Results 1 to 10 of about 9,566 (114)

Monocaprin, Monolaurin, and Monomyristin Eradicate Staphylococcus aureus Persister Cells Through Membrane Disruption [PDF]

Pharmaceuticals
Background/Objectives: Staphylococcus aureus persister cells significantly undermine antimicrobial therapy through their transient antibiotic tolerance, contributing to chronic and recurrent infections.
Dae-Yoon Kim, Tae-Jong Kim
doaj   +2 more sources

Overexpression of a DNA Methyltransferase Increases Persister Cell Formation in Acinetobacter baumannii

Microbiology Spectrum, 2022
Many mechanisms have been proposed to be involved in the formation of bacterial persister cells. In this study, we investigated the impact of dam encoding DNA methylation on persister cell formation in Acinetobacter.
Hyunkeun Kim, Kwan Soo Ko
exaly   +3 more sources

Ribosome State Distributions Define Escherichia coli Persister Physiology: Links to Formation, Stress Responses, and Resuscitation Dynamics [PDF]

Microbial Biotechnology
Persister cells survive antibiotic exposure and contribute to infection relapse, yet the molecular features that distinguish them from actively growing cells remain incompletely defined.
Hyein Kim, Sooyeon Song
doaj   +2 more sources

Immune Response Modulation by Pseudomonas aeruginosa Persister Cells

MBio, 2023
Bacterial persister cells—a metabolically dormant subpopulation tolerant to antimicrobials—contribute to chronic infections and are thought to evade host immunity.
Claudia N H Marques
exaly   +3 more sources

Reactive Oxygen Species Penetrate Persister Cell Membranes of Escherichia coli for Effective Cell Killing

Frontiers in Cellular and Infection Microbiology, 2020
Persister cells are difficult to eliminate because they are tolerant to antibiotic stress. In the present study, using artificially induced Escherichia coli persister cells, we found that reactive oxygen species (ROS) have greater effects on persister ...
Ryota Yamasaki, Tatsuya Sakakura, Yoshiyuki Takatsuji   +2 more
exaly   +3 more sources

Clonal dynamics shaped by diverse drug-tolerant persister states in melanoma resistance [PDF]

Molecular Cancer
Background Most advanced melanomas initially respond to targeted therapy but eventually relapse. Increasing evidence suggests that drug-tolerant persister cells can adopt a reversible drug-refractory state and represent a key driver of therapeutic ...
Haiyin Li, Yeqing Chen, Jessica Kaster, Maggie Dunne, Min Xiao, Ling Li, Monzy Thomas, Nazifa Promi, Dylan Fingerman, Gregory Schuyler Brown, Qiuxian Zheng, Xingyue Zhu, McKenna Reale, Andrew Patterson, Le Gao, Xuxiang Zhang, Siqi Jiang, Tianxing Hu, Hanzhang Fang, Jianlan Ren, Cong Qi, Luyang Wang, Haiwei Mou, Gatha Thacker, Eric Ramirez Salazar, Jessie Villanueva, Arjun Raj, Dave SB Hoon, Tian Bin, Jozef Madzo, Zhi Wei, Noam Auslander, Meenhard Herlyn   +32 more
doaj   +2 more sources

Transcription Factors of CAT1, EFG1, and BCR1 Are Effective in Persister Cells of Candida albicans-Associated HIV-Positive and Chemotherapy Patients

Frontiers in Microbiology, 2021
BackgroundBiofilm is an accumulation of cells, which are formed on mucosal surfaces of the host as well as on medical devices. The inherent resistance of Candida strains producing biofilms to antimicrobial agents is an important and key feature for ...
Elham Aboualigalehdari, Maryam Tahmasebi Birgani, Maryam Tahmasebi Birgani, Mahnaz Fatahinia, Mehran Hosseinzadeh   +4 more
doaj   +1 more source

Antimicrobial Susceptibility of Persister Biofilm Cells of Bacillus cereus and Pseudomonas fluorescens

Microorganisms, 2022
The present study evaluates the antimicrobial susceptibility of persister cells of Bacillus cereus and Pseudomonas fluorescens after their regrowth in suspension and as biofilms. Two conventional (benzalkonium chloride—BAC and peracetic acid—PAA) and two
Susana Fernandes, Inês B. Gomes, Sérgio F. Sousa, Manuel Simões   +3 more
doaj   +1 more source

A Transient Metabolic State in Melanoma Persister Cells Mediated by Chemotherapeutic Treatments

Frontiers in Molecular Biosciences, 2022
Persistence is a transient state that poses an important health concern in cancer therapy. The mechanisms associated with persister phenotypes are highly diverse and complex, and many aspects of persister cell physiology remain to be explored. We applied
Prashant Karki, Vahideh Angardi, Juan C. Mier, Mehmet A. Orman   +3 more
doaj   +1 more source

Copper Kills Escherichia coli Persister Cells

Antibiotics, 2020
Due to their reduced metabolism, persister cells can survive most antimicrobial treatments, which usually rely on corrupting active biochemical pathways.
Paula Maria Moreira Martins, Ting Gong, Alessandra A. de Souza, Thomas K. Wood   +3 more
doaj   +1 more source