu, Byeonghwa Jeon   +11 more
doaj   +2 more sources

Evolution of Bacterial Tolerance Under Antibiotic Treatment and Its Implications on the Development of Resistance

Frontiers in Microbiology, 2021
Recent laboratory evolution studies have shown that upon repetitive antibiotic treatments, bacterial populations will adapt and eventually became tolerant and resistant to the drug.
Jordy Evan Sulaiman, Henry Lam
doaj   +3 more sources

Mechanisms of Antibiotic Tolerance in Mycobacterium avium Complex: Lessons From Related Mycobacteria

Frontiers in Microbiology, 2020
Mycobacterium avium complex (MAC) species are the most commonly isolated nontuberculous mycobacteria to cause pulmonary infections worldwide. The lengthy and complicated therapy required to cure lung disease due to MAC is at least in part due to the ...
Harley Parker, Rachel Lorenc, Jennie Ruelas Castillo, Petros C. Karakousis, Petros C. Karakousis   +4 more
doaj   +3 more sources

Heterogeneous Flagellar Expression in Single Salmonella Cells Promotes Diversity in Antibiotic Tolerance

mBio, 2021
Antibiotic resistance and tolerance pose a severe threat to human health. How bacterial pathogens acquire antibiotic tolerance is not clear.
Zhihui Lyu, Angela Yang, Patricia Villanueva, Abhyudai Singh, Jiqiang Ling   +4 more
doaj   +2 more sources

Antibiotic tolerance facilitates the evolution of resistance

Science, 2017
Resistance on a background of tolerance Bacteria survive antibiotic exposure either because they are quiescent when antibiotics are around in the highest concentrations (i.e., tolerance) or because they acquire active biochemical resistance mechanisms (i.
Irit Levin-Reisman, Irine Ronin, Orit Gefen, Ilan Braniss, N. Shoresh, N. Balaban   +5 more
semanticscholar   +3 more sources

A Study of Antibiotic Tolerance to Levofloxacin and Rifampin in Staphylococcus aureus Isolates Causing Prosthetic Joint Infections: Clinical Relevance and Treatment Challenges [PDF]

Antibiotics
Background: Antibiotic tolerance in Staphylococcus aureus biofilms poses a major clinical challenge in prosthetic joint infections (PJIs). This study aimed to characterize the antibiotic tolerance of clinical S.
María Ángeles Meléndez-Carmona, Irene Muñoz-Gallego, Mikel Mancheño-Losa, Jaime Lora-Tamayo   +3 more
doaj   +2 more sources

Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of Klebsiella pneumoniae. [PDF]

PLoS Pathogens
Antibiotic tolerance is the ability of bacteria to survive normally lethal doses of antibiotics for extended time periods. Clinically significant Enterobacterales, for example, can exhibit high tolerance to the last-resort antibiotic meropenem. Meropenem
Trevor Cross, Facundo Torres, Nadia Nikulin, Abigail P McGee, Leena Jalees, Rhea Balakrishnan, Tolani Aliyu, Lars F Westblade, Abhyudai Singh, Tobias Dörr   +9 more
doaj   +2 more sources

Flagellar motility and the mucus environment influence aggregation-mediated antibiotic tolerance of Pseudomonas aeruginosa in chronic lung infection [PDF]

mBio
Pseudomonas aeruginosa routinely causes chronic lung infection in individuals with muco-obstructive airway diseases (MADs). In MADs, P. aeruginosa forms antibiotic-tolerant biofilm-like aggregates within hyperconcentrated airway mucus.
Matthew G. Higgs, Matthew A. Greenwald, Cristian Roca, Jade K. Macdonald, Ashelyn E. Sidders, Brian P. Conlon, Matthew C. Wolfgang   +6 more
doaj   +2 more sources

Antibiotic Tolerance and Combination Therapy

mBio, 2015
The recent paper by Haaber et al. (1) highlights another mechanism by which bacterial pathogens may evade the effects of antibiotics. The combination of colistin with vancomycin against Staphylococcus aureus may be antagonistic and may lessen the effectiveness of glycopeptide antibiotic. Colistin, it seems, induces gene expression in S.
David C. Bean, Sarah M. Wigmore
doaj   +3 more sources