Results 51 to 60 of about 909,509 (159)
Persisters show heritable phenotype and generate bacterial heterogeneity and noise in protein expression [PDF]
, 2007 Persisters are a small subpopulation of bacteria that survive a lethal concentration of antibiotic without antibiotic resistance genes. Isolation of persisters from normally dividing population is considered difficult due to their slow growth, low ...
Jaison Jacob
core
Autonomous Navigation of Pollen‐Inspired Magnetic Microrobots for Biomedical Applications
Advanced Robotics Research, EarlyView.A sunflower pollen‐inspired magnetic microrobot enables controlled rolling navigation in vessel‐like environments. Its open geometry reduces hydrodynamic drag, while vision‐based closed‐loop control, shortest‐path planning, and reinforcement learning support target‐reaching and maze navigation with microrobot‐scale accuracy, highlighting a route toward
Ali Anil Demircali +6 more
wiley +1 more source
A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for staphylococcal infections. [PDF]
, 2010 In a clinical infection, multiplying and non-multiplying bacteria co-exist. Antibiotics kill multiplying bacteria, but they are very inefficient at killing non-multipliers which leads to slow or partial death of the total target population of microbes in
Liu, Y +11 more
core +2 more sources
Advanced Science, EarlyView.Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen +19 more
wiley +1 more source
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source
Antibiotic resistance: how did we get here and what can we do? [PDF]
, 2013 Executive summary Does antibiotic resistance exist? Yes. It is a worsening phenomenon seen all over the world, including Australia. What are the implications of antibiotic resistance?
Sanjaya Senanayake
core
Advanced Science, EarlyView.Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He +10 more
wiley +1 more source
, 2019 Renata Galetti,1 Rafael Antonio Casarin Penha Filho,2 Joseane Cristina Ferreira,1 Alessandro M Varani,2 Ana Lúcia Costa Darini11Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeir ...
Penha Filho RAC +4 more
core
Advanced Science, EarlyView.Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao +9 more
wiley +1 more source