Results 31 to 40 of about 616,389 (323)
Frontiers in Microbiology, 2021 Microbial persisters enable the development of certain intrinsic strategies for survival with extreme tolerance to multiple antimicrobials. Porphyromonas gingivalis is considered to be the “keystone” periodontopathogen. Indeed, periodontitis, as a highly
Chuan Wang +4 more
doaj +2 more sources
Nature Communications, 2018 Persisters are bacterial subpopulations that are not killed by antibiotics even though they lack genetic resistance. Here, the authors show that persisters can manifest as small colony variants in clinical infections, and arise as a result of a long lag ...
Clément Vulin +4 more
doaj +2 more sources
Graded Persistence Diagrams and Persistence Landscapes [PDF]
Discrete & Computational Geometry, 2021 We introduce a refinement of the persistence diagram, the graded persistence diagram. It is the Mobius inversion of the graded rank function, which is obtained from the rank function using the unary numeral system. Both persistence diagrams and graded persistence diagrams are integer-valued functions on the Cartesian plane.
Leo Betthauser +2 more
openaire +2 more sources
Persistent Persister Misperceptions [PDF]
Frontiers in Microbiology, 2016 Persister cells survive antibiotic treatment due to their lack of metabolism, rather than through genetic change, as shown via four seminal experiments conducted by the discoverers of the phenotype (Hobby et al., 1942; Bigger, 1944). Unfortunately, over seven decades of persister cell research, the literature has been populated by misperceptions that ...
Kim, Jun-Seob, Wood, Thomas K.
openaire +2 more sources
Is persistent memory persistent? [PDF]
Communications of the ACM, 2020 A simple and inexpensive test of failure-atomic update mechanisms.
openaire +2 more sources
Killing of Staphylococcus aureus persisters by a multitarget natural product chrysomycin A
Science Advances, 2023 Staphylococcus aureus poses a severe public health problem as one of the vital causative agents of healthcare- and community-acquired infections. There is a globally urgent need for new drugs with a novel mode of action (MoA) to combat S. aureus biofilms
Jia Jia +15 more
semanticscholar +1 more source
Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy. [PDF]
PLoS ONE, 2015 Persisters are a subpopulation of normal bacterial cells that show tolerance to conventional antibiotics. Persister cells are responsible for recalcitrant chronic infections and new antibiotics effective against persisters would be a major development in
Wooseong Kim +5 more
doaj +1 more source
Bacterial persisters are a stochastically formed subpopulation of low-energy cells
PLoS Biology, 2021 Persisters represent a small subpopulation of non- or slow-growing bacterial cells that are tolerant to killing by antibiotics. Despite their prominent role in the recalcitrance of chronic infections to antibiotic therapy, the mechanism of their ...
S. Manuse +7 more
semanticscholar +1 more source
Persistence and anti-persistence in treadmill walking [PDF]
Gait & Posture, 2021 Abstract Background Long-range persistent correlations in stride time (ST) and length (SL) are the fundamental traits of treadmill gait. Our recent work showed that the ST and SL time series’ statistical properties originated from the superposition of large-scale trends and small-scale fluctuations ...
Klaudia Kozlowska +2 more
openaire +2 more sources
Immunocompromised Patients with Protracted COVID-19: a Review of “Long Persisters”
Current Transplantation Reports, 2022 Certain immunocompromised individuals are at risk for protracted COVID-19, in which SARS-CoV-2 leads to a chronic viral infection. However, the pathogenesis, diagnosis, and management of this phenomenon remain ill-defined.
Veronica Dioverti +2 more
semanticscholar +1 more source