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Advancing Antimicrobial Resistance Research Through Quantitative Modeling and Synthetic Biology

Frontiers in Bioengineering and Biotechnology, 2020
Antimicrobial resistance (AMR) is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050.
Kevin S. Farquhar, Harold Flohr, Daniel A. Charlebois   +2 more
doaj   +1 more source

Global Status of Antimicrobial Resistance and Corresponding Therapeutic Strategies

Xiehe Yixue Zazhi
With the widespread use of antimicrobial agents, the issue of microbial drug resistance has become increasingly severe, emerging as a major global public health challenge.
XU Xuesong, WANG Yao
doaj   +1 more source

Effectiveness of Adherence to Procalcitonin-Guided Antibiotic Protocol in Patients with Severe Sepsis

Pakistan Journal of Medicine and Dentistry
Background: The misuse of antibiotic therapies in hospitalized sepsis patients increases hospital length of stay and antimicrobial resistance. Procalcitonin (PCT) is a bacterial infection biomarker that can guide doctors in their decisions about ...
Awais Naeem, Aaamir Khan, Fahad Naim, Uzma Akbar, Muhammad Asif , Abdul Basit   +5 more
doaj   +1 more source

A review on lipid-based nanocarriers mimicking chylomicron and their potential in drug delivery and targeting infectious and cancerous diseases

AAPS Open, 2023
Infectious and cancerous diseases are tedious to manage. The problem of drug resistance is often associated with anti-microbial and anti-cancer agents and is one of the most significant challenges that restrict their activity.
Rana E. Elnady, Maha M. Amin, Mohamed Y. Zakaria   +2 more
doaj   +1 more source

Molecular studies on the impact of microbiome on anticancer drug resistance

Frontiers in Immunology
Cancer remains a leading global health challenge, with drug resistance posing a critical barrier to the durable efficacy of anticancer therapies, including chemotherapy, immunotherapy, and targeted treatments.
Ke Zhou, Ke Zhou, Ke Zhou, Ping Lu, Ping Lu, Ping Lu, Hongli Xu, Hongli Xu, Hongli Xu, Ling Wang, Xinjun Liang, Xinjun Liang, Xinjun Liang   +12 more
doaj   +1 more source

New Delhi metallo-beta-lactamase-1-producing Acinetobacter spp. infection: report of a survivor

Revista da Sociedade Brasileira de Medicina Tropical, 2016
: New Delhi metallo-beta-lactamase-1 (NDM-1) is a bacterial enzyme that renders the bacteria resistant to a variety of beta-lactam antibiotics. A 20-year-old man was hospitalized several times for surgical treatment and complications caused by a right ...
Fabiana Schuelter-Trevisol, Graciane Jacinta Schmitt, Jane Martins de Araújo, Liliane Braga de Souza, Juliana Gomes Nazário, Raquel Landuchi Januário, Rogério Sobroza de Mello, Daisson José Trevisol   +7 more
doaj   +1 more source

RESISTENCIA MICROBIANA EN EL CARDIOCENTRO ERNESTO CHE GUEVARA. ESTUDIO DE 5 AÑOS / Microbial resistance at the “Ernesto Che Guevara” Cardiology Hospital. A five year study [PDF]

CorSalud, 2009
Introduction and Objectives: The appearance of nosocomial bacterial resistance represents a problem of growing concern because it largely affects the evolution of patients and the health resources devoted to it.
Nérida Rodríguez Oliva, Rafael Gómez Marrero   +1 more
doaj  

Antimicrobial Drug Resistance in Blood Culture Isolates at a Tertiary Hospital, Uganda

Emerging Infectious Diseases, 2018
We summarize antimicrobial drug resistance (AMR) patterns from blood cultures at a tertiary hospital in Uganda. High rates of resistance to first-line antibiotic drugs were observed among Staphylococcus aureus and gram-negative organisms.
Henry Kajumbula, Ayako Wendy Fujita, Olive Mbabazi, Christine Najjuka, Charles Izale, Andrew Akampurira, Steven Aisu, Mohammed Lamorde, Richard Walwema, Nathan C. Bahr, David B. Meya, David R. Boulware, Yukari C. Manabe   +12 more
doaj   +1 more source

Endoperoxides in combating bacterial infections: synthetic pathways, mechanism, biological activity and mode of action

European Journal of Medicinal Chemistry Reports
Endoperoxides are heterocyclic compounds with a peroxide functional group embedded in one or more rings. These compounds have gathered significant interest in the last two decades owing to their biological activities and pharmaceutical relevance.
Richa Sharma, Ulrich Hennecke, Charles Van Der Henst   +2 more
doaj   +1 more source

Prevalence, Trend, and Risk Factors of Antibiotic Resistance of Klebsiella Pneumoniae in the Center of Iran During the COVID-19 Pandemic [PDF]

Epidemiology and Health System Journal
Background and aims: The emergence and spread of bacterial strains resistant to multiple antimicrobials have made the treatment of these infections increasingly challenging.
Maryam Kazemi, Mohammad Hasan Lotfi, Hengameh Zandi, Moslem Taheri Soodejani   +3 more
doaj   +1 more source