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Carbapenem Resistance: A Review [PDF]

Medical Sciences, 2017
Carbapenem resistance is a major and an on-going public health problem globally. It occurs mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, and may be intrinsic or mediated by ...
Francis S. Codjoe, Eric S. Donkor
doaj   +3 more sources

The synergistic action of reduced membrane permeability and antibiotic sequestration as a novel mechanism for carbapenem resistance in Campylobacter [PDF]

mBio
Carbapenems are last-resort antibiotics against gram-negative pathogens, including multidrug-resistant Campylobacter. However, carbapenem-resistant Campylobacter strains are emerging and have been isolated in patients treated with carbapenems.
Xinggui Chen, Yulian Zhou, Quan Zhou, Min He, Mengyu Zhao, Suchuan Dai, Jinpeng Li, Chengyao Hou, Weilai Tao, Xinyi Yang, Shiying Lan, Xin Yang, Changwei Lei, Anyun Zhang, Hongning Wang, Yizhi Tang   +15 more
doaj   +2 more sources

Genomic Features Associated with the Degree of Phenotypic Resistance to Carbapenems in Carbapenem-Resistant Klebsiella pneumoniae

mSystems, 2021
Carbapenem-resistant Klebsiella pneumoniae strains cause severe infections that are difficult to treat. The production of carbapenemases such as the K.
Zackery P. Bulman, Fiorella Krapp, Nathan B. Pincus, Eric Wenzler, Katherine R. Murphy, Chao Qi, Egon A. Ozer, Alan R. Hauser   +7 more
doaj   +4 more sources

Mechanisms of Action of Carbapenem Resistance

Antibiotics, 2022
Carbapenem antibiotics are the most effective antimicrobials for the treatment of infections caused by the most resistant bacteria. They belong to the category of β-lactams that include the penicillins, cephalosporins, monobactams and carbapenems. This class of antimicrobials has a broader spectrum of activity than most other beta-lactams antibiotics ...
Caterina AURÍLIO, Pasquale Sansone, Manlio Barbarisi   +2 more
exaly   +4 more sources

Carbapenem resistance in the food supply chain

Journal of Food Protection, 2023
Carbapenems are critically important antibiotic agents because they are considered the “last-resort” antibiotics for treating serious infections. However, resistance to carbapenems is increasing throughout the world and has become an urgent problem. Some
En Huang, Xu Yang, Elizabeth Leighton, Xinhui Li   +3 more
doaj   +3 more sources

Concurrent Resistance to Carbapenem and Colistin Among Enterobacteriaceae Recovered From Human and Animal Sources in Nigeria Is Associated With Multiple Genetic Mechanisms

Frontiers in Microbiology, 2021
Resistance to last resort drugs such as carbapenem and colistin is a serious global health threat. This study investigated carbapenem and colistin resistance in 583 non-duplicate Enterobacteriaceae isolates utilizing phenotypic methods and whole genome ...
Emmanuel O. Ngbede, Folasade Adekanmbi, Anil Poudel, Anwar Kalalah, Patrick Kelly, Yi Yang, Andrew M. Adamu, Salem T. Daniel, Alex A. Adikwu, Chinedu A. Akwuobu, Paul O. Abba, Levi M. Mamfe, Nanven A. Maurice, Mohammed I. Adah, Olivia Lockyear, Patrick Butaye, Patrick Butaye, Chengming Wang   +17 more
doaj   +3 more sources

Reversal of carbapenem-resistance in Shewanella algae by CRISPR/Cas9 genome editing

Journal of Advanced Research, 2019
Antibiotic resistance in pathogens is a growing threat to human health. Of particular concern is resistance to carbapenem, which is an antimicrobial agent listed as critically important by the World Health Organization.
Zong-Yen Wu, Yao-Ting Huang, Wen-Cheng Chao, Shu-Peng Ho, Jan-Fang Cheng, Po-Yu Liu   +5 more
doaj   +3 more sources

Prevalence and molecular epidemiology of carbapenem-resistant Gram-negative bacilli and their resistance determinants in the Eastern Mediterranean Region over the last decade

Journal of Global Antimicrobial Resistance, 2021
: Carbapenem resistance in Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa is increasing worldwide, which has led the World Health Organization (WHO) to list these bacteria in the critical priority pathogens group.
Ahmad Sleiman, Antoine G. Abou Fayad, Hanin Banna, Ghassan M. Matar   +3 more
doaj   +3 more sources

A systematic review and meta-analysis of carbapenem resistance and its possible treatment options with focus on clinical Enterobacteriaceae: Thirty years of development in Pakistan

Heliyon
Background: Carbapenem resistance is epidemic worldwide, these last resort antimicrobials are listed in the WHO ‘watch group’ with higher resistance potential.
Muhammad Umair, Timothy R. Walsh, Mashkoor Mohsin   +2 more
doaj   +3 more sources

Carbapenem-Resistant Enterobacteriaceae [PDF]

Clinics in Laboratory Medicine, 2017
Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a major threat. Commonly used antibiotics are generally inactive against CRE. Therefore, timely detection of CRE is of paramount importance. Among CRE, those producing carbapenem-hydrolyzing β-lactamase enzymes (carbapenemase-producing Enterobacteriaceae) are particularly of concern because ...
Alina, Iovleva, Yohei, Doi
  +9 more sources