Results 1 to 10 of about 4,488,232 (311)

Pharmacokinetic-pharmacodynamic integration of shikimic acid in broilers: An indirect effect modeling approach

Poultry Science
Shikimic acid (SA), a natural polyhydroxy cyclic organic acid, possesses significant anti-inflammatory and antioxidant activities; however, its pharmacokinetic (PK) profile and pharmacodynamic (PD) relationship in poultry remain poorly characterized ...
Yue Shen, Kaibin Mo, Hui Zhao, Yicheng Zhang, Xianhui Huang   +4 more
doaj   +1 more source

Modeling microbial drug-resistance: from mathematics to pharmacoeconomics

Фармакоэкономика, 2018
Complicated intra-abdominal infection (IAI) requires increased health care expenditures and additional resources to compensate for an ineffective starting therapy.Aim. To select the economically optimal algorithm for using antimicrobial agents (AMA) that
Yu. M. Gomon, M. A. Arepyeva, Yu. E. Balykina, A. S. Kolbin, A. A. Kurylev, M. A. Proskurin, S. V. Sidorenko   +6 more
doaj   +1 more source

Transfer of Infectious Drug Resistance in Microbially Defined Mice [PDF]

Journal of Bacteriology, 1969
Germ-free mice were intentionally associated with drug-resistant donor strains of Escherichia coli known to carry R factors and with drug-sensitive recipient strains. In vivo transfer of R factors was observed in all experiments, involving five different donor-recipient combinations.
N D, Reed, D G, Sieckmann, C E, Georgi
openaire   +2 more sources

Transcriptional response to the host cell environment of a multidrug-resistant Mycobacterium tuberculosis clonal outbreak Beijing strain reveals its pathogenic features

Scientific Reports, 2021
Tuberculosis is a global public health problem with emergence of multidrug-resistant infections. Previous epidemiological studies of tuberculosis in Thailand have identified a clonal outbreak multidrug-resistant strain of Mycobacterium tuberculosis in ...
Pakorn Aiewsakun, Pinidphon Prombutara, Tegar Adriansyah Putra Siregar, Thanida Laopanupong, Phongthon Kanjanasirirat, Tanawadee Khumpanied, Suparerk Borwornpinyo, Pirut Tong-Ngam, Alisa Tubsuwan, Prapaporn Srilohasin, Angkana Chaiprasert, Wuthiwat Ruangchai, Prasit Palittapongarnpim, Therdsak Prammananan, Brian C. VanderVen, Marisa Ponpuak   +15 more
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Pharmacokinetic/pharmacodynamic relationship of a novel pleuromutilin derivative APTM against Mycoplasma gallisepticum

Poultry Science
Mycoplasma gallisepticum (MG) is a primary avian pathogen that causes chronic respiratory disease, leading to significant economic losses in the poultry industry. This study aimed to investigate the pharmacokinetic/pharmacodynamic (PK/PD) relationship of
Weicong Yang, Huanzhong Ding, Xiaona Ma, Taiming Lv, Luoju Wang   +4 more
doaj   +1 more source

Advancing Antimicrobial Resistance Research Through Quantitative Modeling and Synthetic Biology

Frontiers in Bioengineering and Biotechnology, 2020
Antimicrobial resistance (AMR) is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050.
Kevin S. Farquhar, Harold Flohr, Daniel A. Charlebois   +2 more
doaj   +1 more source

Global Status of Antimicrobial Resistance and Corresponding Therapeutic Strategies

Xiehe Yixue Zazhi
With the widespread use of antimicrobial agents, the issue of microbial drug resistance has become increasingly severe, emerging as a major global public health challenge.
XU Xuesong, WANG Yao
doaj   +1 more source

Effectiveness of Adherence to Procalcitonin-Guided Antibiotic Protocol in Patients with Severe Sepsis

Pakistan Journal of Medicine and Dentistry
Background: The misuse of antibiotic therapies in hospitalized sepsis patients increases hospital length of stay and antimicrobial resistance. Procalcitonin (PCT) is a bacterial infection biomarker that can guide doctors in their decisions about ...
Awais Naeem, Aaamir Khan, Fahad Naim, Uzma Akbar, Muhammad Asif , Abdul Basit   +5 more
doaj   +1 more source

A review on lipid-based nanocarriers mimicking chylomicron and their potential in drug delivery and targeting infectious and cancerous diseases

AAPS Open, 2023
Infectious and cancerous diseases are tedious to manage. The problem of drug resistance is often associated with anti-microbial and anti-cancer agents and is one of the most significant challenges that restrict their activity.
Rana E. Elnady, Maha M. Amin, Mohamed Y. Zakaria   +2 more
doaj   +1 more source

New Delhi metallo-beta-lactamase-1-producing Acinetobacter spp. infection: report of a survivor

Revista da Sociedade Brasileira de Medicina Tropical, 2016
: New Delhi metallo-beta-lactamase-1 (NDM-1) is a bacterial enzyme that renders the bacteria resistant to a variety of beta-lactam antibiotics. A 20-year-old man was hospitalized several times for surgical treatment and complications caused by a right ...
Fabiana Schuelter-Trevisol, Graciane Jacinta Schmitt, Jane Martins de Araújo, Liliane Braga de Souza, Juliana Gomes Nazário, Raquel Landuchi Januário, Rogério Sobroza de Mello, Daisson José Trevisol   +7 more
doaj   +1 more source