Results 81 to 90 of about 48,282 (202)

Linking Antimicrobial Use and Resistance Data to Obtain a Surrogate for Appropriateness: An Approach for Assessing Carbapenem Use

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Carbapenem use is a primary target of antimicrobial stewardship programs with attempts made to limit usage to patients with suspected or documented multidrug resistant Gram-negative infections. Antimicrobial use (AU) data and the standardized
Susan Catlin, Anne Haddad, Elisia Stier, Brenda Brennan, Anurag Malani, Jason Pogue   +5 more
doaj   +1 more source

Detection of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae producing NDM-1 in Lebanon

Journal of Infection in Developing Countries, 2012
Carbapenem resistance has been encountered globally with poor outcome of infected patients. NDM-1 (New Delhi metallo-beta-lactamase) gene containing organisms have emerged and are now spreading in all continents.
Rima I El-Herte, George F Araj, Ghassan M Matar, Maysa Baroud, Zeina A Kanafani, Souha S Kanj   +5 more
doaj   +1 more source

The Synergy Between a Silver‐Ruthenium Antimicrobial and Aminoglycosides Is Based on Severe Macromolecular Damage

Molecular Microbiology, EarlyView.
AGXX enhances aminoglycoside activity against multidrug‐resistant pathogens such as uropathogenic Escherichia coli by increasing reactive oxygen species, causing protein aggregation and DNA damage. This effect is reduced by oxygen limitation or antioxidants. Polyphosphate protects cells from oxidative damage.
Emmanuel P. Oladokun, Gracious Y. Donkor, Julius K. Narh, Grady D. Jacobson, Cade Ward, Patrick O. Tawiah, Lisa K. Polzer, Kevin A. Edwards, Kyle A. Floyd, Jan‐Ulrik Dahl   +9 more
wiley   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Mechanisms of resistance to the carbapenems [PDF]

Journal of Antimicrobial Chemotherapy, 1995
D, Livingstone, M J, Gill, R, Wise
openaire   +2 more sources

Impact of Advanced Age on Posttransplant Infections and Outcomes in Solid Organ Transplant Recipients: A Multicenter Cohort Study

Transplant Infectious Disease, EarlyView.
Advanced age (≥60 years) was independently associated with higher mortality in solid organ transplant recipients, despite similar infection incidence. Even a single infection episode significantly increased mortality risk, underscoring the need for close clinical monitoring in elderly patients.
Sibel Altunisik Toplu, Vildan Avkan Oguz, Esra Tanyel, Imran Hasanoglu, Bengu Tatar, Tuba Turunc, Gule Cinar, Yesim Uygun Kizmaz, Gulnur Kul, Adem Kose, Muammer Celik, Adam Uslu, Ebru Oruc, Ezgi Erdal Karakas, Nilay Danis, Yelda Deligoz Bildaci, Sezai Yilmaz, Yasar Bayindir, Hande Arslan   +18 more
wiley   +1 more source

Perioperative Prophylaxis in Pediatric Solid Organ Transplantation: A Baseline Stewardship Audit Using Routine Electronic Data

Transplant Infectious Disease, EarlyView.
Using routine electronic data from 164 pediatric transplants, we created reproducible stewardship measures of perioperative prophylaxis practice across transplant populations and protocol pathways. Starting prophylaxis was reliable, but continuation beyond intended stop targets—especially in abdominal transplantation—identified the clearest target for ...
Charles B. Foster, Kaitlyn Rivard, Venkatraman A. Arakoni, Blanca E. Gonzalez   +3 more
wiley   +1 more source

Beta-Lactamase Gene Expression Level of Hospital-Acquired CRAB Isolated from Children in Picu

Infection and Drug Resistance, 2021
Xiao Xu,* Caifang Xu,* Rabiu Bilya Salisu, Wei Xu Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei ...
Xu X, Xu C, Salisu RB, Xu W
doaj  

AcrAB-TolC efflux pump system plays a role in carbapenem non-susceptibility in Escherichia coli

BMC Microbiology, 2019
Background Efflux pump mediated antibiotic resistance is an unnoticed and undetected mechanism in clinical microbiology laboratory. RND efflux systems are known for aminoglycoside and tetracycline resistance whereas their role in carbapenem non ...
Shiela Chetri, Deepshikha Bhowmik, Deepjyoti Paul, Piyush Pandey, Debadatta Dhar Chanda, Atanu Chakravarty, Debajyoti Bora, Amitabha Bhattacharjee   +7 more
doaj   +1 more source

Early Onset Bacteremia in Kidney Transplant Recipients in the Current Era

Transplant Infectious Disease, EarlyView.
ABSTRACT Background Bloodstream infection (BSI) after kidney transplantation increases the risk of graft loss and mortality. We aimed to identify contemporary risk factors and outcomes of early BSI (eBSI) at our transplant center. Methods We conducted a retrospective chart review of adult kidney transplant recipients (KTRs) from 2019 to 2023.
Lana Hasan, Nabin K. Shrestha, Mathew Duck, Joshua Augustine, Richard Fatica, Alvin Wee, Christine E. Koval   +6 more
wiley   +1 more source