Results 21 to 30 of about 8,611 (241)
Trichosporon asahii and Trichosporon inkin Biofilms Produce Antifungal-Tolerant Persister Cells
Frontiers in Cellular and Infection Microbiology, 2021 Persister cells are metabolically inactive dormant cells that lie within microbial biofilms. They are phenotypic variants highly tolerant to antimicrobials and, therefore, associated with recalcitrant infections.
Rossana de Aguiar Cordeiro +10 more
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Persister control by leveraging dormancy associated reduction of antibiotic efflux.
PLoS Pathogens, 2021 Persistent bacterial infections do not respond to current antibiotic treatments and thus present a great medical challenge. These conditions have been linked to the formation of dormant subpopulations of bacteria, known as persister cells, that are ...
Sweta Roy +5 more
doaj +1 more source
Improving CAR T-Cell Persistence [PDF]
International Journal of Molecular Sciences, 2021 Over the last decade remarkable progress has been made in enhancing the efficacy of CAR T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in hematological settings, patients that respond to CAR T therapies remain at risk of relapsing due to several factors including poor T-cell expansion and lack of long ...
Violena Pietrobon +5 more
openaire +2 more sources
Microbiology Spectrum, 2022 Many mechanisms have been proposed to be involved in the formation of bacterial persister cells. In this study, we investigated the impact of dam encoding DNA methylation on persister cell formation in Acinetobacter.
Hyunkeun Kim +3 more
doaj +1 more source
BRAF-Inhibitor-Induced Metabolic Alterations in A375 Melanoma Cells
Metabolites, 2021 Acquired drug tolerance has been a major challenge in cancer therapy. Recent evidence has revealed the existence of slow-cycling persister cells that survive drug treatments and give rise to multi-drug-tolerant mutants in cancer.
Prashant Karki +3 more
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Universitas Scientiarum, 2020 Klebsiella pneumoniae is an opportunistic pathogen associated with nosocomial infections. Persister cells are a fraction of a bacterial population that can escape antibiotic treatment and are associated with antibiotic therapy failure.
Leonardo Posada, Iván C. Acosta, Lina Zárate, Paula Rodríguez, Mónica Gabriela Huertas, María Mercedes Zambrano
doaj +1 more source
Persistence of cefotetan on red blood cells [PDF]
Transfusion, 2004 BACKGROUND: Cefotetan can cause severe immune hemolytic anemia that may persist long after the drug is discontinued. To study the binding of cefotetan to RBCs, patients who received cefotetan were followed and tested for the presence of antibody to cefotetan.STUDY DESIGN AND METHODS: Patients receiving cefotetan were identified from pharmacy and ...
Davenport, Robertson D. +2 more
openaire +3 more sources
Phenol-Soluble Modulins Modulate Persister Cell Formation in Staphylococcus aureus
Frontiers in Microbiology, 2020 Staphylococcus aureus is a human pathogen that can cause chronic and recurrent infections and is recalcitrant to antibiotic chemotherapy. This trait is partly attributed to its ability to form persister cells, which are subpopulations of cells that are ...
Mara Baldry +6 more
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Heterogeneous persister cells formation in Acinetobacter baumannii. [PDF]
PLoS ONE, 2013 Bacterial persistence is a feature that allows susceptible bacteria to survive extreme concentrations of antibiotics and it has been verified in a number of species, such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus spp., Mycobacterium spp.
Valdir Cristóvão Barth +6 more
doaj +1 more source
High-Throughput Screening of a Promoter Library Reveals New Persister Mechanisms in Escherichia Coli
Microbiology Spectrum, 2022 Persister cells are a small subpopulation of phenotypic variants that survive high concentrations of bactericidal antibiotics. Their survival mechanisms are not heritable and can be formed stochastically or triggered by environmental stresses such as ...
Sayed Golam Mohiuddin +2 more
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