Results 41 to 50 of about 4,768,335 (261)
_M. tuberculosis_ interactome analysis unravels potential pathways to drug resistance [PDF]
, 2008 Drug resistance is a major problem for combating tuberculosis. Lack of understanding of how resistance emerges in bacteria upon drug treatment limits our ability to counter resistance.
Nagasuma Chandra, Karthik Raman
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Transferable drug resistance plasmids in fish-pathogenic bacteria [PDF]
, 2000 Chemotherapeutic agents have been developed for treating bacterial infections and have been widely used for cultured fish for the last 30 years in Japan.
Aoki, Takashi
core +1 more source
Pakistan Journal of Medicine and DentistryBackground: The misuse of antibiotic therapies in hospitalized sepsis patients increases hospital length of stay and antimicrobial resistance. Procalcitonin (PCT) is a bacterial infection biomarker that can guide doctors in their decisions about ...
Awais Naeem +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
AAPS Open, 2023 Infectious and cancerous diseases are tedious to manage. The problem of drug resistance is often associated with anti-microbial and anti-cancer agents and is one of the most significant challenges that restrict their activity.
Rana E. Elnady +2 more
doaj +1 more source
Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]
, 2006 Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
Glasspool, R.M. +8 more
core +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi. [PDF]
, 2010 In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major ...
Grace P. McCormack +25 more
core +1 more source