Immune Response Modulation by Pseudomonas aeruginosa Persister Cells
mBio, 2023 Bacterial persister cells—a metabolically dormant subpopulation tolerant to antimicrobials—contribute to chronic infections and are thought to evade host immunity.
Cody James Hastings +3 more
doaj +3 more sources
Monocaprin, Monolaurin, and Monomyristin Eradicate Staphylococcus aureus Persister Cells Through Membrane Disruption [PDF]
PharmaceuticalsBackground/Objectives: Staphylococcus aureus persister cells significantly undermine antimicrobial therapy through their transient antibiotic tolerance, contributing to chronic and recurrent infections.
Dae-Yoon Kim, Tae-Jong Kim
doaj +2 more sources
Microbiology Spectrum, 2023 Persister cells are drug-tolerant bacteria capable of surviving antibiotic treatment despite the absence of heritable resistance mechanisms. It is generally thought that persister cells survive antibiotic exposure through the implementation of stress ...
Sebastian Braetz +4 more
doaj +3 more sources
Differential carbon source utilization drives metabolic state and resuscitation in antibiotic-tolerant persister cells [PDF]
Frontiers in PharmacologyIntroductionPersistent infections remain challenging due to dormant bacterial cells that tolerate conventional antibiotics. Specifically, persister cells, phenotypic variants characterized by high antibiotic tolerance, can resume growth once antibiotic ...
Yufei Sun +6 more
doaj +2 more sources
Dynamics associated with the efflux pumps in biofilms and persister cells of Cryptococcus neoformans and Cryptococcus gattii [PDF]
Microbiology SpectrumCryptococcosis is a systemic mycosis affecting immunocompromised individuals (mainly C. neoformans) and immunocompetent hosts (mainly C. gattii). Effective treatment remains challenging due to antifungal resistance, driven by efflux pumps, target enzyme ...
Gabriel Rezende Pimenta +6 more
doaj +2 more sources
Phage vB_KpnM_NB cocktail synergizing with amikacin in inhibiting persister cells of Klebsiella pneumoniae [PDF]
Applied and Environmental MicrobiologyThe emergence of multidrug-resistant Klebsiella pneumoniae (KPN) and antibiotic-tolerant persister cells poses a significant challenge to existing anti-infection therapies.
Bingqing Xu +8 more
doaj +2 more sources
OmpW overexpression in meropenem-exposed Acinetobacter baumannii persister cells enhances virulence and reveals a candidate target [PDF]
Frontiers in MicrobiologyObjectiveAcinetobacter baumannii is one of the most drug-resistant microorganisms in hospital-acquired infections. The treatment of choice for A. baumannii infections is carbapenems (e.g., meropenem). However, A.
Bin Liu +9 more
doaj +2 more sources
Effect of Pefloxacin on Clostridioides difficile R20291 Persister Cells Formation [PDF]
AntibioticsClostridioides difficile is a Gram-positive bacterium recognized for its ability to produce toxins and form spores. It is mainly accountable for the majority of instances of antibiotic-related diarrhea. Background.
Camila Queraltó +9 more
doaj +2 more sources
Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma [PDF]
Nature CommunicationsChemotherapy often kills a large fraction of cancer cells but leaves behind a small population of drug-tolerant persister cells. These persister cells survive drug treatments through reversible, non-genetic mechanisms and cause tumour recurrence upon ...
George L. Joun +36 more
doaj +2 more sources
Pharmacological agents targeting drug-tolerant persister cells in cancer
Pharmacological ResearchCurrent cancer therapy can be effective, but the development of drug resistant disease is the usual outcome. These drugs can eliminate most of the tumor burden but often fail to eliminate the rare, “Drug Tolerant Persister” (DTP) cell subpopulations in ...
Yu-Chi Chen +5 more
doaj +3 more sources