Results 21 to 30 of about 1,969,887 (183)
Antibiotic tolerance due to restriction of cAMP-Crp regulation by mannitol, a non-glucose-family PTS carbon source [PDF]
mSphereEnzyme-IIA (EIIAGlc, Crr) of the phosphotransferase system (PTS) connects the uptake of glucose-family sugars to the cAMP-Crp regulatory cascade; phosphorylated EIIAGlc enhances cAMP-Crp activity, which then contributes to the antibiotic-mediated ...
Weiwei Zhu +14 more
doaj +2 more sources
Shooting yourself in the foot: How immune cells induce antibiotic tolerance in microbial pathogens.
PLoS Pathogens, 2021 Antibiotic treatment failure of infection is common and frequently occurs in the absence of genetically encoded antibiotic resistance mechanisms. In such scenarios, the ability of bacteria to enter a phenotypic state that renders them tolerant to the ...
Jenna E Beam +2 more
doaj +2 more sources
Molecular Cell, 2019 Cell dormancy is a widespread mechanism used by bacteria to evade environmental threats, including antibiotics. Here we monitored bacterial antibiotic tolerance and regrowth at the single-cell level and found that each individual survival cell shows ...
Xin Jin, Ziyi Zhao, Zhanghua Chen
exaly +2 more sources
Antibiotics: Combatting Tolerance To Stop Resistance
mBio, 2019 Antibiotic resistance poses an alarming and ever-increasing threat to modern health care. Although the current antibiotic crisis is widely acknowledged, actions taken so far have proved insufficient to slow down the rampant spread of resistant pathogens.
Etthel M. Windels +4 more
doaj +3 more sources
Antibiotic tolerance and persistence in clinical isolates of Escherichia coli evaluated by high-resolution time-kill assays [PDF]
Microbiology SpectrumBacteria showing tolerance to antibiotic killing are characterized by a slower kill rate compared with other isolates from the same species. Antibiotic persistence is defined by a subpopulation of bacteria showing a reduced kill rate when an isolate is ...
N. R. Alexandersen +4 more
doaj +2 more sources
Antibiotic tolerance in pneumococci [PDF]
Clinical Microbiology and Infection, 2002 When bacteria such as Staphylococcus aureus and Streptococcus pneumoniae are exposed to lytic antibiotics such as penicillin and vancomycin, a self-induced killing process is initiated in the organism. This killing occurs via both non-lytic and lytic processes.
Normark, Benriques Henriques +1 more
openaire +2 more sources
Restriction of Arginine Induces Antibiotic Tolerance in Staphylococcus aureus
bioRxiv, 2023 Staphylococcus aureus is responsible for a substantial number of invasive infections globally each year. These infections are problematic because they are frequently recalcitrant to antibiotic treatment, particularly when they are caused by Methicillin ...
Jeffrey A. Freiberg +3 more
semanticscholar +1 more source
Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus
iScience, 2023 Summary Staphylococcus aureus is a leading human pathogen that frequently causes relapsing infections. The failure of antibiotics to eradicate infection contributes to infection relapse.
Jenna E. Beam +6 more
semanticscholar +1 more source
Antibiotics, 2022 Pseudomonas aeruginosa infection is considered a high-risk nosocomial infection and is very difficult to eradicate because of its tolerance to antibiotic treatment.
Muhammad Reza Pahlevi +4 more
doaj +1 more source