Results 91 to 100 of about 2,236,849 (269)

Virulence Factors and Carbapenem-Resistance Mechanisms in Hypervirulent Klebsiella Pneumoniae [PDF]

Yiqun Liao,1 Junjie Gong,1 Xiaoliang Yuan,2 Xiaoling Wang,1 Yuanhong Huang,3 Xiaohong Chen1 1Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, People’s Republic of China; 2Department of Respiratory ...
Liao Y, Huang Y, Wang X, Chen X, Gong J, Yuan X   +5 more
core  

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Unveiling carbapenem resistance: mechanism and therapeutic strategies [PDF]

This review provides an overview of the carbapenem resistance, its underlying causing microbes, its mechanism of transmission, risk factors, and its treatment options and challenges. Carbapenem resistance in Gram-negative organisms such as E. coli and K.
H., Fiza S., U., Mounashree, R., Thanushree D., A., Sanjana   +3 more
core   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source

Investigation of the prevalence and role of mobile genetic elements associated with an aminoglycoside resistance gene, aacC2a, in Acinetobacter baumannii [PDF]

, 2009
Includes abstract. Includes bibliographical references (leaves 115-141)
Jongwe, Tsungai Ivai
core   +1 more source

Carbapenem Resistance in Animal-Environment-Food from Africa: A Systematic Review, Recommendations and Perspectives [PDF]

Komla Mawunyo Dossouvi,1 Ayawovi Selom Ametepe2 1Department of Microbiology, DGlobal Health Research Institute, Lomé, Togo; 2Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USACorrespondence: Komla Mawunyo Dossouvi, Tel
Ametepe AS, Dossouvi KM
core  

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

Small, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen, Matteo Tollemeto, Alexander B. Cook, Claus Sternberg, Yudong Li, Claus Moser, Lars Jelsbak, Jan C. M. Van Hest, Anja Boisen, Line Hagner Nielsen   +9 more
wiley   +1 more source

Prevalence of bla OXA-48 and other carbapenemase encoding genes among carbapenem-resistant Pseudomonas aeruginosa clinical isolates in Egypt

BMC Infectious Diseases
Background Resistance to carbapenem, the last line of treatment for gram-negative bacterial infections has been increasing globally and becoming a public health threat.
Wedad M. Abdelraheem, Doaa Elzaeem Ismail, Safaa S. Hammad   +2 more
doaj   +1 more source

Phenotypic detection of carbapenem-resistant Enterobacterales in clinical isolates at a tertiary care hospital

Journal of Current Research in Scientific Medicine
Background: In the past decade, there has been a global emergence of carbapenem-resistant Gram-negative bacilli, especially Enterobacterales. Carbapenem resistance is attributed to the ability of the bacteria to produce carbapenemases.
Astha Sinha, Mamta Gour, Riti Jain Seth
doaj   +1 more source

Isolation of carbapenem‐resistant Pseudomonas aeruginosa and other Gram‐negative ESKAPE organisms from samples of raw‐meat diets for dogs in the UK

Veterinary Record, EarlyView.
Abstract Background Gram‐negative ESKAPE organisms are an emerging threat in veterinary medicine that also have zoonotic potential. However, little is known about the prevalence and risks of these organisms in pet food. We present the incidental finding of gram‐negative ESKAPE organisms within samples of raw meat diets for dogs in the United Kingdom ...
Genever Morgan, Nicola Williams, Jenny Llewelyn, Sam Haldenby, Gina Pinchbeck, Dorina Timofte   +5 more
wiley   +1 more source