Results 41 to 50 of about 2,829,471 (309)

Antibiotic Resistance

Cell, 2018
Bacterial mechanisms of drug resistance operate at sequential lines of defense tackling drug at entry, accumulation, target binding, or downstream toxicity. These mechanisms are encoded by genomic changes ranging in scale from point mutations, through assembly of preexisting genetic elements, to horizontal import of genes from the environment.
Idan Yelin, Roy Kishony
openaire   +3 more sources

ANTIBIOTIC RESISTANCE

Journal of Research in Pharmacy, 2023
Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance occurs when the response of bacteria to medicines. Unfortunately nowadays the emergence of resistance among bacterial pathogens is a major public worldwide health problem.
openaire   +4 more sources

Unraveling the Diversity of Co-Colonization by CPE

Microorganisms, 2022
Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency
Gabrielle Levi, Mor Lurie-Weinberger, Alona Keren-Paz, Antoine O. Andremont, David Schwartz, Yehuda Carmeli   +5 more
doaj   +1 more source

Vaccines in the fight against antimicrobial resistance – from evidence to policy - perspectives from South Africa

International Journal of Infectious Diseases
Introduction: The rising prevalence of drug-resistant infections presents a challenge to modern medicine by limiting life-saving therapeutic options, especially for those who cannot afford more expensive second-and third-line antibiotics, and ...
Dr Elloise Du Toit, Dr Erta Kalanxhi, Prof Adrian Brink, Ms Isabella Impalli   +3 more
doaj   +1 more source

Managing pollution from antibiotics manufacturing: charting actors, incentives and disincentives

Environmental Health, 2019
Background Emissions of high concentrations of antibiotics from manufacturing sites select for resistant bacteria and may contribute to the emergence of new forms of resistance in pathogens. Many scientists, industry, policy makers and other stakeholders
Niels Nijsingh, Christian Munthe, D. G. Joakim Larsson   +2 more
doaj   +1 more source

Active surveillance for carbapenem-resistant Acinetobacter baumannii (CRAB) carriage

Microbiology Spectrum, 2023
Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a significant threat in healthcare settings, necessitating robust infection control measures. To identify the most effective sampling method for CRAB carriage detection, we conducted a comparative
Amir Nutman, Gabrielle D. Levi, Alona Keren-Paz, David Schwartz, Samira Masarwa, Vered Schechner, Yehuda Carmeli   +6 more
doaj   +1 more source

New antibiotics for antibiotic-resistant bacteria [PDF]

F1000 Biology Reports, 2009
The need for new antibiotics to effectively treat antibiotic-resistant infections remains unfulfilled. Despite the well-publicised concern over this issue, only two novel antibiotic classes have been introduced in the past 20 years alongside several new agents of existing classes.
Stubbings, William, Labischinski, Harald
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source