Results 51 to 60 of about 616,389 (323)

Noise in a Metabolic Pathway Leads to Persister Formation in Mycobacterium tuberculosis

Microbiology Spectrum, 2022
Tuberculosis is difficult to treat due to dormant cells formed in response to immune stress and stochastically formed persisters, both of which are tolerant of antibiotics. Bactericidal antibiotics kill by corrupting their energy-dependent targets.
Jeffrey Quigley, Kim Lewis
doaj   +1 more source

Phenotypic heterogeneity in persisters: a novel ‘hunker’ theory of persistence

FEMS Microbiology Reviews, 2021
Persistence has been linked to treatment failure since its discovery over 70 years ago and understanding formation, nature and survival of this key antibiotic refractory subpopulation is crucial to enhancing treatment success and combatting the threat of
J. Urbaniec, Ye Xu, Y. Hu, S. Hingley-Wilson, J. Mcfadden   +4 more
semanticscholar   +1 more source

The drug tolerant persisters of Riemerella anatipestifer can be eradicated by a combination of two or three antibiotics

BMC Microbiology, 2018
Background Riemerella anatipestifer (RA), the causative agent of duck infectious serositis, leads to high mortality in duck flocks and great economic losses in duck industry. Previous studies on RA are largely focused on its detection, virulence factors,
Tian Tang, Yanxia Wu, Hua Lin, Yongyu Li, Haojiang Zuo, Qun Gao, Chuan Wang, Xiaofang Pei   +7 more
doaj   +1 more source

PerSort Facilitates Characterization and Elimination of Persister Subpopulation in Mycobacteria

mSystems, 2020
Mycobacterium tuberculosis (MTB) generates phenotypic diversity to persist and survive the harsh conditions encountered during infection. MTB avoids immune effectors and antibacterial killing by entering into distinct physiological states.
Vivek Srinivas, Mario L. Arrieta-Ortiz, Amardeep Kaur, Eliza J. R. Peterson, Nitin S. Baliga   +4 more
doaj   +1 more source

Nigericin is effective against multidrug resistant gram-positive bacteria, persisters, and biofilms

Frontiers in Cellular and Infection Microbiology, 2022
Multidrug-resistant (MDR) bacteria pose a significant clinical threat to human health, but the development of antibiotics cannot meet the urgent need for effective agents, especially those that can kill persisters and biofilms.
Xiaoli Zhu, Anjin Hong, Xihuan Sun, Weijie Wang, Guanghui He, Huan Luo, Zhenhua Wu, Qingyan Xu, Zhiyu Hu, Xiao-bing Wu, Donghong Huang, Li Li, Xilin Zhao, Xianming Deng   +13 more
semanticscholar   +1 more source

Persistently Finite, Persistently Arithmetic Theories [PDF]

Proceedings of the American Mathematical Society, 1983
The main result shows that a certain class of theories, the persistently finite, persistently arithmetic theories, have only arithmetic countable models.
Ash, C. J., Millar, T. S.
openaire   +2 more sources

High School Persisters and Alternative Schools

, 2022
In response to a dropout crisis, over the past decade much effort was made to retain high school students. Recent years\u27 trends indicated an overall increased level of graduation rates; however, there has been a largely overlooked student population,
Clark-Shim, Hyuny
core   +1 more source

Modulating environmental signals to reveal mechanisms and vulnerabilities of cancer persisters

Science Advances, 2022
Cancer persister cells are able to survive otherwise lethal doses of drugs through nongenetic mechanisms, which can lead to cancer regrowth and drug resistance.
Xiaoxiao Sun, Jake M. Bieber, H. Hammerlindl, R. Chalkley, Kathy Li, A. Burlingame, Matthew P. Jacobson, Lani F. Wu, S. Altschuler   +8 more
semanticscholar   +1 more source

A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. [PDF]

Nat Microbiol
Intracellular bacterial reservoirs contribute to antibiotic treatment failure by fostering metabolically dormant persister cells that are highly tolerant to killing.
Lu KY, Yang X, Eldridge MJG, Sun R, Giorgio RT, Morris BI, Wagner NJ, Hardy B, Axtman M, Rowe SE, Wang X, Fowler VG, Liu Q, Helaine S, Pearce KH, Conlon BP.   +15 more
europepmc   +2 more sources

Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics.

Cell Chemical Biology, 2020
The vast majority of bactericidal antibiotics display poor efficacy against bacterial persisters, cells that are in a metabolically repressed state. Molecules that retain their bactericidal functions against such bacteria often display toxicity to human ...
Erica J. Zheng, Jonathan M. Stokes, J. Collins   +2 more
semanticscholar   +1 more source