Results 51 to 60 of about 545,691 (312)

In vivo Fitness of Acinetobacter baumannii Strains in Murine Infection Is Associated with International Lineage II-rep-2 and International Lineage III Clones Showing High Case Fatality Rates in Human Infections

Microorganisms, 2020
We previously reported that the 14-day case fatality rate (CFR) in patients with carbapenem-resistant Acinetobacter baumannii (CRAB) bacteremia varied between infecting clones.
Amir Nutman, Jonathan Lellouche, Ziv Lifshitz, Rivka Glick, Yehuda Carmeli   +4 more
doaj   +1 more source

Phenotypic Resistance to Antibiotics [PDF]

Antibiotics, 2013
The development of antibiotic resistance is usually associated with genetic changes, either to the acquisition of resistance genes, or to mutations in elements relevant for the activity of the antibiotic. However, in some situations resistance can be achieved without any genetic alteration; this is called phenotypic resistance. Non-inherited resistance
Fernando Corona, Jose Martinez
openaire   +4 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Seasonal variations in antibiotic resistance gene transport in the Almendares River, Havana, Cuba

, 2012
Numerous studies have quantified antibiotic resistance genes (ARG) in rivers and streams around the world, and significant relationships have been shown that relate different pollutant outputs and increased local ARG levels.
Olivares-Rieumont, Susana, Knapp, Charles, Lima, Lazaro, Emma eBowen, David eWerner, Lazaro Lima, David W. Graham, Werner, David, Charles W. Knapp, Susana Olivares-Rieumont, Emma Bowen, Charles W Knapp, Lazaro eLima, Bowen, Emma, David Werner, Graham, David W., David W eGraham, Susana eOlivares-Rieumont   +17 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Antibiotic Resistance in Selected Emerging Bacterial Foodborne Pathogens—An Issue of Concern?

, 2023
Antibiotic resistance (AR) and multidrug resistance (MDR) have been confirmed for all major foodborne pathogens: Campylobacter spp., Salmonella spp., Escherichia coli and Listeria monocytogenes.
Eugenia Gospodarek-Komkowska, Katarzyna Grudlewska-Buda, Anna Budzyńska, Krzysztof Skowron, Justyna Bauza-Kaszewska, Natalia Wiktorczyk-Kapischke   +5 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline

Nature Communications
Our understanding of the rapid adaptation of bacteria to resist novel drugs is growing beyond known mechanisms such as mobile genetic elements and mutation selection.
Jacob E. Choby, Tugba Ozturk, Carter N. Abbott, Christina Nnabuife, Jennifer M. Colquhoun, Sarah W. Satola, Philip N. Rather, Timothy Palzkill, David S. Weiss   +8 more
doaj   +1 more source

The epidemiology of carbapenem resistance in Acinetobacter baumannii complex in Germany (2014–2018): an analysis of data from the national Antimicrobial Resistance Surveillance system

Antimicrobial Resistance and Infection Control, 2021
Background Carbapenem-resistant Acinetobacter baumannii complex (CRABC) has globally emerged as a serious public health challenge. This study aimed to describe epidemiological trends and risk factors of carbapenem resistance in A.
Dunja Said, Niklas Willrich, Olaniyi Ayobami, Ines Noll, Tim Eckmanns, Robby Markwart   +5 more
doaj   +1 more source