Results 61 to 70 of about 616,389 (323)

On the Persistence of Persistent Identifiers of the Scholarly Web [PDF]

, 2020
Scholarly resources, just like any other resources on the web, are subject to reference rot as they frequently disappear or significantly change over time. Digital Object Identifiers (DOIs) are commonplace to persistently identify scholarly resources and have become the de facto standard for citing them. We investigate the notion of persistence of DOIs
Martin Klein 0001, Lyudmila Balakireva
openaire   +2 more sources

Alternatives to Antibiotics in Animal Agriculture: An Ecoimmunological View

Pathogens, 2014
Ecological immunology (or ecoimmunology) is a new discipline in animal health and immunology that extends immunologists’ views into a natural context where animals and humans have co-evolved.
Yongming Sang, Frank Blecha
doaj   +1 more source

Resuscitation dynamics reveal persister partitioning after antibiotic treatment

Molecular Systems Biology, 2023
Bacteria can survive antibiotics by forming dormant, drug‐tolerant persisters. Persisters can resuscitate from dormancy after treatment and prolong infections.
Xin Fang, Kyle R Allison
doaj   +1 more source

In vitro potency of 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione against drug-resistant and non-replicating persisters of Mycobacterium tuberculosis

Journal of Global Antimicrobial Resistance, 2021
: Objectives: New antituberculosis agents active against drug-resistant and non-replicating tubercle bacilli are required. We evaluated a previously identified hit, 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione (PAMCHD ...
Muzafar Ahmad Rather, Zubair Shanib Bhat, Ali Mohd Lone, Mubashir Maqbool, Bilal Ahmad Bhat, Zahoor Ahmad   +5 more
doaj   +1 more source

Characterising mycobacterial persisters.

, 2019
Treatment of tuberculosis requires multiple drugs and takes 6-9 months. The lengthy treatment has been mainly attributed to the pre-existing population of bacteria that are tolerant to the antibiotics, but not genetically resistant, known as persisters ...
Hernandez, Johana E.
core   +1 more source

Plasmodium malariae: the persisting mysteries of a persistent parasite

Trends in Parasitology, 2023
Plasmodium malariae is a 'neglected malaria parasite' in as much as the amount of research conducted on it pales into insignificance when compared to that pertaining to Plasmodium falciparum and Plasmodium vivax, its more notorious and pathogenic cousins.
Culleton, Richard, Pain, Arnab, Snounou, Georges   +2 more
openaire   +3 more sources

Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis

Nature Communications, 2022
Antibiotic persisters are phenotypic variants within an isogenic bacterial population that are transiently tolerant to antibiotic treatment. Here, the authors provide evidence that cytoplasmic acidification, amplified by a compromised respiratory complex
Bram Van den Bergh, Hannah Schramke, Joran Elie Michiels, Tom E. P. Kimkes, Jakub Leszek Radzikowski, Johannes Schimpf, Silke R. Vedelaar, Sabrina Burschel, Liselot Dewachter, Nikola Lončar, Alexander Schmidt, Tim Meijer, Maarten Fauvart, Thorsten Friedrich, Jan Michiels, Matthias Heinemann   +15 more
doaj   +1 more source

Persistent URIs Must Be Used To Be Persistent [PDF]

Proceedings of the 25th International Conference Companion on World Wide Web - WWW '16 Companion, 2016
2 pages, 2 figures, accepted for publication at WWW 2016 (poster track)
Herbert Van de Sompel, Martin Klein 0001, Shawn M. Jones   +2 more
openaire   +2 more sources

Protocol for high-throughput isolation of bacterial intracellular nonreplicating persisters v1

, 2023
International audienceFailure of antibiotics to clear a bacterial infection is arguably one of the most severe threat to global health. Bacteria ability to withstand drug treatment partly relies on the formation of a subpopulation of persisters ...
Personnic, Nicolas, Huguet, Kevin, Dadole, Iris, Blaha, Didier   +3 more
core   +1 more source

Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse

Cell Reports Medicine
Summary Drug-tolerant persisters (DTPs) are a rare subpopulation of cells within a tumor that can survive therapy through nongenetic adaptive mechanisms to develop relapse and repopulate the tumor following drug withdrawal.
Mengnuo Chen, S. Mainardi, C. Lieftink, A. Velds, Iris de Rink, Chen Yang, H. J. Kuiken, B. Morris, Finn Edwards, F. Jochems, O. van Tellingen, Manon Boeije, Natalie Proost, Robin A Jansen, S. Qin, Haojie Jin, J.C. Koen van der Mijn, A. Schepers, Subramanian Venkatesan, Wenxin Qin, R. Beijersbergen, Liqin Wang, René Bernards   +22 more
semanticscholar   +1 more source