Results 21 to 30 of about 5,956,077 (339)

Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis

Nature Communications, 2021
Tuberculosis is a chronic disease that displays several features commonly associated with biofilm-associated infections: immune system evasion, antibiotic treatment failures, and recurrence of infection. However, although Mycobacterium tuberculosis (Mtb)
Poushali Chakraborty, Sapna Bajeli, D. Kaushal, B. Radotra, Ashwani Kumar   +4 more
semanticscholar   +1 more source

Clinical study of dynamic changes of cerebrospinal fluid cytology in drug resistant tuberculous meningitis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To summarize the dynamic changes of cerebrospinal fluid (CSF) cytology in drug resistant tuberculous meningitis (TBM), and to explore its value in drug resistance and efficacy evaluation of TBM.
CAO Dong⁃dong, KUANG Wei⁃feng , ZHANG Li⁃ting, ZHOU Li, ZHAO Si⁃qi , DUAN Hong⁃fei, XIE Jia , JIN Yan , CHEN Hai⁃ying , YE Lin , ZHANG Qi⁃long   +10 more
doaj   +1 more source

The Resolution of the Russian League Against Epilepsy Working Group Meeting (September 25, 2021, Moscow)

Эпилепсия и пароксизмальные состояния, 2022
On September 25, 2021, the Russian League Against Epilepsy (RLAE) Working Group Meeting was held regarding approaches to therapy of pediatric focal epilepsy.
article Editorial
doaj   +1 more source

Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings

Veterinary Sciences, 2022
Differences in drug tolerability among vertebrate groups and species can create substantial challenges for wildlife and ex situ conservation programmes.
Anja Wiegmann, Tony Rinaud, Meinolf Ottensmann, Oliver Krüger, Andrea Springer, Marko Legler, Michael Fehr, Christina Strube, Nayden Chakarov   +8 more
doaj   +1 more source

Mycobacterium tuberculosis Requires the Outer Membrane Lipid Phthiocerol Dimycocerosate for Starvation-Induced Antibiotic Tolerance

mSystems, 2023
Tolerance of Mycobacterium tuberculosis to antibiotics contributes to the long duration of tuberculosis (TB) treatment and the emergence of drug-resistant strains. M.
Alisha M. Block, Sarah B. Namugenyi, Nagendra P. Palani, Alyssa M. Brokaw, Leanne Zhang, Kenneth B. Beckman, Anna D. Tischler   +6 more
doaj   +1 more source

Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review

Frontiers in Oncology, 2023
Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable ...
Xian-Wen Liang, Bing- Liu, Jia-Cheng Chen, Zhi Cao, Feng-ran Chu, Xiong Lin, Sheng-Zhong Wang, Jin-Cai Wu   +7 more
doaj   +1 more source

Non-walled spherical Acinetobacter baumannii is an important type of persister upon β-lactam antibiotic treatment

Emerging Microbes and Infections, 2020
Bacterial persistence is one of the major causes of antibiotic treatment failure and the step stone for antibiotic resistance. However, the mechanism by which persisters arise has not been well understood.
Jin Zou, Si-Hoi Kou, Ruiqiang Xie, Michael S. VanNieuwenhze, Jiuxin Qu, Bo Peng, Jun Zheng   +6 more
doaj   +1 more source

Impact of the CYP2D6 Genotype on Metoprolol Tolerance and Adverse Events in Elderly Chinese Patients With Cardiovascular Diseases

Frontiers in Pharmacology, 2022
The latest consensus has changed CYP2D6 genotyping among Chinese population, while its impact on metoprolol tolerance and adverse events in elderly Chinese patients with cardiovascular diseases remains unclear.
Jianqiao Chen, Jianqiao Chen, Jin Zheng, Zifan Zhu, Zifan Zhu, Benchuan Hao, Benchuan Hao, Miao Wang, Huiying Li, Huiying Li, Yulun Cai, Yulun Cai, Shiqi Wang, Jun Li, Hongbin Liu   +14 more
doaj   +1 more source

Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

Nature Communications, 2021
Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases.
A. F. Aissa, A. Islam, Majd M. Ariss, Cammille C. Go, Alexandra E. Rader, Ryan D. Conrardy, Alexa M. Gajda, C. Rubio-Perez, K. Valyi‐Nagy, M. Pasquinelli, L. Feldman, S. Green, N. López-Bigas, M. Frolov, E. Benevolenskaya   +14 more
semanticscholar   +1 more source

Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

eLife, 2023
Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C.
Vanessa Dumeaux, Samira Massahi, Van Bettauer, Austin Mottola, Anna Dukovny, Sanny Singh Khurdia, Anna Carolina Borges Pereira Costa, Raha Parvizi Omran, Shawn Simpson, Jinglin Lucy Xie, Malcolm Whiteway, Judith Berman, Michael T Hallett   +12 more
doaj   +1 more source