Results 1 to 10 of about 422,605 (335)

The metabolic consequences of HIV/TB co-infection

BMC Infectious Diseases, 2023
Background The synergy between the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis during co-infection of a host is well known. While this synergy is known to be driven by immunological deterioration, the metabolic mechanisms that ...
Chandré Herbert, Laneke Luies, Du Toit Loots, Aurelia A. Williams   +3 more
doaj   +1 more source

HIV-1 Tat amino acid residues that influence Tat-TAR binding affinity: a scoping review

BMC Infectious Diseases, 2023
HIV-1 remains a global health concern and to date, nearly 38 million people are living with HIV. The complexity of HIV-1 pathogenesis and its subsequent prevalence is influenced by several factors including the HIV-1 subtype.
Piwai Terry Gotora, Rencia van der Sluis, Monray Edward Williams   +2 more
doaj   +1 more source

Optimising a urinary extraction method for non-targeted GC–MS metabolomics

Scientific Reports, 2023
Urine is ideal for non-targeted metabolomics, providing valuable insights into normal and pathological cellular processes. Optimal extraction is critical since non-targeted metabolomics aims to analyse various compound classes.
Cara Olivier, Bianca Allen, Laneke Luies
doaj   +1 more source

Transcriptionally imprinted glycomic signatures of acute myeloid leukemia

Cell & Bioscience, 2023
Background Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous disease that has been suffering from stagnant survival curves for decades.
Constantin Blöchl, Di Wang, Oleg A. Mayboroda, Guinevere S. M. Lageveen-Kammeijer, Manfred Wuhrer   +4 more
doaj   +1 more source

The advantages of rare disease biobanking: A localised source of genetic knowledge to benefit the South African rare disease community and related stakeholders worldwide

South African Medical Journal, 2023
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M Dercksen, E H Conradie, C J Hendriksz, H Malherbe, B C Vorster   +4 more
doaj   +1 more source

In Silico Drug Discovery Strategies Identified ADMET Properties of Decoquinate RMB041 and Its Potential Drug Targets against Mycobacterium tuberculosis

Microbiology Spectrum, 2022
The highly adaptive cellular response of Mycobacterium tuberculosis to various antibiotics and the high costs for clinical trials, hampers the development of novel antimicrobial agents with improved efficacy and safety.
Kirsten E. Knoll, Mietha M. van der Walt, Du Toit Loots   +2 more
doaj   +1 more source

Mapping an atlas of tissue-specific drosophila melanogaster metabolomes by high resolution mass spectrometry [PDF]

, 2013
Metabolomics can provide exciting insights into organismal function, but most work on simple models has focussed on the whole organism metabolome, so missing the contributions of individual tissues.
A Kamleh, A Malmendal, A Malmendal, AA Jackson, C Jeulin, David G. Watson, DG Watson, DJ Creek, Dominika Korzekwa, DT Sullivan, G Di Paolo, G Fraenkel, GJ Blomquist, GX Quan, H Colinet, J Andrews, J Overgaard, Jacob Guy Bundy, JD Feala, JE Treherne, JL Hubby, JS Park, Julian A. T. Dow, KS Pedersen, L Coquin, L Pan, L Zheng, M Carvalho, M Parisi, M Rera, MA Kamleh, MA Kamleh, MF Wolfner, MM Green, Mohammed Al Bratty, MS Elias, N Vereshchagina, NE Braverman, P Niewiadomska, PA Robitaille, PS Shekhawat, R Tearle, S Buch, S Reisse, V Kostal, Venkateswara R. Chintapalli, VR Chintapalli, VR Chintapalli   +47 more
core   +6 more sources

Analysis of adherent cell culture lysates with low metabolite concentrations using the Biocrates AbsoluteIDQ p400 HR kit

Scientific Reports, 2022
The AbsoluteIDQ p400 HR kit is a commercial product for targeted metabolomics. While the kit has been validated for human plasma and serum, adherent cell lysates have not yet been evaluated.
Raphaela Fritsche-Guenther, Yoann Gloaguen, Alina Eisenberger, Jennifer A. Kirwan   +3 more
doaj   +1 more source

Statistical Workflow for Feature Selection in Human Metabolomics Data. [PDF]

, 2019
High-throughput metabolomics investigations, when conducted in large human cohorts, represent a potentially powerful tool for elucidating the biochemical diversity underlying human health and disease.
Antonelli, Joseph, Cheng, Susan, Claggett, Brian L, Demler, Olga V, Deng, Katherine, Henglin, Mir, Hushcha, Pavel V, Jain, Mohit, Kim, Andy, Kim, Nicole, Lagerborg, Kim A, Mora, Samia, Niiranen, Teemu J, Ovsak, Gavin, Pereira, Alexandre C, Rao, Kevin, Tyagi, Octavia, Watrous, Jeramie D   +17 more
core   +2 more sources

Metabolite profiling of susceptible and resistant wheat (Triticum aestivum) cultivars responding to Puccinia striiformis f. sp. tritici infection

BMC Plant Biology, 2023
Background Puccinia striiformis f. sp. tritici (Pst) is an economically devasting disease that is prominent in cereal crops such as wheat (Triticum aestivum). The fungal pathogen can cause approximately 30–70% losses in crop productivity and yields.
Manamele Dannies Mashabela, Fidele Tugizimana, Paul Anton Steenkamp, Lizelle Ann Piater, Ian Augustus Dubery, Msizi Innocent Mhlongo   +5 more
doaj   +1 more source