Results 91 to 100 of about 1,969,887 (183)

Multisite phosphorylation drives phenotypic variation in (p)ppGpp synthetase-dependent antibiotic tolerance

Nature Communications, 2019
Individual bacteria within isogenic populations can differ in antibiotic tolerance. Here, Libby et al. show that antibiotic tolerance variability can be driven by ‘noisy’ expression of a gene encoding a (p)ppGpp synthetase, which is in turn regulated by ...
Elizabeth A. Libby, Shlomi Reuveni, Jonathan Dworkin   +2 more
doaj   +1 more source

Understanding tolerance to cell wall–active antibiotics

Annals of the New York Academy of Sciences, 2020
AbstractAntibiotic tolerance—the ability of bacteria to survive for an extended time in the presence of bactericidal antibiotics—is an understudied contributor to antibiotic treatment failure. Herein, I review the manifestations, mechanisms, and clinical relevance of tolerance to cell wall–active (CWA) antibiotics, one of the most important groups of ...
openaire   +2 more sources

Antibiotic tolerance leads to antibiotic resistance [PDF]

Nature Medicine, 2020
openaire   +2 more sources

Transcriptomic profiling of ceftriaxone-tolerant phenotypes of Neisseria gonorrhoeae reveals downregulation of ribosomal genes — a pilot study

Microbiology Spectrum
Antibiotic tolerance is associated with failure of antibiotic treatment and accelerates the development of antimicrobial resistance. The molecular mechanisms underlying antimicrobial tolerance remain poorly understood.
Sheeba Santhini Manoharan-Basil, Margaux Balduck, Zina Gestels, Said Abdellati, Tessa De Block, Chris Kenyon   +5 more
doaj   +1 more source

Biochemical characteristics of inhaled antibiotics related to tolerability

Farmacia Hospitalaria
Inhaled antibiotics are used in the treatment of various respiratory diseases, including cystic fibrosis (CF), non-CF bronchiectasis, and ventilator-associated pneumonia. While some of these drugs are marketed as ready-to-use formulations, others require prior manipulation, such as dilution or reconstitution procedures that are often not standardized ...
Manuel, Vélez-Díaz-Pallarés, María Ángeles, Parro-Martín, Hilario, Martínez-Barros, Beatriz, Montero-Llorente, Miriam, Menacho-Román, Ana, Gómez-Lozano, Rosa, Nieto Royo, Luis, Máiz Carro, Ana, Álvarez-Díaz   +8 more
openaire   +3 more sources

Graphitic Carbon Nitride Confers Bacterial Tolerance to Antibiotics in Wastewater Relating to ATP Depletion

Molecules
Graphitic carbon nitride (C3N4) is a kind of visible light-responsive photocatalyst that has been of great interest in wastewater treatment. However, its environmental impact and biological effect remains to be elucidated.
Shuo Liu, Lin Teng, Jiantao Ping
doaj   +1 more source

Assessment of Antibiotic Sensitivity in Biofilms Using GelMA Hydrogel Microspheres

Gels
Conventional antibiotic susceptibility testing (AST) primarily assesses planktonic bacteria. However, the three-dimensional architecture and barrier properties of biofilms mean that the minimum inhibitory concentration (MIC) for planktonic cells is ...
Junchi Zhu, Wenqi Chen, Zhenzhi Shi, Yiming Liu, Lulu Shi, Jiafei Xi   +5 more
doaj   +1 more source

Ribosome Hibernation: Tolerance to Antibiotics [PDF]

British Biomedical Bulletin, 2018
Prasad Manderwad, Guru, Hrv, Rajkumar
openaire   +2 more sources

Efficacy and Tolerability of Antibiotic Combinations in

, 2012
No data on whether brucellar meningitis or meningoencephalitis can be treated with oral antibiotics or whether an intravenous extended-spectrum cephalosporin, namely, ceftriaxone, which does not accumulate in phagocytes, should be added to the regimen exist in the literature. The aim of a study conducted in Istanbul, Turkey, was to compare the efficacy
Erdem, H, Ulu-Kilic, A, Kilic, S, Karahocagil, M, Shehata, G, Eren-Tulek, N, Yetkin, F, Celen, MK, Ceran, N, Gul, HC, Mert, G, Tekin-Koruk, S, Dizbay, M, Inal, AS, Nayman-Alpat, S, Bosilkovski, M, Inan, D, Saltoglu, N, Abdel-Baky, L, Adeva-Bartolome, MT, Ceylan, B, Sacar, S, Turhan, V, Yilmaz, E, Elaldi, N, Kocak-Tufan, Z, Ugurlu, K, Dokuzoguz, B, Yilmaz, H, Gundes, S, Guner, R, Ozgunes, N, Ulcay, A, Unal, S, Dayan, S, Gorenek, L, Karakas, A, Tasova, Y, Usluer, G, Bayindir, Y, Kurtaran, B, Sipahi, OR, Leblebicioglu, H   +42 more
openaire   +1 more source

Metabolic perturbation reduces antibiotic tolerance in <i>Mycobacterium tuberculosis</i>. [PDF]

Microbiology (Reading)
Cheung CY, Samuels I, Klaus HR, Cook GM, McNeil MB.   +4 more
europepmc   +1 more source