Results 11 to 20 of about 909,509 (159)

Antibiotic resistance gene abundances correlate with metal and geochemical conditions in Scottish soils [PDF]

, 2011
The vast majority of antibiotic resistant genes (ARG) acquired by human pathogens have originated from the natural environment. Therefore, understanding factors that influence intrinsic levels of ARG in the environment could be epidemiologically ...
Brajesh K Singh, Seánı́n M. Mccluskey, Seánín M. McCluskey, Colin D Campbell, David W. Graham, Charles W. Knapp, Hudson, Gordon, Charles W Knapp, Gordon Hudson, David W Graham, Seánín M McCluskey, McCluskey, Seánín M., Campbell, Colin D., Graham, David W., Knapp, Charles W., Singh, Brajesh K., Brajesh K. Singh, Colin D. Campbell   +17 more
core   +4 more sources

Activity Based Tolerance Allocation (ABTA) – Driving tolerance synthesis by evaluating its global cost [PDF]

, 2009
This paper deals with tolerance allocation driven by an activity based approach. Its main objective is to rationally give a good indicator of the relevance of tolerances values fixed by designers.
MARTIN, Patrick, SIADAT, Ali, DANTAN, Jean-Yves, ETIENNE, Alain   +3 more
core   +1 more source

The role of microbiology and pharmacy departments in the stewardship of antibiotic prescribing in European hospitals [PDF]

, 2007
This observational, cross-sectional study describes the role played by clinical microbiology and pharmacy departments in the stewardship of antibiotic prescribing in European hospitals.
MacKenzie, F.M., Krcmery, V., Mollison, J., Mollison, Jill, Krcmery, Vladimir, van der Meer, Jos W. M., van der Meer, Jos W.M., Bruce, J., Gould, I., Meer, J.W.M. van der, Gould, I.M., MacKenzie, Fiona M., Monnet, Dominique L., Gould, Ian M., Bruce, Julie, MacKenzie, Fiona, Cookson, Barry, Monnet, D.L., Cookson, B., Bruce, J. (Julie)   +19 more
core   +4 more sources

Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation but not anaerobic respiration [PDF]

, 2014
Non-inherited antibiotic resistance is a phenomenon whereby a subpopulation of genetically identical bacteria displays phenotypic tolerance to antibiotics. We show that, compared to E. coli, the clinically relevant genus Burkholderia displays much higher
Butler, Clive S., Titball, Richard W., Andreae, Clio A., Luo, Jamie X., Soyer, Orkun S., Hemsley, Claudia M.   +5 more
core   +1 more source

Targeting Antibiotic Tolerance, Pathogen by Pathogen

, 2020
Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays a critical and underappreciated role in the disease burden of bacterial infections.
Andrews, Ian W., Meylan, Sylvain, Collins, James J.   +2 more
core   +2 more sources

Nanoparticles Promote Bacterial Antibiotic Tolerance via Inducing Hyperosmotic Stress Response. [PDF]

, 2022
With the rapid development of nanotechnology, nanoparticles (NPs) are widely used in all fields of life. Nowadays, NPs have shown extraordinary antimicrobial activities and become one of the most popular strategies to combat antibiotic resistance ...
Yun Qiu, Zhang, Yufeng, Zhang, Peng, Leyi Xiao, Peng Zhang, Shimin Yu, Ni, Yueqi, Pu, Yingying, Yulan Wang, Yingying Pu, Xiao, Leyi, Yufeng Zhang, Miron, Richard J, Qiu, Yun, Wang, Yulan, Shi, Miusi, Yu, Shimin, Yueqi Ni, Richard J. Miron, Miusi Shi   +19 more
core   +1 more source

Tolerance analysis approach based on the classification of uncertainty (aleatory / epistemic) [PDF]

, 2012
Uncertainty is ubiquitous in tolerance analysis problem. This paper deals with tolerance analysis formulation, more particularly, with the uncertainty which is necessary to take into account into the foundation of this formulation.
Qureshi, A.J., LEMAIRE, Maurice, Etienne, A., DANTAN, Jean-Yves, Gayton, Nicolas, QURESHI, Ahmed Jawad, GAYTON, N., Lemaire, M., ETIENNE, Alain, Dantan, J.Y.   +9 more
core   +1 more source

Antibiotic Tolerance and Persistence Studied Throughout Bacterial Growth Phases [PDF]

, 2021
Antibiotic tolerance and persistence allow bacteria to survive lethal doses of antibiotic drugs in the absence of genetic resistance. Despite the urgent need to address these phenomena as a cause of clinical antibiotic treatment failure, studies on ...
Cinzia Fino, Fino, Cinzia, Enea Maffei, Harms, Alexander, Alexander Harms, Maffei, Enea   +5 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Human serum triggers antibiotic tolerance in Staphylococcus aureus [PDF]

, 2022
Staphylococcus aureus frequently causes infections that are challenging to treat, leading to high rates of persistent and relapsing infection. Here, to understand how the host environment influences treatment outcomes, we study the impact of human serum ...
Edwards, A.M., Ledger, Elizabeth, Mesnage, Stephane, Edwards, Andrew, Mesnage, S., Ledger, E.V.K.   +5 more
core   +1 more source