Results 41 to 50 of about 2,236,849 (269)
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Scientific Reports, 2022 Carbapenemase-producing clinical isolates are becoming more common over the world, posing a severe public health danger, particularly in developing nations like India.
Namrata Kumari +7 more
doaj +1 more source
Primers encoding for carbapenem-resistance.
, 2023 Primers encoding for carbapenem-resistance.
Rael J. Too (14664679) +5 more
core +1 more source
Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae
Angewandte Chemie, EarlyView.The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray +4 more
wiley +2 more sources
BMC Microbiology, 2023 Purpose Carbapenem resistant Klebsiella pneumoniae is associated with nosocomial infections and can cause high mortality, which poses great threat to human health.
Xianzhen Wei +5 more
doaj +1 more source
Journal of Global Antimicrobial Resistance, 2021 Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary directions for Klebsiella pneumoniae, which pose a great threat in clinical settings.
Peng Lan +3 more
doaj +1 more source
Evaluation of Resistance Mechanisms in Carbapenem-Resistant Enterobacteriaceae.
Infection and drug resistance, 2020 Carbapenem-resistant Enterobacteriaceae (CRE) is a major concern leading to morbidity and mortality in the world. CRE often is becoming a cause of therapeutic failure in both hospital and community-acquired infections.This study aimed to investigate the resistance mechanisms of CRE by phenotypic and molecular methods.Sixty CRE (50 Klebsiella pneumoniae,
Alizadeh,Naser +9 more
openaire +4 more sources
, 2023 The global burden of bacterial resistance remains one of the most serious public health concerns. Infections caused by multidrug-resistant (MDR) bacteria in critically ill patients require immediate empirical treatment, which may not only be ineffective ...
Silvia De Gaetano +4 more
core +1 more source
Association of Carbapenem and Colistin Resistance in Pathogenic Gram Negative Bacteria
, 2019 Diseases caused by multidrug-resistant (MDR) bacteria continue to challenge physicians and endanger their patients’ lives. Polymyxins, including colistin, are the last resort antibiotics to treat serious infections caused by carbapenem-resistant ...
Walid Bakeer +3 more
core +1 more source
The rapid spread of carbapenem-resistant Enterobacteriaceae [PDF]
Drug Resistance Updates, 2016 Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Successful expansion of Enterobacteriaceae clonal groups and frequent horizontal gene transfer of carbapenemase expressing plasmids are causing increasing carbapenem ...
Robert F, Potter +2 more
openaire +2 more sources