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Differential impacts of DNA repair machinery on fluoroquinolone persisters with different chromosome abundances

open access: yesmBio
DNA repair machinery has been found to be indispensable for fluoroquinolone (FQ) persistence of Escherichia coli. Previously, we found that cells harboring two copies of the chromosome (2Chr) in stationary-phase cultures were more likely to yield FQ ...
Juechun Tang   +3 more
doaj   +2 more sources

Stationary-phase Pseudomonas aeruginosa fluoroquinolone persisters mostly avoid DNA double-stranded breaks [PDF]

open access: yesmSphere
When susceptible bacterial cultures are treated with antibiotics, some cells can survive treatment without heritable resistance, giving rise to susceptible daughter cells in a phenomenon termed antibiotic persistence.
Patricia J. Hare   +2 more
doaj   +2 more sources

Persisters: a distinct physiological state of E. coli

open access: yesBMC Microbiology, 2006
Background Bacterial populations contain persisters, phenotypic variants that constitute approximately 1% of cells in stationary phase and biofilm cultures.
Khodursky Arkady B   +5 more
doaj   +2 more sources

Salmonella enterica persister cells exhibit distinct susceptibility profiles following exposure to human serum and macrophages. [PDF]

open access: yesPLoS ONE
Salmonella enterica, particularly non-typhoidal serovars (NTS), is a leading cause of foodborne illness, with invasive infections posing high mortality risks in developing countries.
Rodrigo Lira Rodrigues   +8 more
doaj   +2 more sources

Bakuchiol kills Staphylococcus aureus persisters and potentiates colistin activity against Acinetobacter baumannii persisters [PDF]

open access: yesFrontiers in Pharmacology
Infections associated with bacterial persisters are challenging to cure because they can evade antibiotics and regrow, often resulting in relapse.
Kayeong Suh   +9 more
doaj   +2 more sources

Escherichia coli persisters in biofilm can perform horizontal gene transfer by transformation

open access: yesBiochemical and Biophysical Research Communications
Persisters represent a subset of cells that exhibit transient tolerance to antimicrobials. These persisters can withstand sudden exposure to antimicrobials, even as the majority of normal cells perish.
Maeda Sumio, Sumio Maeda
exaly   +2 more sources

The Synergistic Effect of Exogenous Glutamine and Rifampicin Against Mycobacterium Persisters

open access: yesFrontiers in Microbiology, 2018
Persisters, stochastic dormant variants of normal bacteria cell, represent a significant portion of the survivors upon exposure to antibiotics and other environmental stresses, which contributes substantially to high level antibiotics tolerance ...
Xue Huang   +12 more
doaj   +2 more sources

The protected physiological state of intracellular Salmonella enterica persisters reduces host cell-imposed stress

open access: yesCommunications Biology, 2021
Schulte et al. show that non-replicating Salmonella enterica serovar Typhimurium persisters, which are tolerant to antibiotics, sense their environment and respond to stressors.
Marc Schulte   +2 more
doaj   +2 more sources

Metamorphoses of Lyme disease spirochetes: phenomenon of Borrelia persisters

open access: yesParasites & Vectors, 2019
The survival of spirochetes from the Borrelia burgdorferi (sensu lato) complex in a hostile environment is achieved by the regulation of differential gene expression in response to changes in temperature, salts, nutrient content, acidity fluctuation ...
Natalie Rudenko   +3 more
doaj   +2 more sources

Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic

open access: yesNature Communications, 2019
Fluoroquinolone (FQ)-induced DNA damage in persisters could promote antibiotic resistance. Here, using time-lapse microscopy and genetic analyses, the authors show that after a single round of FQ treatment, SOS response in persisters accelerates the ...
Theresa C. Barrett   +3 more
doaj   +2 more sources

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