Results 1 to 10 of about 202,372 (256)

Predicting allostery and microbial drug resistance with molecular simulations. [PDF]

Curr Opin Struct Biol, 2018
Beta-lactamase enzymes mediate the most common forms of gram-negative antibiotic resistance affecting clinical treatment. They also constitute an excellent model system for the difficult problem of understanding how allosteric mutations can augment catalytic activity of already-competent enzymes.
Cortina GA, Kasson PM.
europepmc   +4 more sources

Microbial Persistence and the Road to Drug Resistance [PDF]

Cell Host and Microbe, 2013
Microbial drug persistence is a widespread phenomenon in which a subpopulation of microorganisms is able to survive antimicrobial treatment without acquiring resistance-conferring genetic changes. Microbial persisters can cause recurrent or intractable infections, and, like resistant mutants, they carry an increasing clinical burden.
James J Collins
exaly   +3 more sources

Geraniol-a potential alternative to antibiotics for bovine mastitis treatment without disturbing the host microbial community or causing drug residues and resistance

Frontiers in Cellular and Infection Microbiology, 2023
Mastitis is one of the most prevalent diseases of dairy cows. Currently, mastitis treatment in dairy cows is mainly based on antibiotics. However, the use of antibiotics causes adverse effects, including drug resistance, drug residues, host-microbiome ...
Wei Guo, Wei Guo, Min Qiu, Zhonghui Pu, Zhonghui Pu, Nana Long, Min Yang, Min Yang, Ke Ren, Ke Ren, Ruihong Ning, Siyuan Zhang, Siyuan Zhang, Fu Peng, Fenghui Sun, Min Dai, Min Dai   +16 more
doaj   +3 more sources

Chronic arsenic exposure and microbial drug resistance. [PDF]

Proc Natl Acad Sci U S A, 2013
Resistance to antimicrobial drugs represents one of the greatest threats to the control of infectious diseases and is a particular problem in treating diseases caused by parasitic protists. These pathogens are of enormous medical importance, causing diseases such as malaria, toxoplasmosis, trypanosomiasis, and leishmaniasis. In the absence of effective
McConville MJ, Ralph SA.
europepmc   +4 more sources

Modeling microbial drug-resistance: from mathematics to pharmacoeconomics

Фармакоэкономика, 2018
Complicated intra-abdominal infection (IAI) requires increased health care expenditures and additional resources to compensate for an ineffective starting therapy.Aim. To select the economically optimal algorithm for using antimicrobial agents (AMA) that
Yu. M. Gomon, M. A. Arepyeva, Yu. E. Balykina, A. S. Kolbin, A. A. Kurylev, M. A. Proskurin, S. V. Sidorenko   +6 more
doaj   +3 more sources

Characteristics and Evolution of Microbial Drug Resistance in Burned Patients

Journal of Burn Care and Research
Abstract Wound infection is a serious complication in burn injury, which is a common form of trauma and an important public health issue. We investigated samples from burn and nonburn wounds for microbial characteristics and temporal trends of antibiotic resistance. Wound samples were collected from 369 burned patients and 927 non-burned
Hanhua Li, Kejian Wang, Wen Lai
exaly   +3 more sources

Biocide-Resistant Escherichia coli ST540 Co-Harboring ESBL, dfrA14 Confers QnrS-Dependent Plasmid-Mediated Quinolone Resistance

Antibiotics, 2022
Emerging sequence types of pathogenic bacteria have a dual ability to acquire resistance islands/determinants, and remain renitent towards disinfection practices; therefore, they are considered “critical risk factors” that contribute significantly to the
Srinivasan Vijaya Bharathi, Govindan Rajamohan   +1 more
doaj   +1 more source

Phenotypic Characterization and Heterogeneity among Modern Clinical Isolates of Acinetobacter baumannii

Microbiology Spectrum, 2023
Acinetobacter baumannii is an opportunistic pathogenic bacterium prioritized by WHO and CDC because of its increasing antibiotic resistance. Heterogeneity among strains represents the hallmark of A. baumannii bacteria.
Adam Valcek, Chantal Philippe, Clémence Whiteway, Etienne Robino, Kristina Nesporova, Mona Bové, Tom Coenye, Tim De Pooter, Wouter De Coster, Mojca Strazisar, Charles Van der Henst   +10 more
doaj   +1 more source

Antimicrobial Activity of a Repurposed Harmine-Derived Compound on Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates

Frontiers in Cellular and Infection Microbiology, 2022
ObjectivesThe spread of antibiotic resistant bacteria is an important threat for human health. Acinetobacter baumannii bacteria impose such a major issue, as multidrug- to pandrug-resistant strains have been isolated, rendering some infections ...
Anke Breine, Anke Breine, Mégane Van Gysel, Mathias Elsocht, Clémence Whiteway, Clémence Whiteway, Chantal Philippe, Théo Quinet, Théo Quinet, Adam Valcek, Adam Valcek, Johan Wouters, Steven Ballet, Charles Van der Henst, Charles Van der Henst   +14 more
doaj   +1 more source

Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy

Pharmaceutics, 2022
Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens.
Dorina Amariucai-Mantu, Violeta Mangalagiu, Iustinian Bejan, Aculina Aricu, Ionel I. Mangalagiu   +4 more
doaj   +1 more source