Results 11 to 20 of about 7,690 (295)
Isolation and characterization of persisters of the pathogenic microorganism Staphylococcus aureus [PDF]
iScienceSummary: The presence of antibiotic persisters is one of the leading causes of recurrent and chronic diseases. One challenge in mechanistic research on persisters is the enrichment of pure persisters.
Shiqi Liu +6 more
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MicroorganismsAntibiotic resistance is a global health crisis. Notably, carbapenem-resistant Enterobacterales (CRE) pose a significant clinical challenge due to the limited effective treatment options.
Jia Hao Yeo +6 more
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Inhibition of indole production increases the activity of quinolone antibiotics against E. coli persisters [PDF]
Scientific Reports, 2020 Persisters are a sub-population of genetically sensitive bacteria that survive antibiotic treatment by entering a dormant state. The emergence of persisters from dormancy after antibiotic withdrawal leads to recurrent infection.
Ashraf Zarkan +11 more
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The Synergistic Effect of Exogenous Glutamine and Rifampicin Against Mycobacterium Persisters
Frontiers in Microbiology, 2018 Persisters, stochastic dormant variants of normal bacteria cell, represent a significant portion of the survivors upon exposure to antibiotics and other environmental stresses, which contributes substantially to high level antibiotics tolerance ...
Xue Huang +12 more
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mBioDNA repair machinery has been found to be indispensable for fluoroquinolone (FQ) persistence of Escherichia coli. Previously, we found that cells harboring two copies of the chromosome (2Chr) in stationary-phase cultures were more likely to yield FQ ...
Juechun Tang +3 more
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Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy. [PDF]
PLoS ONE, 2015 Persisters are a subpopulation of normal bacterial cells that show tolerance to conventional antibiotics. Persister cells are responsible for recalcitrant chronic infections and new antibiotics effective against persisters would be a major development in
Wooseong Kim +5 more
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Characterization and Transcriptome Analysis of
mBio, 2011 Tuberculosis continues to be a major public health problem in many parts of the world. Significant obstacles in controlling the epidemic are the length of treatment and the large reservoir of latently infected people. Bacteria form dormant, drug-tolerant
Iris Keren +3 more
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Graded Persistence Diagrams and Persistence Landscapes [PDF]
Discrete & Computational Geometry, 2021 We introduce a refinement of the persistence diagram, the graded persistence diagram. It is the Mobius inversion of the graded rank function, which is obtained from the rank function using the unary numeral system. Both persistence diagrams and graded persistence diagrams are integer-valued functions on the Cartesian plane.
Leo Betthauser +2 more
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Economics & Human Biology, 2021 We ask whether mortality from historical pandemics has any predictive content for mortality in the Covid-19 pandemic. We find strong persistence in public health performance. Places that performed worse in terms of mortality in the 1918 influenza pandemic also have higher Covid-19 mortality today.
Peter Z. Lin, Christopher M. Meissner
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Persistent Persister Misperceptions [PDF]
Frontiers in Microbiology, 2016 Persister cells survive antibiotic treatment due to their lack of metabolism, rather than through genetic change, as shown via four seminal experiments conducted by the discoverers of the phenotype (Hobby et al., 1942; Bigger, 1944). Unfortunately, over seven decades of persister cell research, the literature has been populated by misperceptions that ...
Kim, Jun-Seob, Wood, Thomas K.
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