Monocaprin, Monolaurin, and Monomyristin Eradicate Staphylococcus aureus Persister Cells Through Membrane Disruption [PDF]
PharmaceuticalsBackground/Objectives: Staphylococcus aureus persister cells significantly undermine antimicrobial therapy through their transient antibiotic tolerance, contributing to chronic and recurrent infections.
Dae-Yoon Kim, Tae-Jong Kim
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Differential carbon source utilization drives metabolic state and resuscitation in antibiotic-tolerant persister cells [PDF]
Frontiers in PharmacologyIntroductionPersistent infections remain challenging due to dormant bacterial cells that tolerate conventional antibiotics. Specifically, persister cells, phenotypic variants characterized by high antibiotic tolerance, can resume growth once antibiotic ...
Yufei Sun +6 more
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Combatting Persister Cells With Substituted Indoles
Frontiers in Microbiology, 2020 Given that a subpopulation of most bacterial cells becomes dormant due to stress, and that the resting cells of pathogens can revive and reconstitute infections, it is imperative to find methods to treat dormant cells to eradicate infections. The dormant
Sooyeon Song, Thomas K. Wood
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Antibiotic Resistance and Presence of Persister Cells in the Biofilm-like Environments in Streptococcus agalactiae [PDF]
AntibioticsObjectives: This study investigated antibiotic resistance and presence of persister cells in Streptococcus agalactiae strains belonging to capsular types Ia/ST-103, III/ST-17, and V/ST-26 in biofilm-like environments. Results: S.
Pamella Silva Lannes-Costa +6 more
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OmpW overexpression in meropenem-exposed Acinetobacter baumannii persister cells enhances virulence and reveals a candidate target [PDF]
Frontiers in MicrobiologyObjectiveAcinetobacter baumannii is one of the most drug-resistant microorganisms in hospital-acquired infections. The treatment of choice for A. baumannii infections is carbapenems (e.g., meropenem). However, A.
Bin Liu +9 more
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Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma [PDF]
Nature CommunicationsChemotherapy often kills a large fraction of cancer cells but leaves behind a small population of drug-tolerant persister cells. These persister cells survive drug treatments through reversible, non-genetic mechanisms and cause tumour recurrence upon ...
George L. Joun +36 more
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Effect of Pefloxacin on Clostridioides difficile R20291 Persister Cells Formation [PDF]
AntibioticsClostridioides difficile is a Gram-positive bacterium recognized for its ability to produce toxins and form spores. It is mainly accountable for the majority of instances of antibiotic-related diarrhea. Background.
Camila Queraltó +9 more
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Pharmacological agents targeting drug-tolerant persister cells in cancer [PDF]
Pharmacological ResearchCurrent cancer therapy can be effective, but the development of drug resistant disease is the usual outcome. These drugs can eliminate most of the tumor burden but often fail to eliminate the rare, “Drug Tolerant Persister” (DTP) cell subpopulations in ...
Yu-Chi Chen +5 more
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Microorganisms, 2022 The present study evaluates the antimicrobial susceptibility of persister cells of Bacillus cereus and Pseudomonas fluorescens after their regrowth in suspension and as biofilms. Two conventional (benzalkonium chloride—BAC and peracetic acid—PAA) and two
Susana Fernandes +3 more
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Frontiers in Microbiology, 2021 BackgroundBiofilm is an accumulation of cells, which are formed on mucosal surfaces of the host as well as on medical devices. The inherent resistance of Candida strains producing biofilms to antimicrobial agents is an important and key feature for ...
Elham Aboualigalehdari +4 more
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