Results 21 to 30 of about 4,772,205 (283)
Frontiers in Cellular and Infection Microbiology, 2020 Persister cells are difficult to eliminate because they are tolerant to antibiotic stress. In the present study, using artificially induced Escherichia coli persister cells, we found that reactive oxygen species (ROS) have greater effects on persister ...
Aki Kawano +6 more
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Frontiers in Oncology, 2022 BackgroundDespite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives therapy failure and tumor relapse.
Xiaoli Zhang +8 more
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Persister cells and tolerance to antimicrobials [PDF]
FEMS Microbiology Letters, 2004 Bacterial populations produce persister cells that neither grow nor die in the presence of microbicidal antibiotics. Persisters are largely responsible for high levels of biofilm tolerance to antimicrobials, but virtually nothing was known about their biology.
Iris, Keren +4 more
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Bacterial persister cells tackled [PDF]
Nature, 2018 Chronic infections can be hard to treat because slow-growing bacteria known as persister cells are usually unharmed by antibiotics. The identification of molecules that target such cells might provide a solution. Chronic infections can be hard to treat because slow-growing bacteria known as persister cells are usually unharmed by antibiotics.
Julian G, Hurdle, Aditi, Deshpande
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Frontiers in Veterinary Science, 2022 Bacterial persister cells are a subpopulation of isogenic bacteria with characteristics of reduced metabolic activity and multidrug antibiotic resistance.
Guohua Jiang +10 more
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A Transient Metabolic State in Melanoma Persister Cells Mediated by Chemotherapeutic Treatments
Frontiers in Molecular Biosciences, 2022 Persistence is a transient state that poses an important health concern in cancer therapy. The mechanisms associated with persister phenotypes are highly diverse and complex, and many aspects of persister cell physiology remain to be explored. We applied
Prashant Karki +3 more
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Microbiology Spectrum, 2022 Many mechanisms have been proposed to be involved in the formation of bacterial persister cells. In this study, we investigated the impact of dam encoding DNA methylation on persister cell formation in Acinetobacter.
Hyunkeun Kim +3 more
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Improving CAR T-Cell Persistence [PDF]
International Journal of Molecular Sciences, 2021 Over the last decade remarkable progress has been made in enhancing the efficacy of CAR T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in hematological settings, patients that respond to CAR T therapies remain at risk of relapsing due to several factors including poor T-cell expansion and lack of long ...
Violena Pietrobon +5 more
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Persister control by leveraging dormancy associated reduction of antibiotic efflux.
PLoS Pathogens, 2021 Persistent bacterial infections do not respond to current antibiotic treatments and thus present a great medical challenge. These conditions have been linked to the formation of dormant subpopulations of bacteria, known as persister cells, that are ...
Sweta Roy +5 more
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Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation but not anaerobic respiration [PDF]
, 2014 Non-inherited antibiotic resistance is a phenomenon whereby a subpopulation of genetically identical bacteria displays phenotypic tolerance to antibiotics. We show that, compared to E. coli, the clinically relevant genus Burkholderia displays much higher
Butler, Clive S. +5 more
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