Results 71 to 80 of about 1,969,887 (183)

Mucus polymer concentration and in vivo adaptation converge to define the antibiotic response of Pseudomonas aeruginosa during chronic lung infection

mBio
The airway milieu of individuals with muco-obstructive airway diseases (MADs) is defined by the accumulation of dehydrated mucus due to hyperabsorption of airway surface liquid and defective mucociliary clearance. Pathological mucus becomes progressively
Matthew A. Greenwald, Suzanne L. Meinig, Lucas M. Plott, Cristian Roca, Matthew G. Higgs, Nicholas P. Vitko, Matthew R. Markovetz, Kaitlyn R. Rouillard, Jerome Carpenter, Mehmet Kesimer, David B. Hill, Jonathan C. Schisler, Matthew C. Wolfgang   +12 more
doaj   +1 more source

Molecular analysis of antibiotic tolerance in pneumococci

International Journal of Medical Microbiology, 2002
Widespread pneumococcal resistance and the emergence of tolerance underscores the need to develop new antimicrobials. Uncovering the mechanisms of autolysin activation could yield not only new antibacterial targets but also ways to eradicate a pool of bacteria facilitating the spread of resistance.
Lauren S, Mitchell, Elaine I, Tuomanen
openaire   +2 more sources

The Staphylococcus aureus toxin–antitoxin system YefM–YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation

Journal of Bone and Joint Infection, 2021
The high antibiotic tolerance of Staphylococcus aureus biofilms is associated with challenges for treating periprosthetic joint infection. The toxin–antitoxin system, YefM–YoeB, is thought to be a regulator for antibiotic tolerance, but its physiological
Xinyu Qi, Kimberly M. Brothers, Dongzhu Ma, Jonathan B Mandell, N. Donegan, A. Cheung, A. Richardson, K. Urish   +7 more
semanticscholar   +1 more source

Hydrogen Sulfide Sensitizes Acinetobacter baumannii to Killing by Antibiotics

Frontiers in Microbiology, 2020
The production of endogenous hydrogen sulfide (H2S) has been shown to confer antibiotic tolerance in all bacteria studied to date. Therefore, this mediator has been speculated to be a universal defense mechanism against antibiotics in bacteria.
Say Yong Ng, Kai Xun Ong, Smitha Thamarath Surendran, Smitha Thamarath Surendran, Ameya Sinha, Ameya Sinha, Ameya Sinha, Joey Jia Hui Lai, Jacqueline Chen, Jiaqi Liang, Jiaqi Liang, Leona Kwan Sing Tay, Liang Cui, Hooi Linn Loo, Peiying Ho, Jongyoon Han, Jongyoon Han, Jongyoon Han, Wilfried Moreira   +18 more
doaj   +1 more source

Staphylococcus aureus Persisters Tolerant to Bactericidal Antibiotics [PDF]

Microbial Physiology, 2012
Bacterial persister cells are non- or slow-growing reversible phenotypic variants of the wild type, tolerant to bactericidal antibiotics. We analyzed here Staphylococcus aureus persister levels by monitoring colony-forming unit counts of planktonically grown cells treated with six different antimicrobials over time.
Sabrina, Lechner, Kim, Lewis, Ralph, Bertram   +2 more
openaire   +3 more sources

RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy, 2021
Mycobacterium abscessus is an opportunistic pathogen notorious for its resistance to most classes of antibiotics and low cure rates. M. abscessus carries an array of mostly unexplored defense mechanisms.
J. Schildkraut, Jordy P. M. Coolen, Sophie Burbaud, Jasper J. N. Sangen, Michael Kwint, R. Floto, H. O. D. op den Camp, L. T. Te Brake, H. Wertheim, K. Neveling, W. Hoefsloot, J. van Ingen   +11 more
semanticscholar   +1 more source

Global response to antibiotic exposure reveals a critical role for nucleotide metabolism in high-level β-lactam tolerance

npj Antimicrobials and Resistance
Antibiotic tolerance, the ability to survive lethal antibiotics for a prolonged period of time is a rising threat due to its role as a steppingstone towards antibiotic resistance. While tolerance has been recognized as a severe clinical threat, little is
Megan Renee Keller, Misha Iqbal Kazi, Anas Saleh, Upasana Basu, Jung-Ho Shin, Kyu Rhee, Tobias Dörr   +6 more
doaj   +1 more source

Erythromycin treatment hinders the induction of oral tolerance to fed ovalbumin

Frontiers in Immunology, 2012
The mucosal immune system is constantly exposed to antigen, whether it be food antigen, commensal bacteria, or harmful antigen. It is essential that the mucosal immune system can distinguish between harmful and non-harmful antigens, and initiate an ...
Sydney E. Lambert, Jeremy M. Kinder, Jenny E. Then, Kelly N. Parliament, Heather A. Bruns   +4 more
doaj   +1 more source

Antibiotic tolerance among clinical isolates of bacteria [PDF]

Antimicrobial Agents and Chemotherapy, 1986
One of the unique features of p-lactam antibiotics and other cell-wall inhibitors like vancomycin and bacitracin is that they can rapidly kill and in many cases lyse susceptible bacteria. Many other types of antibacterial agents (e.g., trimethoprim or chloramphenicol) are primarily bacteriostatic: they inhibit multiplication but do not cause an ...
E, Tuomanen, D T, Durack, A, Tomasz
openaire   +2 more sources

Expression patterns of core metabolic genes and elevated intracellular ROS confer drug tolerance in Staphylococcus aureus

Microbiology Spectrum
Staphylococcus aureus exhibits remarkable tolerance to antibiotic stress, facilitated by a complex network of cellular responses and metabolism controlled by numerous gene expression patterns that can be rapidly remodeled.
Jiahao Liu, Yeming Li, Haodong Liu, Shunhua Yan, Haoyi Jia, Yuxuan Yang, Wenting Hu, Jingjia Wang, Wenfeng Li, Huping Xue, Xin Zhao, Long Li, Pilong Liu   +12 more
doaj   +1 more source