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Antibiotic resistance in the environment [PDF]
Nature Reviews Microbiology, 2021 Antibiotic resistance is a global health challenge, involving the transfer of bacteria and genes between humans, animals and the environment. Although multiple barriers restrict the flow of both bacteria and genes, pathogens recurrently acquire new resistance factors from other species, thereby reducing our ability to prevent and treat bacterial ...
D G Joakim Larsson +2 more
exaly +3 more sources
Targeting Antibiotic Resistance
Angewandte Chemie - International Edition, 2016 AbstractFinding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human‐pathogenic bacteria that are resistant to one or multiple antibiotics.
Mathieu F Chellat +2 more
exaly +4 more sources
Critical Care Clinics, 1998 Antibiotic resistance is an increasing problem in many parts of the world. Antibiotic resistance has been associated with the use of some antibiotics but not with others. Due to the overuse of antibiotics with a high resistance potential, there has been an increase of resistance with certain bacteria, e.g., Staphylococcus aureus, Pseudomonas aeruginosa
A J, Smith, K, Roy, J, Gibson, J, Bagg
+9 more sources
Resistance-resistant antibiotics [PDF]
Trends in Pharmacological Sciences, 2014 New antibiotics are needed because drug resistance is increasing while the introduction of new antibiotics is decreasing. We discuss here six possible approaches to develop 'resistance-resistant' antibiotics. First, multitarget inhibitors in which a single compound inhibits more than one target may be easier to develop than conventional combination ...
Eric, Oldfield, Xinxin, Feng
openaire +2 more sources
Antimicrobial Resistance and Infection Control, 2022 Background The incidence of Escherichia coli bloodstream infections (BSI) is high and increasing. We aimed to describe the effect of season and temperature on the incidence of E. coli BSI and antibiotic-resistant E.
Sarah F. Feldman +8 more
doaj +1 more source
A framework for identifying the recent origins of mobile antibiotic resistance genes
Communications Biology, 2021 Ebmeyer and colleagues developed a genomic framework for identification and scrutiny of the origins of antibiotic resistance genes. Using data scoured from the literature and publicly available genomes, their results indicate that only 81% of previously ...
Stefan Ebmeyer +2 more
doaj +1 more source
Microbiome, 2020 Background New antibiotic resistance determinants are generally discovered too late, long after they have irreversibly emerged in pathogens and spread widely.
Maria-Elisabeth Böhm +4 more
doaj +1 more source
Journal of Infection and Public Health, 2017 Antimicrobial resistance in bacterial pathogens is a challenge that is associated with high morbidity and mortality. Multidrug resistance patterns in Gram-positive and -negative bacteria are difficult to treat and may even be untreatable with conventional antibiotics.
Marianne Frieri +2 more
openaire +5 more sources
A Novel, Integron-Regulated, Class C β-Lactamase
Antibiotics, 2020 AmpC-type β-lactamases severely impair treatment of many bacterial infections, due to their broad spectrum (they hydrolyze virtually all β-lactams, except fourth-generation cephalosporins and carbapenems) and the increasing incidence of plasmid-
Maria-Elisabeth Böhm +3 more
doaj +1 more source
The Association between Insertion Sequences and Antibiotic Resistance Genes
mSphere, 2020 Insertion sequences (ISs) are abundant mobile genetic elements on bacterial genomes, responsible for mobilization of many genes, including antibiotic resistance genes (ARGs).
Mohammad Razavi +3 more
doaj +1 more source