Results 21 to 30 of about 202,372 (256)

Biological properties of the major causes factors of purulently inflammatory diseases of surgical patients in Zaporizhzhia Clinical Hospital of Emergency and Critical Care Medicine

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The problem of antibiotic resistance of purulent-inflammatory diseases pathogens that arise in patients during treatment in surgery units is urgent and requires a thorough knowledge of the spectrum of circulating strains of microorganisms and changes in ...
N. M. Polishchuck, D. L. Kyryk, I. Ye. Yurchuk, O. M. Filippova, T. M. Lischenko, S. V. Yehorova   +5 more
doaj   +1 more source

Transfer of Infectious Drug Resistance in Microbially Defined Mice [PDF]

Journal of Bacteriology, 1969
Germ-free mice were intentionally associated with drug-resistant donor strains of Escherichia coli known to carry R factors and with drug-sensitive recipient strains. In vivo transfer of R factors was observed in all experiments, involving five different donor-recipient combinations.
N D, Reed, D G, Sieckmann, C E, Georgi
openaire   +2 more sources

Pharmacokinetic-pharmacodynamic integration of shikimic acid in broilers: An indirect effect modeling approach

Poultry Science
Shikimic acid (SA), a natural polyhydroxy cyclic organic acid, possesses significant anti-inflammatory and antioxidant activities; however, its pharmacokinetic (PK) profile and pharmacodynamic (PD) relationship in poultry remain poorly characterized ...
Yue Shen, Kaibin Mo, Hui Zhao, Yicheng Zhang, Xianhui Huang   +4 more
doaj   +1 more source

Transcriptional response to the host cell environment of a multidrug-resistant Mycobacterium tuberculosis clonal outbreak Beijing strain reveals its pathogenic features

Scientific Reports, 2021
Tuberculosis is a global public health problem with emergence of multidrug-resistant infections. Previous epidemiological studies of tuberculosis in Thailand have identified a clonal outbreak multidrug-resistant strain of Mycobacterium tuberculosis in ...
Pakorn Aiewsakun, Pinidphon Prombutara, Tegar Adriansyah Putra Siregar, Thanida Laopanupong, Phongthon Kanjanasirirat, Tanawadee Khumpanied, Suparerk Borwornpinyo, Pirut Tong-Ngam, Alisa Tubsuwan, Prapaporn Srilohasin, Angkana Chaiprasert, Wuthiwat Ruangchai, Prasit Palittapongarnpim, Therdsak Prammananan, Brian C. VanderVen, Marisa Ponpuak   +15 more
doaj   +1 more source

Pharmacokinetic/pharmacodynamic relationship of a novel pleuromutilin derivative APTM against Mycoplasma gallisepticum

Poultry Science
Mycoplasma gallisepticum (MG) is a primary avian pathogen that causes chronic respiratory disease, leading to significant economic losses in the poultry industry. This study aimed to investigate the pharmacokinetic/pharmacodynamic (PK/PD) relationship of
Weicong Yang, Huanzhong Ding, Xiaona Ma, Taiming Lv, Luoju Wang   +4 more
doaj   +1 more source

Advancing Antimicrobial Resistance Research Through Quantitative Modeling and Synthetic Biology

Frontiers in Bioengineering and Biotechnology, 2020
Antimicrobial resistance (AMR) is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050.
Kevin S. Farquhar, Harold Flohr, Daniel A. Charlebois   +2 more
doaj   +1 more source

Global Status of Antimicrobial Resistance and Corresponding Therapeutic Strategies

Xiehe Yixue Zazhi
With the widespread use of antimicrobial agents, the issue of microbial drug resistance has become increasingly severe, emerging as a major global public health challenge.
XU Xuesong, WANG Yao
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Prevalence of Extended-Spectrum β-lactamase and Integron Gene Carriage in Multidrug-Resistant Klebsiella Species Isolated from Outpatients in Yazd, Iran [PDF]

Iranian Journal of Medical Sciences, 2020
Background: Community-acquired infections by multidrug-resistant (MDR), extended-spectrum β-lactamase (ESBL) producing Klebsiella species (Klebsiella spp.) is of major concern worldwide. Antibiotic resistance, production of extended-spectrum β-lactamases
Mohammad Reza Malekjamshidi, Hengameh Zandi, Fereshteh Eftekhar   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source