Results 11 to 20 of about 4,768,016 (302)

Predicting allostery and microbial drug resistance with molecular simulations [PDF]

Current Opinion in Structural Biology, 2018
Beta-lactamase enzymes mediate the most common forms of gram-negative antibiotic resistance affecting clinical treatment. They also constitute an excellent model system for the difficult problem of understanding how allosteric mutations can augment catalytic activity of already-competent enzymes.
George A Cortina, Peter M Kasson
openaire   +4 more sources

Chronic arsenic exposure and microbial drug resistance [PDF]

Proceedings of the National Academy of Sciences, 2013
Resistance to antimicrobial drugs represents one of the greatest threats to the control of infectious diseases and is a particular problem in treating diseases caused by parasitic protists. These pathogens are of enormous medical importance, causing diseases such as malaria, toxoplasmosis, trypanosomiasis, and leishmaniasis. In the absence of effective
Malcolm J, McConville, Stuart A, Ralph
openaire   +3 more sources

Molecular studies on the impact of microbiome on anticancer drug resistance [PDF]

Frontiers in Immunology
Cancer remains a leading global health challenge, with drug resistance posing a critical barrier to the durable efficacy of anticancer therapies, including chemotherapy, immunotherapy, and targeted treatments.
Ke Zhou, Ke Zhou, Ke Zhou, Ping Lu, Ping Lu, Ping Lu, Hongli Xu, Hongli Xu, Hongli Xu, Ling Wang, Xinjun Liang, Xinjun Liang, Xinjun Liang   +12 more
doaj   +2 more sources

Microbial extracellular vesicles contribute to antimicrobial resistance.

PLoS Pathogens
With the escalating global antimicrobial resistance crisis, there is an urgent need for innovative strategies against drug-resistant microbes. Accumulating evidence indicates microbial extracellular vesicles (EVs) contribute to antimicrobial resistance ...
Bowei Jiang, Yi Lai, Wenhao Xiao, Tianyu Zhong, Fengping Liu, Junjie Gong, Junyun Huang   +6 more
doaj   +2 more sources

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
Sylke Müller, Hideo Imamura (62469), Dujardin, J., Khanal, Basudha, Brunker, K., Brunker, Kirstyn, Kirstyn Brunker (181178), Graham H. Coombs (164011), Suman Rijal (181185), Imamura, Hideo, Jean-Claude Dujardin, M\ufcller, Sylke, Dujardin, Jean-Claude, Dujardin, J. C., Coombs, G. H., Muller, S., Jean-Claude Dujardin (56958), Decuypere, S., Coombs, G.H., Vanaerschot, M., Decuypere, Saskia, Coombs, Graham H, Rijal, S., Manu Vanaerschot, Sylke Müller (37476), Basudha Khanal, Khanal, B., Hideo Imamura, Kirstyn Brunker, Müller, Sylke, Coombs, Graham H., Vanaerschot, Manu, Imamura, H., Rijal, Suman, Saskia Decuypere, Basudha Khanal (181181), Saskia Decuypere (181176), Manu Vanaerschot (109210), Suman Rijal, Graham H Coombs, S Decuypere   +40 more
core   +4 more sources

VIM-1, VIM-2, and GES-5 Carbapenemases Among Pseudomonas aeruginosa Isolates at a Tertiary Hospital in Istanbul, Turkey. [PDF]

, 2017
Worldwide increase in carbapenem resistance and transferable carbapenemases are significant challenges in treatment of Pseudomonas aeruginosa infections. In this study, investigation of carbapenemase production in carbapenem-resistant P.
Otlu, Barış, Bulut, Mehmet Emin, Aktaş, Elif, Bayraktar, Banu, Malkoçoğlu, Gülşah, Otlu, Baris, Malkocoglu, Guelsah   +6 more
core   +1 more source

Overcoming Multidrug Resistance of Antibiotics via Nanodelivery Systems

Pharmaceutics, 2022
Antibiotic resistance has become a threat to microbial therapies nowadays. The conventional approaches possess several limitations to combat microbial infections.
Mohammad Imran, Saurav Kumar Jha, Nazeer Hasan, Areeba Insaf, Jitendra Shrestha, Jesus Shrestha, Hari Prasad Devkota, Salman Khan, Nisha Panth, Majid Ebrahimi Warkiani, Kamal Dua, Philip M. Hansbro, Keshav Raj Paudel, Yousuf Mohammed   +13 more
doaj   +1 more source

Overview on Bacterial Resistance and Nanoparticles to Overcome Bacterial Resistance [PDF]

Journal of Advanced Pharmacy Research, 2021
Microbial infections have been the leading cause of death throughout history. This was changed when antibiotics were discovered, causing an increase in life expectancy from 48 years to 72 years. However, this golden era might end very soon. Bacteria have
Yasmin Abo-zeid, Amr Amer, Boushra El-Houssieny, Marwa Mahmoud, Wedad Sakran   +4 more
doaj   +1 more source

Inulin Can Alleviate Metabolism Disorders in ob/ob Mice by Partially Restoring Leptin-related Pathways Mediated by Gut Microbiota

Genomics, Proteomics & Bioinformatics, 2019
Inulin has been used as a prebiotic to alleviate glucose and lipid metabolism disorders in mice and humans by modulating the gut microbiota. However, the mechanism underlying the alleviation of metabolic disorders by inulin through interactions between ...
Xiaofeng Song, Liang Zhong, Na Lyu, Fei Liu, Boxing Li, Yanan Hao, Yong Xue, Jing Li, Yuqing Feng, Yue Ma, Yongfei Hu, Baoli Zhu   +11 more
doaj   +1 more source

Multimodal Role of Amino Acids in Microbial Control and Drug Development

Antibiotics, 2020
Amino acids are ubiquitous vital biomolecules found in all kinds of living organisms including those in the microbial world. They are utilised as nutrients and control many biological functions in microorganisms such as cell division, cell wall formation,
Muhammad Idrees, Afzal R. Mohammad, Nazira Karodia, Ayesha Rahman   +3 more
doaj   +1 more source