Results 111 to 120 of about 56,937 (260)

Beta-Lactamase Gene Expression Level of Hospital-Acquired CRAB Isolated from Children in Picu

Infection and Drug Resistance, 2021
Xiao Xu,* Caifang Xu,* Rabiu Bilya Salisu, Wei Xu Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei ...
Xu X, Xu C, Salisu RB, Xu W
doaj  

Mechanisms of resistance to the carbapenems [PDF]

Journal of Antimicrobial Chemotherapy, 1995
D, Livingstone, M J, Gill, R, Wise
openaire   +2 more sources

The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors

Protein Science, Volume 35, Issue 7, July 2026.
Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley   +1 more source

Impact of antibiotic use on carbapenem resistance in Pseudomonas aeruginosa: is there a role for antibiotic diversity?

, 2013
In this study, we aimed to evaluate the relationship between the rates of resistance of Pseudomonas aeruginosa to carbapenems and the levels and diversity of antibiotic consumption.
Plüss-Suard, C, Plüss-Suard, C., Zanetti, G, Kronenberg, A., Mühlemann, K, Pannatier, A, Zanetti, G., Pannatier, A., Mühlemann, K., Kronenberg, Andreas   +9 more
core   +1 more source

AcrAB-TolC efflux pump system plays a role in carbapenem non-susceptibility in Escherichia coli

BMC Microbiology, 2019
Background Efflux pump mediated antibiotic resistance is an unnoticed and undetected mechanism in clinical microbiology laboratory. RND efflux systems are known for aminoglycoside and tetracycline resistance whereas their role in carbapenem non ...
Shiela Chetri, Deepshikha Bhowmik, Deepjyoti Paul, Piyush Pandey, Debadatta Dhar Chanda, Atanu Chakravarty, Debajyoti Bora, Amitabha Bhattacharjee   +7 more
doaj   +1 more source

Polymyxin B Intravenous Administration Strategy Guided by Minimum Inhibitory Concentration in Critically Ill Patients With Pulmonary Infection: Insights From PBPK Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
PBPK/PD modeling and clinical retrospective validation of intravenous polymyxin B in critically ill patients with pulmonary infection. ABSTRACT Intravenous polymyxin B (PMB) is widely used for treating drug‐resistant gram‐negative pneumonia, though its efficacy in pulmonary infections is considered limited.
Shengnan Zhang, Nan Yang, Ruwei Yang, Yuanfang Qin, Tingting Wu, Cuifang Wu, Yueliang Xie, Jingjing Liu, Chun Liu, Qi Pei   +9 more
wiley   +1 more source

Toddlers and terriers: a One Health partnership to combat antimicrobial resistance

Journal of Small Animal Practice, EarlyView.
M. Prodanuk, F. Emdin
wiley   +1 more source

Role of Gram‐Negative Bacterial Infections in Acute‐On‐Chronic Liver Failure

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Acute‐on‐chronic liver failure (ACLF) is a systemic disease characterised by an acute clinical deterioration of pre‐existing liver cirrhosis leading to multiple organ failure due to systemic inflammation. It may be triggered by the translocation of bacteria and bacterial compounds across the gut barrier.
Camilla Cadoli, Volker Müller, Christoph Welsch, Heiko Mühl, Jonel Trebicka, Volkhard A. J. Kempf   +5 more
wiley   +1 more source

Antibiotics in Veterinary Ophthalmology: Resistance, Stewardship, and Emerging Antibiotic‐Sparing Strategies

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Antimicrobial resistance (AMR) is a growing challenge in veterinary ophthalmology, particularly in cases of bacterial keratitis, where progressive stromal infection can threaten vision and globe integrity within hours to days. This review synthesizes current evidence on pathogen distribution, antimicrobial susceptibility profiles, multidrug ...
Lionel Sebbag, Oren Pe'er
wiley   +1 more source

Carbapenem-resistant Klebsiella pneumoniae: the role of plasmids in emergence, dissemination, and evolution of a major clinical challenge

Klebsiella pneumoniae is a major agent of healthcare-associated infections and a cause of some community-acquired infections, including severe bacteremic infections associated with metastatic abscesses in liver and other organs.
Simona Pollini (304648), Marco Maria D’Andrea (8477952), Vivi Miriagou (17872074), Vincenzo Di Pilato (5807162), Gian Maria Rossolini (141530)   +4 more
core   +1 more source