Results 101 to 110 of about 188,321 (291)

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Effect of a glyphosate-containing herbicide on Escherichia coli and Salmonella Ser. Typhimurium in an in vitro rumen simulation system [PDF]

, 2019
Glyphosate (N-(phosphonomethyl)glycine) is the most-used herbicide worldwide. Many studies in the past have shown that residues of the herbicide can be found in many cultivated plants, including those used as livestock feed.
Bote, Katrin, Breves, Gerhard, Pöppe, Judith, Riede, Susanne, Roesler, Uwe   +4 more
core   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Addressing the fears of the natural rubber supply chain regarding the dissemination of genetically modified rubber trees [PDF]

, 2011
The development of genetic engineering in Hevea is designed to speed up the breeding process for traits that are essential to the sustainable production of natural rubber.
Montoro, Pascal
core  

Oxygen Supply of Islets of Langerhans by Photosynthetically Active Microalgae in Bioprinted Co‐Cultures Maintains Their Function in a Hypoxic Environment

Advanced Healthcare Materials, EarlyView.
This study developed a bioprinted co‐culture system embedding rat pancreatic islets and Scenedesmus sp. microalgae spatially defined in close vicinity. Red light was found optimal to ensure microalgal photosynthesis while maintaining islet viability and functionality. A tailored co‐culture medium supported both cell types.
Finn Dani, Sarah Duin, Ashwini Rahul Akkineni, Susann Lehmann, Barbara Ludwig, Michael Kühl, Michael Gelinsky, Anja Lode   +7 more
wiley   +1 more source

Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial [PDF]

, 2018
Funder: UK National Institute for Health Research. Open Access funded by Department of Health UK Acknowledgments We thank all the participants for their commitment to the study, Sheila Wallace for updating the systematic review, members of the Trial ...
Abdel-Fattah, Mohamed, Brennand, Catherine, Chadwick, Thomas, Fader, Mandy, Fisher, Holly, Harrison, Simon, Hilton, Paul, Larcombe, James, Little, Paul, McClurg, Doreen, McColl, Elaine, N’Dow, James, Oluboyede, Yemi, Pickard, Robert, Ternent, Laura, Thiruchelvam, Nikesh, Timoney, Anthony, Vale, Luke, von Wilamowitz-Moellendorff, Alexander, Walton, Katherine, Wilkinson, Jennifer, Wood, Ruth   +21 more
core   +2 more sources

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an in Vivo Murine Burn Model Study

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source

Autolysis Control Hypotheses for Tolerance to Wall Antibiotics [PDF]

Antimicrobial Agents and Chemotherapy, 2001
Antibiotics are divided into two classes: bacteriostatic and bactericidal. The reasons for their classification are usually self-evident, although seldom proven. For example, chloramphenicol stops protein synthesis and is bacteriostatic, probably because when it is removed growth can recommence.
openaire   +2 more sources

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source