Results 21 to 30 of about 202,356 (267)

Pharmacokinetic-pharmacodynamic integration of shikimic acid in broilers: An indirect effect modeling approach

Poultry Science
Shikimic acid (SA), a natural polyhydroxy cyclic organic acid, possesses significant anti-inflammatory and antioxidant activities; however, its pharmacokinetic (PK) profile and pharmacodynamic (PD) relationship in poultry remain poorly characterized ...
Yue Shen, Kaibin Mo, Hui Zhao, Yicheng Zhang, Xianhui Huang   +4 more
doaj   +1 more source

Transcriptional response to the host cell environment of a multidrug-resistant Mycobacterium tuberculosis clonal outbreak Beijing strain reveals its pathogenic features

Scientific Reports, 2021
Tuberculosis is a global public health problem with emergence of multidrug-resistant infections. Previous epidemiological studies of tuberculosis in Thailand have identified a clonal outbreak multidrug-resistant strain of Mycobacterium tuberculosis in ...
Pakorn Aiewsakun, Pinidphon Prombutara, Tegar Adriansyah Putra Siregar, Thanida Laopanupong, Phongthon Kanjanasirirat, Tanawadee Khumpanied, Suparerk Borwornpinyo, Pirut Tong-Ngam, Alisa Tubsuwan, Prapaporn Srilohasin, Angkana Chaiprasert, Wuthiwat Ruangchai, Prasit Palittapongarnpim, Therdsak Prammananan, Brian C. VanderVen, Marisa Ponpuak   +15 more
doaj   +1 more source

Pharmacokinetic/pharmacodynamic relationship of a novel pleuromutilin derivative APTM against Mycoplasma gallisepticum

Poultry Science
Mycoplasma gallisepticum (MG) is a primary avian pathogen that causes chronic respiratory disease, leading to significant economic losses in the poultry industry. This study aimed to investigate the pharmacokinetic/pharmacodynamic (PK/PD) relationship of
Weicong Yang, Huanzhong Ding, Xiaona Ma, Taiming Lv, Luoju Wang   +4 more
doaj   +1 more source

Advancing Antimicrobial Resistance Research Through Quantitative Modeling and Synthetic Biology

Frontiers in Bioengineering and Biotechnology, 2020
Antimicrobial resistance (AMR) is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050.
Kevin S. Farquhar, Harold Flohr, Daniel A. Charlebois   +2 more
doaj   +1 more source

Global Status of Antimicrobial Resistance and Corresponding Therapeutic Strategies

Xiehe Yixue Zazhi
With the widespread use of antimicrobial agents, the issue of microbial drug resistance has become increasingly severe, emerging as a major global public health challenge.
XU Xuesong, WANG Yao
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Prevalence of Extended-Spectrum β-lactamase and Integron Gene Carriage in Multidrug-Resistant Klebsiella Species Isolated from Outpatients in Yazd, Iran [PDF]

Iranian Journal of Medical Sciences, 2020
Background: Community-acquired infections by multidrug-resistant (MDR), extended-spectrum β-lactamase (ESBL) producing Klebsiella species (Klebsiella spp.) is of major concern worldwide. Antibiotic resistance, production of extended-spectrum β-lactamases
Mohammad Reza Malekjamshidi, Hengameh Zandi, Fereshteh Eftekhar   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Effectiveness of Adherence to Procalcitonin-Guided Antibiotic Protocol in Patients with Severe Sepsis

Pakistan Journal of Medicine and Dentistry
Background: The misuse of antibiotic therapies in hospitalized sepsis patients increases hospital length of stay and antimicrobial resistance. Procalcitonin (PCT) is a bacterial infection biomarker that can guide doctors in their decisions about ...
Awais Naeem, Aaamir Khan, Fahad Naim, Uzma Akbar, Muhammad Asif , Abdul Basit   +5 more
doaj   +1 more source