Results 51 to 60 of about 1,969,887 (183)
The ISME Journal, 2021 Pseudomonas aeruginosa biofilms exhibit an intrinsic resistance to antibiotics and constitute a considerable clinical threat. In cystic fibrosis, a common feature of biofilms formed by P. aeruginosa in the airway is the occurrence of mutants deficient in
Jules D. P. Valentin +8 more
semanticscholar +1 more source
BMC Microbiology, 2010 Background Biofilms are ubiquitous. For instance, the majority of medical infections are thought to involve biofilms. However even after decades of investigation, the in vivo efficacy of many antimicrobial strategies is still debated suggesting there is ...
Jimenez-Taracido Lourdes +5 more
doaj +1 more source
Proteolytic Queues at ClpXP Increase Antibiotic Tolerance [PDF]
ACS Synthetic Biology, 2019 Abstract Antibiotic tolerance is a widespread phenomenon that renders antibiotic treatments less effective and facilitates antibiotic resistance. Here we explore the role of proteases in antibiotic tolerance, short-term population survival of antibiotics, using queueing theory (i.e.
Heather S. Deter +5 more
openaire +2 more sources
Human serum triggers antibiotic tolerance in Staphylococcus aureus
Nature Communications, 2021 Staphylococcus aureus frequently causes infections that are challenging to treat, leading to high rates of persistent and relapsing infection. Here, to understand how the host environment influences treatment outcomes, we study the impact of human serum ...
E. Ledger, S. Mesnage, A. Edwards
semanticscholar +1 more source
Microbiology spectrum, 2022 Chronic MRSA infections remain challenging to treat in patients with cystic fibrosis (CF). The ability of the bacterial population to survive high concentrations of bactericidal antibiotics, including vancomycin, despite lacking resistance is considered ...
Kuan‐Yi Lu +5 more
semanticscholar +1 more source
Does diagnostic uncertainty increase antibiotic prescribing in primary care?
npj Primary Care Respiratory Medicine, 2021 This study aimed to determine the association between factors relevant to diagnostic uncertainty and physicians’ antibiotic-prescribing behaviour in primary care.
Dan Wang +3 more
doaj +1 more source
iScience, 2021 Summary: Recent discoveries indicate that tolerance and resistance could rapidly evolve in bacterial populations under intermittent antibiotic treatment. In the present study, we applied antibiotic combinations in laboratory experiments to generate novel
Jordy Evan Sulaiman +4 more
doaj +1 more source
PurN Is Involved in Antibiotic Tolerance and Virulence in Staphylococcus aureus
Antibiotics, 2022 Staphylococcus aureus can cause chronic infections which are closely related to persister formation. Purine metabolism is involved in S. aureus persister formation, and purN, encoding phosphoribosylglycinamide formyltransferase, is an important gene in ...
Qiuying Peng +7 more
semanticscholar +1 more source
Antioxidants, 2022 Compositions and activities of bacterial flora in the gastrointestinal tract significantly influence the metabolism, health, and disease of host humans and animals.
Rajalakshmi Balasubramanian +7 more
semanticscholar +1 more source
Genetic Determinants of Intrinsic Antibiotic Tolerance in Mycobacterium avium
Microbiology Spectrum, 2021 The Mycobacterium avium complex (MAC) is one of the most prevalent causes of nontuberculous mycobacteria pulmonary infection in the United States, and yet it remains understudied.
William M. Matern +5 more
doaj +1 more source