Results 51 to 60 of about 4,488,232 (311)

The challenge of developing robust drugs to overcome resistance

, 2011
Drug resistance is problematic in microbial disease, viral disease and cancer. Understanding at the outset that resistance will impact the effectiveness of any new drug that is developed for these disease categories is imperative.
Schiffer, Celia A., Pollastri, Michael P., Amy C. Anderson, Peet, Norton P., Norton P. Peet, Anderson, Amy C., Celia A. Schiffer, Michael P. Pollastri   +7 more
core   +1 more source

Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]

, 2006
Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
Glasspool, R.M., Teodoridis, JM, Glasspool, RM, Teodoridis, J.M., Brown, R, R M Glasspool, Brown, R., J M Teodoridis, R Brown   +8 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

_M. tuberculosis_ interactome analysis unravels potential pathways to drug resistance [PDF]

, 2008
Drug resistance is a major problem for combating tuberculosis. Lack of understanding of how resistance emerges in bacteria upon drug treatment limits our ability to counter resistance.
Nagasuma Chandra, Karthik Raman
core  

Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi. [PDF]

, 2010
In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major ...
Grace P. McCormack, Emmanuel Banda, Judith R. Glynn, Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, French, Neil, Glynn, Judith R, Zuzanna J. Drebert, Banda, Emmanuel, Drebert, Zuzanna J., Molesworth, Anna, Vijay Bansode, Travers, Simon AA, Amelia Crampin, Drebert, Zuzanna, McCormack, Grace P, Crampin, Amelia, Anna Molesworth, Drebert, Zuzanna J, Simon A.A. Travers, Travers, Simon A A, Travers, Simon A.A., Ngwira, Bagrey, Bagrey Ngwira   +25 more
core   +1 more source

Current Research on HIV Drug Resistance [PDF]

, 2022
HIV drug resistance is an unavoidable challenge for HIV/AIDS professionals, and it has long been a major obstacle hindering the global effort to contain HIV/AIDS.

core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Updates on microbial resistance to drugs

African Journal of Microbiology Research, 2012
The treatment of bacterial infections and other microbial infections is increasingly complicated by the ability of bacteria and other microbes to develop resistance to antimicrobial agents. Microbial resistance to antimicrobial agents or chemotherapeutic agents had been attributed to their ability to bypass or overcome the various mechanisms by which ...
openaire   +1 more source