Results 31 to 40 of about 4,488,653 (302)

Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]

, 2011
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Ramage Gordon, Lopez-Ribot, J.L., Rajendran Ranjith, Ramage, G., Leah E. Cowen, Uppuluri Priya, Robbins, N., Priya Uppuluri, Rajendran, R., Andes, D., Jose L Lopez-Ribot, David Andes, Leah E Cowen, Nicole Robbins, Uppuluri, P., Robbins Nicole, Nett Jeniel, Lopez-Ribot Jose L., Jose L. Lopez-Ribot, Cowen, L.E., Nett, J., Ranjith Rajendran, Gordon Ramage, Jeniel Nett, Andes David, Cowen Leah E.   +25 more
core   +2 more sources

State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic Review

Antibiotics, 2022
Resistance to antibiotics is considered one of the most urgent global public health concerns. It has considerable impacts on health and the economy, being responsible for the failure to treat infectious diseases, higher morbidity and mortality rates, and
Hélène Meier, Keira Spinner, Lisa Crump, Esther Kuenzli, Gertraud Schuepbach, Jakob Zinsstag   +5 more
doaj   +1 more source

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S, Hastings Ian M, Dondorp Arjen M, Pongtavornpinyo Wirichada, Day Nicholas PJ, Yeung Shunmay, White Nicholas J   +26 more
core   +1 more source

Antimicrobial profile of Acinetobacter baumannii at a tertiary hospital in Honduras: a cross-sectional analysis

Revista Panamericana de Salud Pública, 2020
Acinetobacter baumannii is considered to be a worldwide threat to public health due to its high antimicrobial resistance rates and the severe infections it can cause. Little is known about this pathogen’s resistance in Central America.
Julio Cesar Zuniga-Moya, Clerk Annette Caballero, Mariela Loucel-Linares, Mayra Jazmin Benitez, Edoardo Zambrano-Garcia, Lidice Vanesa Fajardo, Julissa Stephanie Paz, Suyapa A Bejarano, Emilio Barrueto Saavedra, Luis Enrique Romero   +9 more
doaj   +1 more source

Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens

Frontiers in Pharmacology, 2021
Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to the progression of drug discovery programs.
Tushar Khare, Tushar Khare, Uttpal Anand, Abhijit Dey, Yehuda G. Assaraf, Zhe-Sheng Chen, Zhijun Liu, Vinay Kumar, Vinay Kumar   +8 more
doaj   +1 more source

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]

, 2016
Objectives The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. Methods Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Kelner, Anna, Fairlamb, Alan; id_orcid, Berriman, Matthew, Foth, Bernado J., Sokolova, Antoaneta Y., Wyllie, Susan   +5 more
core   +1 more source

Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance [PDF]

, 2004
Drug-resistant tuberculosis can be transmitted (primary) or develop during the course of treatment (secondary). We investigated risk factors for each type of resistance.
Glynn, JR, Story, A, Hayward, AC, Watson, JM, Conaty, SJ, Drobniewski, FA   +5 more
core   +1 more source

Biological properties of the major causes factors of purulently inflammatory diseases of surgical patients in Zaporizhzhia Clinical Hospital of Emergency and Critical Care Medicine

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The problem of antibiotic resistance of purulent-inflammatory diseases pathogens that arise in patients during treatment in surgery units is urgent and requires a thorough knowledge of the spectrum of circulating strains of microorganisms and changes in ...
N. M. Polishchuck, D. L. Kyryk, I. Ye. Yurchuk, O. M. Filippova, T. M. Lischenko, S. V. Yehorova   +5 more
doaj   +1 more source

Lineage-specific loss of the type VI secretion system in Acinetobacter baumannii ST19 is associated with reduced accessory genome content

Antimicrobial Agents and Chemotherapy
The type VI secretion system (T6SS) is a widespread bacterial nanomachine involved in interbacterial competition and environmental adaptation. Its distribution and evolutionary significance in Acinetobacter baumannii is not fully understood.
Adam Valcek, Diana Isabela Costescu Strachinaru, Kristina Nesporova, Patrick Soentjens, Anke Stoefs, Charles Van der Henst   +5 more
doaj   +1 more source

Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea [PDF]

, 2012
: BACKGROUND: Monitoring drug resistance in Mycobacterium tuberculosis is essential to curb the spread of tuberculosis (TB). Unfortunately, drug susceptibility testing is currently not available in Papua New Guinea (PNG) and that impairs TB control in ...
Gagneux, S., Siba Peter, Beck, H. P., Hans-Peter Beck, Beck Hans-Peter, Carter Robyn, Paul Harino, Harino, P., Carter, R., Serej Ley, Ley Serej, Siba, P., Gagneux Sebastien, Borrell Sonia, Coscolla Mireia, Mireia Coscolla, Ballif Marie, Stefan Niemann, Ley, S., Marie Ballif, Coulter, C., Robyn Carter, Coulter Christopher, Christopher Coulter, Ballif, M., Peter Siba, Niemann, S., Harino Paul, Niemann Stefan, Sebastien Gagneux, Phuanukoonnon, S., Borrell, S., Coscolla, M., Sonia Borrell, Suparat Phuanukoonnon, Phuanukoonnon Suparat   +35 more
core   +1 more source