Results 81 to 90 of about 1,969,887 (183)

Predicting Antibiotic-Associated Virulence of Pseudomonas aeruginosa Using an ex vivo Lung Biofilm Model

Frontiers in Microbiology, 2020
BackgroundBacterial biofilms are known to have high antibiotic tolerance which directly affects clearance of bacterial infections in people with cystic fibrosis (CF).
Marwa M. Hassan, Marwa M. Hassan, Niamh E. Harrington, Esther Sweeney, Freya Harrison   +4 more
doaj   +1 more source

Bacterial defenses against a natural antibiotic promote collateral resilience to clinical antibiotics.

PLoS Biology, 2021
Bacterial opportunistic human pathogens frequently exhibit intrinsic antibiotic tolerance and resistance, resulting in infections that can be nearly impossible to eradicate.
Lucas A Meirelles, Elena K Perry, Megan Bergkessel, Dianne K Newman   +3 more
doaj   +1 more source

Bacterial interspecies interactions modulate pH-mediated antibiotic tolerance

eLife, 2020
Predicting antibiotic efficacy within microbial communities remains highly challenging. Interspecies interactions can impact antibiotic activity through many mechanisms, including alterations to bacterial physiology.
Andrés Aranda-Díaz, Benjamin Obadia, Ren Dodge, Tani Thomsen, Zachary F Hallberg, Zehra Tüzün Güvener, William B Ludington, Kerwyn Casey Huang   +7 more
doaj   +1 more source

Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection

Nature Microbiology, 2019
Staphylococcus aureus is a major human pathogen that causes an array of infections ranging from minor skin infections to more serious infections, including osteomyelitis, endocarditis, necrotizing pneumonia and sepsis1.
Sarah E. Rowe, N. Wagner, Lupeng Li, Jenna E. Beam, Alec D. Wilkinson, Lauren C Radlinski, Qing Zhang, Edward A. Miao, Brian P. Conlon   +8 more
semanticscholar   +1 more source

Autolysis Control Hypotheses for Tolerance to Wall Antibiotics [PDF]

Antimicrobial Agents and Chemotherapy, 2001
Antibiotics are divided into two classes: bacteriostatic and bactericidal. The reasons for their classification are usually self-evident, although seldom proven. For example, chloramphenicol stops protein synthesis and is bacteriostatic, probably because when it is removed growth can recommence.
openaire   +2 more sources

Regulating Antibiotic Tolerance within Biofilm Microcolonies [PDF]

Journal of Bacteriology, 2012
Antibiotic resistance/tolerance in biofilms is a multifactorial process. In this issue of the Journal of Bacteriology, Liao and Sauer identify the first transcriptional regulator to be linked to biofilm-specific antibiotic resistance.
openaire   +2 more sources

Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues

Nature Communications, 2019
Biofilm formation and antibiotic tolerance are regulated in Pseudomonas aeruginosa by the protein PA1396, which responds to diffusible signal factors (DSFs) produced by other bacteria. Here, An et al.
Shi-qi An, Julie Murtagh, Kate B. Twomey, Manoj K. Gupta, Timothy P. O’Sullivan, Rebecca Ingram, Miguel A. Valvano, Ji-liang Tang   +7 more
doaj   +1 more source

The Toxin-Antitoxin MazEF Drives Staphylococcus aureus Biofilm Formation, Antibiotic Tolerance, and Chronic Infection

mBio, 2019
Surgical infections are one of the most common types of infections encountered in a hospital. Staphylococcus aureus is the most common pathogen associated with this infection.
Dongzhu Ma, Jonathan B Mandell, N. Donegan, A. Cheung, Wanyan Ma, S. Rothenberger, R. Shanks, A. Richardson, K. Urish   +8 more
semanticscholar   +1 more source

Exogenous indole promotes florfenicol tolerance in Edwardsiella tarda

Virulence
Bacterial metabolism is important for antibiotic resistance and tolerance. However, the impact of indole on bacterial metabolism and antibiotic efficacy has not been fully elucidated.
Yu Zheng, Luhua Fu, Zhuoying Cao, Ting Zhang, Jiao Fei, Ming Jiang, Yuying Zhou, Zhi Shi, Yubin Su   +8 more
doaj   +1 more source

Itaconate induces tolerance of Staphylococcus aureus to aminoglycoside antibiotics

Frontiers in Microbiology
IntroductionStaphylococcus aureus is one of the chief pathogens that cause chronic and recurrent infections. Failure of the antibiotics to curb the infections contributes to relapse and is an important reason for the high mortality rate.
Runping Zhao, Lei Xu, Jieyun Chen, Jieyun Chen, Jieyun Chen, Jieyun Chen, Jieyun Chen, Yanxian Yang, Yanxian Yang, Yanxian Yang, Yanxian Yang, Yanxian Yang, Xilong Guo, Xilong Guo, Xilong Guo, Xilong Guo, Xilong Guo, Min Dai, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Li-Na Qin, Li-Na Qin   +24 more
doaj   +1 more source