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Carbapenem Resistance: A Review [PDF]

Medical Sciences, 2017
Carbapenem resistance is a major and an on-going public health problem globally. It occurs mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, and may be intrinsic or mediated by ...
Francis S. Codjoe, Eric S. Donkor
doaj   +3 more sources

Carbapenem-Resistant Enterobacteriaceae [PDF]

Clinics in Laboratory Medicine, 2017
Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a major threat. Commonly used antibiotics are generally inactive against CRE. Therefore, timely detection of CRE is of paramount importance. Among CRE, those producing carbapenem-hydrolyzing β-lactamase enzymes (carbapenemase-producing Enterobacteriaceae) are particularly of concern because ...
Alina, Iovleva, Yohei, Doi
  +9 more sources

Prevalence and phenotypic characterization of carbapenem resistance in multidrug-resistant Gram-negative bacteria across selected healthcare facilities in the United Arab Emirates: a retrospective study. [PDF]

BMC Infect Dis
Aljaede RAM, Beshir SA, Jaber AAS, Elkalmi R, Ali ESAG, Khedr AHM, ALHamed D, Meera J, AlDeesi Z.   +8 more
europepmc   +2 more sources

Carbapenem Resistance in <i>Acinetobacter baumannii</i>: Mechanisms, Therapeutics, and Innovations. [PDF]

Microorganisms
de Souza J, D'Espindula HRS, Ribeiro IF, Gonçalves GA, Pillonetto M, Faoro H.   +5 more
europepmc   +3 more sources

The evolutionary mechanism of non-carbapenemase carbapenem-resistant phenotypes in Klebsiella spp

eLife, 2023
Antibiotic resistance is driven by selection, but the degree to which a bacterial strain’s evolutionary history shapes the mechanism and strength of resistance remains an open question.
Natalia C Rosas, Jonathan Wilksch, Jake Barber, Jiahui Li, Yanan Wang, Zhewei Sun, Andrea Rocker, Chaille T Webb, Laura Perlaza-Jiménez, Christopher J Stubenrauch, Vijaykrishna Dhanasekaran, Jiangning Song, George Taiaroa, Mark Davies, Richard A Strugnell, Qiyu Bao, Tieli Zhou, Michael J McDonald, Trevor Lithgow   +18 more
doaj   +1 more source

An overview of carbapenem-resistant organisms from food-producing animals, seafood, aquaculture, companion animals, and wildlife

Frontiers in Veterinary Science, 2023
Carbapenem resistance (CR) is a major global health concern. CR is a growing challenge in clinical settings due to its rapid dissemination and low treatment options.
Flor Y. Ramírez-Castillo, Alma L. Guerrero-Barrera, Francisco J. Avelar-González   +2 more
doaj   +1 more source

Detection of carbapenem-resistance genes in bacteria isolated from wastewater in Ontario

FACETS, 2021
Bacterial carbapenem resistance is a major public health concern since these antimicrobials are often the last resort to treat serious human infections.
Ashley L. Cooper, Cassandra Carter, Hana McLeod, Marie Wright, Prithika Sritharan, Sandeep Tamber, Alex Wong, Catherine D. Carrillo, Burton W. Blais   +8 more
doaj   +1 more source

Genomic Features Associated with the Degree of Phenotypic Resistance to Carbapenems in Carbapenem-Resistant Klebsiella pneumoniae

mSystems, 2021
Carbapenem-resistant Klebsiella pneumoniae strains cause severe infections that are difficult to treat. The production of carbapenemases such as the K.
Zackery P. Bulman, Fiorella Krapp, Nathan B. Pincus, Eric Wenzler, Katherine R. Murphy, Chao Qi, Egon A. Ozer, Alan R. Hauser   +7 more
doaj   +1 more source

Carbapenem resistance in the food supply chain

Journal of Food Protection, 2023
Carbapenems are critically important antibiotic agents because they are considered the “last-resort” antibiotics for treating serious infections. However, resistance to carbapenems is increasing throughout the world and has become an urgent problem. Some
En Huang, Xu Yang, Elizabeth Leighton, Xinhui Li   +3 more
doaj   +1 more source

Carbapenem resistance in Canada [PDF]

Canadian Medical Association Journal, 2009
For more than 2 decades, carbapenems have been considered the pharmacotherapy of last resort for managing multidrug-resistant infections caused by Enterobacteriaceae bacteria (e.g., Escherichia coli and Salmonella ).
Baldwin, Toye, Sigmund, Krajden, Milan, Fuksa, Donald E, Low, Dylan R, Pillai   +4 more
openaire   +2 more sources