Naturally Acquired Kelch13 Mutations in Plasmodium falciparum Strains Modulate In Vitro Ring-Stage Artemisinin-Based Drug Tolerance and Parasite Survival in Response to Hyperoxia [PDF]
, 2022 The ring-stage survival assay was utilized to assess the impact of physiological hyperoxic stress on dihydroartemisinin (DHA) tolerance for a panel of Plasmodium falciparum strains with and without Kelch13 mutations.
Avery, Vicky M. +2 more
core +1 more source
Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans
Frontiers in Microbiology, 2020 Candida albicans is an important human pathogen and a major concern in intensive care units around the world. C. albicans infections are associated with a high mortality despite the use of antifungal treatments.
Eric Delarze +13 more
doaj +1 more source
The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer
Frontiers in Genetics, 2023 Ovarian cancer affects the female reproductive system and is the primary cause of cancer related mortality globally. The imprecise and non-specific nature of ovarian cancer symptoms often results in patients being diagnosed at an advanced stage, with ...
Biqing Chen +3 more
doaj +1 more source
Fatty acid metabolism of Mycobacterium tuberculosis: A double-edged sword
Microbial Cell, 2022 Unlike other heterotrophic bacteria, Mycobacterium tuberculosis (Mtb) can co-catabolize a range of carbon sources simultaneously. Evolution of Mtb within host nutrient environment allows Mtb to consume the host’s fatty acids as a main carbon source ...
Camila G. Quinonez +7 more
doaj +1 more source
Volumetric fluid analysis of fixed monthly anti-VEGF treatment in patients with neovascular age-related macular degeneration [PDF]
International Journal of Ophthalmology, 2023 AIM: To evaluate visual outcomes and changes in fluid after administering monthly anti-vascular endothelial growth factor (VEGF) injections to treat neovascular age-related macular degeneration (nAMD) with subretinal fluid (SRF) and pigment epithelial ...
Bo Hee Kim +3 more
doaj +1 more source
Efficacy and tolerability of antiseizure drugs [PDF]
Therapeutic Advances in Neurological Disorders, 2021 Drug-resistant epilepsy occurs in 25–30% of patients. Furthermore, treatment with a first-generation antiseizure drug (ASD) fails in 30–40% of individuals because of their intolerable adverse effects. Over the past three decades, 20 newer- (second- and third-)generation ASDs with unique mechanisms of action and pharmacokinetic profiles have been ...
openaire +3 more sources
Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation but not anaerobic respiration [PDF]
, 2014 Non-inherited antibiotic resistance is a phenomenon whereby a subpopulation of genetically identical bacteria displays phenotypic tolerance to antibiotics. We show that, compared to E. coli, the clinically relevant genus Burkholderia displays much higher
Butler, Clive S. +5 more
core +1 more source
Microorganisms, 2023 Mycobacterium abscessus has recently emerged as the cause of an increasing number of human infections worldwide. Unfortunately, it is highly resistant to existing drugs, and new specific agents to combat M. abscessus have not yet been found.
Andrey L. Mulyukin +7 more
doaj +1 more source
Hsp21potentiates antifungal drug tolerance in Candida albicans [PDF]
, 2013 Peer ...
Hube Bernhard +8 more
core +1 more source
Amphetamine and pseudoephedrine cross-tolerance measured by c-Fos protein expression in brains of chronically treated rats [PDF]
, 2008 Background Pseudoephedrine is a drug commonly prescribed as a nasal decongestant and bronchodilator and is also freely available in cold remedies and medications.
Tongjaroenbuangam, W. +12 more
core +4 more sources