Results 91 to 100 of about 188,321 (291)

Expression patterns of core metabolic genes and elevated intracellular ROS confer drug tolerance in Staphylococcus aureus

Microbiology Spectrum
Staphylococcus aureus exhibits remarkable tolerance to antibiotic stress, facilitated by a complex network of cellular responses and metabolism controlled by numerous gene expression patterns that can be rapidly remodeled.
Jiahao Liu, Yeming Li, Haodong Liu, Shunhua Yan, Haoyi Jia, Yuxuan Yang, Wenting Hu, Jingjia Wang, Wenfeng Li, Huping Xue, Xin Zhao, Long Li, Pilong Liu   +12 more
doaj   +1 more source

Predicting Antibiotic-Associated Virulence of Pseudomonas aeruginosa Using an ex vivo Lung Biofilm Model

Frontiers in Microbiology, 2020
BackgroundBacterial biofilms are known to have high antibiotic tolerance which directly affects clearance of bacterial infections in people with cystic fibrosis (CF).
Marwa M. Hassan, Marwa M. Hassan, Niamh E. Harrington, Esther Sweeney, Freya Harrison   +4 more
doaj   +1 more source

Burial and seed survival in Brassica napus subsp. oleifera and Sinapis arvensis including a comparison of transgenic and non-transgenic lines of the crop [PDF]

, 1997
The creation of transgenic plants through genetic engineering has focused interest on how the fitness of a plant species may be altered by small changes in its genome. This study concentrates on a key component of fitness: persistence of seeds overwinter.
Crawley, M.J., Hails, R.S., Kohn, D.D., Rees, M.   +3 more
core   +1 more source

Antibiotic tolerance among clinical isolates of bacteria [PDF]

Antimicrobial Agents and Chemotherapy, 1986
One of the unique features of p-lactam antibiotics and other cell-wall inhibitors like vancomycin and bacitracin is that they can rapidly kill and in many cases lyse susceptible bacteria. Many other types of antibacterial agents (e.g., trimethoprim or chloramphenicol) are primarily bacteriostatic: they inhibit multiplication but do not cause an ...
E, Tuomanen, D T, Durack, A, Tomasz
openaire   +2 more sources

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Bacterial defenses against a natural antibiotic promote collateral resilience to clinical antibiotics.

PLoS Biology, 2021
Bacterial opportunistic human pathogens frequently exhibit intrinsic antibiotic tolerance and resistance, resulting in infections that can be nearly impossible to eradicate.
Lucas A Meirelles, Elena K Perry, Megan Bergkessel, Dianne K Newman   +3 more
doaj   +1 more source

Comparative analysis of Salmonella susceptibility and tolerance to the biocide chlorhexidine identifies a complex cellular defense network [PDF]

, 2014
peer-reviewedChlorhexidine is one of the most widely used biocides in health and agricultural settings as well as in the modern food industry. It is a cationic biocide of the biguanide class. Details of its mechanism of action are largely unknown.
Aine eSheridan, Catherine Maeve Burgess, Jarlath eNally, Jay C. D. Hinton, Jay C. D. Hinton, Jenny eRenaut, Karen ePower, Kjell eSergeant, Kristian eHandler, Orla eCondell, Orla eCondell, Sarah eFinn, Seamus eFanning, Seamus eFanning   +13 more
core   +2 more sources

Genipin‐Crosslinked, Silane‐Anchored 3D Tumor–Stroma Microtissues for High‐Content On‐Chip Drug Testing

Advanced Healthcare Materials, EarlyView.
We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach, Reza Kowsari‐Esfahan, Emilia Reszczyńska, Philippe Nghe, Matthias Nees   +4 more
wiley   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Bacterial interspecies interactions modulate pH-mediated antibiotic tolerance

eLife, 2020
Predicting antibiotic efficacy within microbial communities remains highly challenging. Interspecies interactions can impact antibiotic activity through many mechanisms, including alterations to bacterial physiology.
Andrés Aranda-Díaz, Benjamin Obadia, Ren Dodge, Tani Thomsen, Zachary F Hallberg, Zehra Tüzün Güvener, William B Ludington, Kerwyn Casey Huang   +7 more
doaj   +1 more source