Results 61 to 70 of about 2,377,546 (217)

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Recurrent Campylobacter jejuni Infections with In Vivo Selection of Resistance to Macrolides and Carbapenems: Molecular Characterization of Resistance Determinants

Microbiology Spectrum, 2023
We present two independent cases of recurrent multidrug-resistant Campylobacter jejuni infection in immunocompromised hosts and the clinical challenges encountered due to the development of high-level carbapenem resistance. The mechanisms associated with
Alexandra Nunes, Mónica Oleastro, Frederico Alves, Nadia Liassine, David M. Lowe, Lucie Benejat, Astrid Ducounau, Quentin Jehanne, Vítor Borges, João Paulo Gomes, Gauri Godbole, Lehours Philippe   +11 more
doaj   +1 more source

First genomic insights into carbapenem-resistant Klebsiella pneumoniae from Malaysia

Journal of Global Antimicrobial Resistance, 2020
Objectives: Despite the increasing reports of carbapenem-resistant Enterobacteriaceae in Malaysia, genomic resources for carbapenem-resistant clinical strains of Klebsiella pneumoniae (K. pneumoniae) remain unavailable.
Han Ming Gan, Wilhelm Wei Han Eng, Amreeta Dhanoa   +2 more
doaj   +1 more source

Carbapenem-Resistant Gram-Negative Bacilli Characterization in a Tertiary Care Center from El Bajio, Mexico

, 2023
Carbapenem-resistant Gram-negative bacilli (CR-GNB) are a major public health concern. We aimed to evaluate the prevalence of CR-GNB and the frequency of carbapenemase-encoding genes in a tertiary referral center from El Bajio, Mexico.
Juan Luis Mosqueda-Gómez, Luis Esaú López-Jacome, Luis Raúl Rivera-Garay, Claudia Adriana Colín-Castro, Rafael Franco-Cendejas, Jose Raul Nieto-Saucedo, Karina Senyase Zamarripa-Martinez, Melissa Hernández-Duran   +7 more
core   +1 more source

Carbapenem Resistance in Clinical Isolates of Enterobacteriaceae : A Global Health Concern [PDF]

, 2020
Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) has gradually emerged and is one of the serious public health concerns worldwide. Aim: To detect Carbapenem Resistance in clinical isolates of Enterobacteriaceae and Carbapenamase production by ...
Pandey, Anita, Pooja, Km., Singh, Ravi Pratap, Chauhan, Kalpana   +3 more
core   +1 more source

Molecular insights of Carbapenem resistance Klebsiella pneumoniae isolates with focus on multidrug resistance from clinical samples

Journal of Infection and Public Health, 2021
Background: Carbapenem are the last-line antibiotic, defence against Gram-negative extended spectrum ß-lactamases producers (ESBLs). Carbapenem resistance Enterobacteriaceae especially Carbapenem resistant-Klebsiella pneumoniae (CR-KP) is recognized as ...
Sureka Indrajith, Asish Kumar Mukhopadhyay, Goutam Chowdhury, Dunia A. Al Farraj, Roua M. Alkufeidy, Sivakumar Natesan, Velmurugan Meghanathan, Selvakumar Gopal, Saravanan Muthupandian   +8 more
doaj   +1 more source

Mechanism of Klebsiella pneumoniae resistance to carbapenem antibiotics [PDF]

, 2021
Purpose: To investigate the mechanism of action of Klebsiella pneumoniae (Kpn) resistance to carbapenem. Methods: The susceptibility of six Klebsiella pneumoniae strains to antibiotics was determined using KB assay.
Li, Mingyou, Lin, HanHui, Chen, Danxia, Hu, Liangshan, Zhu, Yan, Wu, Xiaoyun, Danxia Chen, Yan Zhu, Liangshan Hu, Mingyou Li, Xiaoyun Wu, HanHui Lin   +11 more
core   +1 more source

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

BlaOXA-48 Genotypic Detection of Carbapenem Resistance in Isolates of Pseudomonas Aeruginosa

Journal of Bahria University Medical and Dental College, 2021
Objective: To determine the prevalence of carbapenem resistance in strains of Pseudomonas aeruginosa at a molecular level by detecting OXA-48 gene which transcribe for resistance to the antibiotic carbapenem among indoor patients of a tertiary care ...
Shaista Bakhat, Yasmeen Taj, Faisal Hanif, Saman Nadeem   +3 more
doaj   +1 more source

Structural compatibility between β‐lactams and substrate binding pockets of IMP‐1 and NDM‐1 determines the substrate spectrum

Bulletin of the Korean Chemical Society, EarlyView.
Chemical structures of three β‐lactam classes and the substrate‐binding pockets (SBPs) of B1 metallo‐β‐lactamases (MBLs) were compared. Structural compatibility between β‐lactams and MBL SBPs correlates with enzymatic activity, providing insights into the substrate spectrum of MBLs and β‐lactam resistance.
Kiwoong Kwak, Jiwon Yun, Donghyun Lee, Byung‐Jin Lee, Juyeon Lim, Jung Hun Lee, Sang Hee Lee, Soon Young Shin, Lin‐Woo Kang   +8 more
wiley   +1 more source