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The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis [PDF]

mBio, 2022
Mycobacterium tuberculosis can cocatabolize a range of carbon sources. Fatty acids are among the carbons available inside the host’s macrophages. Here, we investigated the metabolic changes of the fatty acid-induced dormancy-like state of M. tuberculosis
Camila G. Quinonez, Jae Jin Lee, Juhyeon Lim, Mark Odell, Christopher P. Lawson, Amararachukwu Anyogu, Saki Raheem, Hyungjin Eoh   +7 more
doaj   +4 more sources

Tools to develop antibiotic combinations that target drug tolerance in Mycobacterium tuberculosis [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
Combination therapy is necessary to treat tuberculosis to decrease the rate of disease relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently needed.
Talia Greenstein, Talia Greenstein, Bree B. Aldridge, Bree B. Aldridge, Bree B. Aldridge, Bree B. Aldridge   +5 more
doaj   +2 more sources

Central carbon metabolism remodeling as a mechanism to develop drug tolerance and drug resistance in Mycobacterium tuberculosis [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Suboptimal efficacy of the current antibiotic regimens and frequent emergence of antibiotic-resistant Mycobacterium tuberculosis (Mtb), an etiological agent of tuberculosis (TB), render TB the world’s deadliest infectious disease before the COVID-19 ...
Hyungjin Eoh, Rachel Liu, Juhyeon Lim, Jae Jin Lee, Philip Sell   +4 more
doaj   +2 more sources

Decoding drug tolerance: insights into the Rv0274 gene's role in isoniazid tolerance [PDF]

Frontiers in Microbiology
IntroductionIsoniazid is widely used in the treatment of pulmonary tuberculosis, yet the mechanisms underlying its tolerance remain incompletely understood.
Min Li, Yun Wang, Xiaohong Xiang, Lingling Dong, Qiming Li, Zhou Liu, Wenwen Chu, Ye Naifang, Zhen Gong, Zhen Gong, Qiang Zhou   +10 more
doaj   +2 more sources

Ketoconazole induces reversible antifungal drug tolerance mediated by trisomy of chromosome R in Candida albicans [PDF]

Frontiers in Microbiology
BackgroundThe emergence of tolerance to antifungal agents in Candida albicans complicates the treatment of fungal infections. Understanding the mechanisms underlying this tolerance is crucial for developing effective therapeutic strategies.ObjectiveThis ...
Lijun Zheng, Yi Xu, Chen Wang, Liangsheng Guo   +3 more
doaj   +2 more sources

The Mycobacterium bovis BCG GroEL1 Contributes to Isoniazid Tolerance in a Dormant-Like State Model

Microorganisms, 2023
Due to the Mycobacterium tuberculosis complex, including M. tuberculosis and M. bovis, tuberculosis still causes 1.6 million deaths per year. Therefore, efforts to improve tuberculosis treatment are necessary. We previously showed that the GroEL1 protein
Sheng Zeng, Dong Yang, Céline Rens, Véronique Fontaine   +3 more
doaj   +1 more source

Clinical study of dynamic changes of cerebrospinal fluid cytology in drug resistant tuberculous meningitis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To summarize the dynamic changes of cerebrospinal fluid (CSF) cytology in drug resistant tuberculous meningitis (TBM), and to explore its value in drug resistance and efficacy evaluation of TBM.
CAO Dong⁃dong, KUANG Wei⁃feng , ZHANG Li⁃ting, ZHOU Li, ZHAO Si⁃qi , DUAN Hong⁃fei, XIE Jia , JIN Yan , CHEN Hai⁃ying , YE Lin , ZHANG Qi⁃long   +10 more
doaj   +1 more source

The Resolution of the Russian League Against Epilepsy Working Group Meeting (September 25, 2021, Moscow)

Эпилепсия и пароксизмальные состояния, 2022
On September 25, 2021, the Russian League Against Epilepsy (RLAE) Working Group Meeting was held regarding approaches to therapy of pediatric focal epilepsy.
article Editorial
doaj   +1 more source

Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings

Veterinary Sciences, 2022
Differences in drug tolerability among vertebrate groups and species can create substantial challenges for wildlife and ex situ conservation programmes.
Anja Wiegmann, Tony Rinaud, Meinolf Ottensmann, Oliver Krüger, Andrea Springer, Marko Legler, Michael Fehr, Christina Strube, Nayden Chakarov   +8 more
doaj   +1 more source

Mycobacterium tuberculosis Requires the Outer Membrane Lipid Phthiocerol Dimycocerosate for Starvation-Induced Antibiotic Tolerance

mSystems, 2023
Tolerance of Mycobacterium tuberculosis to antibiotics contributes to the long duration of tuberculosis (TB) treatment and the emergence of drug-resistant strains. M.
Alisha M. Block, Sarah B. Namugenyi, Nagendra P. Palani, Alyssa M. Brokaw, Leanne Zhang, Kenneth B. Beckman, Anna D. Tischler   +6 more
doaj   +1 more source