Results 61 to 70 of about 188,321 (291)

The Varied Role of Efflux Pumps of the MFS Family in the Interplay of Bacteria with Animal and Plant Cells [PDF]

, 2019
Efflux pumps represent an important and large group of transporter proteins found in all organisms. The importance of efflux pumps resides in their ability to extrude a wide range of antibiotics, resulting in the emergence of multidrug resistance in many
Barras, Frederic, Colonna, Bianca, Fanelli, Giulia, Grossi, Milena, Micheli, Gioacchino, Pasqua, Martina, Prosseda, Gianni, Zennaro, Alessandro   +7 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Persisters show heritable phenotype and generate bacterial heterogeneity and noise in protein expression [PDF]

, 2009
Persisters are a small subpopulation of bacteria that survive a lethal concentration of antibiotic without antibiotic resistance genes. Isolation of persisters from normally dividing population is considered difficult due to their slow growth, low ...
Jaison Jacob
core   +1 more source

Collective antibiotic tolerance: mechanisms, dynamics and intervention [PDF]

Nature Chemical Biology, 2015
Bacteria have developed resistance against every antibiotic at a rate that is alarming considering the timescale at which new antibiotics are developed. Thus, there is a critical need to use antibiotics more effectively, extend the shelf life of existing antibiotics and minimize their side effects.
Hannah R, Meredith, Jaydeep K, Srimani, Anna J, Lee, Allison J, Lopatkin, Lingchong, You   +4 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Adaptation and Antibiotic Tolerance of Anaerobic Burkholderia pseudomallei [PDF]

Antimicrobial Agents and Chemotherapy, 2011
ABSTRACT The Gram-negative bacterium Burkholderia pseudomallei is the etiological agent of melioidosis and is remarkably resistant to most classes of antibacterials. Even after months of treatment with antibacterials that are relatively effective in vitro
Mohamad A, Hamad, Chad R, Austin, Amanda L, Stewart, Mike, Higgins, Andrés, Vázquez-Torres, Martin I, Voskuil   +5 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Mucus polymer concentration and in vivo adaptation converge to define the antibiotic response of Pseudomonas aeruginosa during chronic lung infection

mBio
The airway milieu of individuals with muco-obstructive airway diseases (MADs) is defined by the accumulation of dehydrated mucus due to hyperabsorption of airway surface liquid and defective mucociliary clearance. Pathological mucus becomes progressively
Matthew A. Greenwald, Suzanne L. Meinig, Lucas M. Plott, Cristian Roca, Matthew G. Higgs, Nicholas P. Vitko, Matthew R. Markovetz, Kaitlyn R. Rouillard, Jerome Carpenter, Mehmet Kesimer, David B. Hill, Jonathan C. Schisler, Matthew C. Wolfgang   +12 more
doaj   +1 more source

The role of small proteins in Burkholderia cenocepacia J2315 biofilm formation, persistence and intracellular growth [PDF]

, 2019
Burkholderia cenocepacia infections are difficult to treat due to resistance, biofilm formation and persistence. B. cenocepacia strain J2315 has a large multi-replicon genome (8.06 Mb) and the function of a large fraction of (conserved) hypothetical ...
Braeckmans, Kevin, Coenye, Tom, Crabbé, Aurélie, Daled, Simon, De Keersmaecker, Herlinde, Deforce, Dieter, Dhaenens, Maarten, Jurėnas, Dukas, Ostyn, Lisa, Sass, Andrea, Teirlinck, Eline, Van Acker, Heleen, Van Melderen, Laurence   +12 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source