Results 41 to 50 of about 1,969,887 (183)

Fitness landscape of antibiotic tolerance in Pseudomonas aeruginosa biofilms. [PDF]

PLoS Pathogens, 2011
Bacteria in biofilms have higher antibiotic tolerance than their planktonic counterparts. A major outstanding question is the degree to which the biofilm-specific cellular state and its constituent genetic determinants contribute to this hyper-tolerant ...
Sasan Amini, Alison K Hottes, Lincoln E Smith, Saeed Tavazoie   +3 more
doaj   +1 more source

Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli

Communications Biology, 2021
Recent evidence suggests that metabolic shutdown alone does not fully explain how bacteria exhibit phenotypic antibiotic tolerance. In an attempt to investigate the range of starvation-induced physiological responses underlying tolerance development, we ...
Miaomiao Wang, E. Chan, Yingkun Wan, M. H. Wong, Sheng Chen   +4 more
semanticscholar   +1 more source

Concentration-dependent activity of antibiotics in natural environments

Frontiers in Microbiology, 2013
Bacterial responses to antibiotics are concentration dependent. At high concentrations, antibiotics exhibit antimicrobial activities on susceptible cells, while subinhibitory concentrations induce diverse biological responses in bacteria. At non-lethal
Steve P Bernier, Michael G Surette
doaj   +1 more source

Antimicrobial Peptides Can Generate Tolerance by Lag and Interfere with Antimicrobial Therapy

Pharmaceutics, 2022
Antimicrobial peptides (AMPs) are widely distributed molecules secreted mostly by cells of the innate immune system to prevent bacterial proliferation at the site of infection.
Daniel Sandín, Javier Valle, Jordi Morata, David Andreu, Marc Torrent   +4 more
doaj   +1 more source

From the soil to the clinic: The impact of microbial secondary metabolites on antibiotic tolerance and resistance

Nature Reviews Microbiology, 2021
Secondary metabolites profoundly affect microbial physiology, metabolism and stress responses. Increasing evidence suggests that these molecules can modulate microbial susceptibility to commonly used antibiotics; however, secondary metabolites are ...
Elena K. Perry, Lucas A. Meirelles, D. Newman   +2 more
semanticscholar   +1 more source

Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics

mBio, 2022
Metabolic and growth arrest are primary drivers of antibiotic tolerance and persistence in clinically diverse bacterial pathogens. We recently showed that adenosine (ADO) suppresses bacterial growth under nutrient-limiting conditions.
David A. Kitzenberg, J. Scott Lee, Krista B. Mills, Ju-Sim Kim, Lin Liu, Andrés Vázquez-Torres, Sean P. Colgan, Daniel J. Kao   +7 more
doaj   +1 more source

Convergent Evolution of Antibiotic Tolerance in Patients with Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia

Infection and Immunity, 2022
Severe infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are often complicated by persistent bacteremia (PB) despite active antibiotic therapy.
M. M. Elgrail, Edwin Chen, Marla G. Shaffer, V. Srinivasa, M. Griffith, M. Mustapha, R. K. Shields, D. Van Tyne, M. Culyba   +8 more
semanticscholar   +1 more source

Membrane Transporters of the Major Facilitator Superfamily Are Essential for Long-Term Maintenance of Phenotypic Tolerance to Multiple Antibiotics in E. coli

Microbiology Spectrum, 2021
Antibiotic tolerance is not only the key underlying the cause of recurrent and chronic bacterial infections but it is also a factor linked to exacerbation of diseases, such as tuberculosis, cystic fibrosis-associated lung infection, and candidiasis. This
Yingkun Wan, Miaomiao Wang, Edward Wai Chi Chan, Sheng Chen   +3 more
doaj   +1 more source

Anthranilate Acts as a Signal to Modulate Biofilm Formation, Virulence, and Antibiotic Tolerance of Pseudomonas aeruginosa and Surrounding Bacteria

Microbiology spectrum, 2022
Pseudomonas aeruginosa is a notorious pathogen with high antibiotic resistance, strong virulence, and ability to cause biofilm-mediated chronic infection.
Hyeon-Ji Hwang, Xi-Hui Li, Soo-Kyoung Kim, Joon-Hee Lee   +3 more
semanticscholar   +1 more source

Quaternary ammonium disinfectants and antiseptics: tolerance, resistance and potential impact on antibiotic resistance

Antimicrobial Resistance and Infection Control, 2023
Background Due to the substantial increase in the use of disinfectants containing quaternary ammonion compounds (QACs) in healthcare and community settings during the COVID-19 pandemic, there is increased concern that heavy use might cause bacteria to ...
John M. Boyce
doaj   +1 more source