Results 11 to 20 of about 616,389 (323)
Bacterial persisters: molecular mechanisms and therapeutic development
Signal Transduction and Targeted TherapyPersisters refer to genetically drug susceptible quiescent (non-growing or slow growing) bacteria that survive in stress environments such as antibiotic exposure, acidic and starvation conditions.
Hongxia Niu, Jiaying Gu, Ying Zhang
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Salmonella persisters undermine host immune defenses during antibiotic treatment [PDF]
Science, 2018 Many bacterial infections are hard to treat and tend to relapse, possibly due to the presence of antibiotic-tolerant persisters. In vitro, persister cells appear to be dormant. After uptake of Salmonella species by macrophages, nongrowing persisters also
Fisher, Robert A +11 more
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Energy expenditure and cellular activity underlie antibiotic tolerance of Pseudomonas aeruginosa [PDF]
mBioPersisters are a subpopulation of bacterial cells that survive a lethal dose of antibiotic. The failure to treat infections has been linked to the presence of these drug-tolerant cells.
Michael F. Gates, Kim Lewis
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Plasticity, signaling, and metabolic rewiring in melanoma persister cells [PDF]
Communications BiologyDespite advances in therapy, survival rates for metastatic melanoma remain low. Drug-tolerant persister cells (persisters) can facilitate cancer recurrence, yet their characteristics and vulnerabilities differ across cancers and even within melanoma ...
Shayne Sensenbach +2 more
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The top 100 cited studies on bacterial persisters: A bibliometric analysis
Frontiers in Pharmacology, 2022 Background: Bacterial persisters are thought to be responsible for the recalcitrance and relapse of persistent infections, and they also lead to antibiotic treatment failure in clinics.
Yuan Ju, Ju Yuan
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Molecular mechanism and application of emerging technologies in study of bacterial persisters
BMC MicrobiologySince the discovery of antibiotics, they have served as a potent weapon against bacterial infections; however, natural evolution has allowed bacteria to adapt and develop coping mechanisms, ultimately leading to the concerning escalation of multidrug ...
Shuo Yuan +9 more
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Characterization and Transcriptome Analysis of
mBio, 2011 Tuberculosis continues to be a major public health problem in many parts of the world. Significant obstacles in controlling the epidemic are the length of treatment and the large reservoir of latently infected people. Bacteria form dormant, drug-tolerant
Iris Keren +3 more
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PLoS PathogensThe host environment is of critical importance for antibiotic efficacy. By impacting bacterial machineries, stresses encountered by pathogens during infection promote the formation of phenotypic variants that are transiently insensitive to the action of ...
Séverin Ronneau +3 more
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mBio, 2015 Chronic infections are a serious health care problem, and bacterial persisters have been implicated in infection reoccurrence. Progress toward finding antipersister therapies has been slow, in part because of knowledge gaps regarding the physiology of ...
Katherine G. Völzing +1 more
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Are all antibiotic persisters created equal?
Frontiers in Cellular and Infection Microbiology, 2022 Antibiotic persisters are a sub-population of bacteria able to survive in the presence of bactericidal antibiotic despite the lack of heritable drug resistance mechanisms.
Michael W. Shultis +2 more
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