Results 1 to 10 of about 616,389 (323)

Host Cell Oxidative Stress Induces Dormant Staphylococcus aureus Persisters

Microbiology Spectrum, 2022
Persisters are transiently nongrowing and antibiotic-tolerant phenotypic variants identified in major human pathogens, including intracellular Staphylococcus aureus. Due to their capacity to regrow once the environmental stress is relieved and to promote
Frédéric Peyrusson, Françoise Van Bambeke   +1 more
exaly   +5 more sources

Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus, persisters and biofilms

Bioactive Materials, 2022
Methicillin-resistant Staphylococcus aureus (MRSA), biofilms, and persisters are three major factors leading to recurrent and recalcitrant implant infections. Although antibiotics are still the primary treatment for chronic implant infections in clinical,
Shutao Zhang, Xinhua Qu, Juyang Jiao
exaly   +5 more sources

Persisters, persistent infections and the Yin–Yang model

Emerging Microbes and Infections, 2014
Persisters are a small fraction of quiescent bacterial cells that survive lethal antibiotics or stresses but can regrow under appropriate conditions.
Ying Zhang
exaly   +4 more sources

Ironing out Persisters? Revisiting the Iron Chelation Strategy to Target Planktonic Bacterial Persisters Harboured in Carbapenem-Resistant Escherichia coli

Microorganisms
Antibiotic resistance is a global health crisis. Notably, carbapenem-resistant Enterobacterales (CRE) pose a significant clinical challenge due to the limited effective treatment options.
Jia Hao Yeo, Nasren Begam, Wan Ting Leow, Jia Xuan Goh, Yang Zhong, Yiying Cai, Andrea Lay-Hoon Kwa   +6 more
doaj   +3 more sources

Isolation and characterization of persisters of the pathogenic microorganism Staphylococcus aureus [PDF]

iScience, 2023
Summary: The presence of antibiotic persisters is one of the leading causes of recurrent and chronic diseases. One challenge in mechanistic research on persisters is the enrichment of pure persisters.
Shiqi Liu, Paul Laman, Sean Jensen, Nicole N. van der Wel, Gertjan Kramer, Sebastian A.J. Zaat, Stanley Brul   +6 more
doaj   +3 more sources

Single-cell Raman spectroscopy identifies Escherichia coli persisters and reveals their enhanced metabolic activities

Frontiers in Microbiology, 2022
Microbial persisters are the featured tiny sub-population of microorganisms that are highly tolerant to multiple antimicrobials. Currently, studies on persisters remain a considerable challenge owing to technical limitations.
Chuan Wang, Rongze Chen, Rongze Chen, Jian Xu, Lijian Jin   +4 more
doaj   +3 more sources

A Clinical Drug Library Screen Identifies Tosufloxacin as Being Highly Active against Staphylococcus aureus Persisters

Antibiotics, 2015
To identify effective compounds that are active against Staphylococcus aureus (S. aureus) persisters, we screened a clinical drug library consisting of 1524 compounds and identified six drug candidates that had anti-persister activity: tosufloxacin ...
Peng Cui, Rebecca Yee, Wanliang Shi
exaly   +4 more sources

Intracellular Staphylococcus aureus persisters upon antibiotic exposure

Nature Communications, 2020
International audienceBacterial persister cells are phenotypic variants that exhibit a transient non-growing state and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus persisters within infected host cells.
Tenson, Tanel, Jean-Yves Coppée, Rachel Legendre, Wolz, Christiane, Tiep Khac Nguyen, van Bambeke, Françoise, Hugo Varet, Peyrusson, Frédéric, Christiane Wolz, Sismeiro, Odile, Tanel Tenson, Legendre, Rachel, Coppée, Jean-Yves, Odile Sismeiro, Varet, Hugo, Khac Nguyen, Tiep, Françoise Van Bambeke, Frédéric Peyrusson, Nguyen, Tiep Khac   +18 more
core   +2 more sources

Persisting cancer cells are different from bacterial persisters. [PDF]

Trends in Cancer
The persistence of drug-sensitive tumors poses a significant challenge in cancer treatment. The concept of bacterial persisters, which are a subpopulation of bacteria that survive lethal antibiotic doses, is frequently used to compare to residual disease
Decollogny, Morgane, Rottenberg, Sven
core   +2 more sources

Persisters—as elusive as ever [PDF]

Applied Microbiology and Biotechnology, 2016
Persisters-a drug-tolerant sub-population in an isogenic bacterial culture-have been featured throughout the last decade due to their important role in recurrent bacterial infections.
Niilo Kaldalu, Vasili Hauryliuk, Tanel Tenson   +2 more
exaly   +2 more sources