Results 41 to 50 of about 172,987 (269)

Characterization of In-House Produced Mono- and Polyclonal Antibodies Against Soy for Component-Resolved Allergen Analysis

Journal of Food Quality
In recent years, food allergies have emerged as a significant global health concern that affect an increasing percentage of the population. Despite being under investigation and discussed as a major or minor elicitor of food allergies, soybean remains a ...
Michael Wiederstein, Manuela Fuehrer, Kathrin Lauter, Sabine Baumgartner   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Metabolomics for the masses: The future of metabolomics in a personalized world

European Journal of Molecular & Clinical Medicine, 2017
Current clinical practices focus on a small number of biochemical directly related to the pathophysiology with patients and thus only describe a very limited metabolome of a patient and fail to consider the interations of these small molecules.
Trivedi, Drupad; id_orcid 0000-0001-7969-0195, Hollywood, Katherine; id_orcid 0000-0002-7028-047X, Goodacre, Royston   +2 more
openaire   +4 more sources

Targeted Metabolomics [PDF]

Current Protocols in Molecular Biology, 2012
AbstractThe metabolome is the terminal downstream product of the genome and consists of the total complement of all the low‐molecular‐weight molecules (metabolites) in a cell, tissue, or organism. Metabolomics aims to measure a wide breadth of small molecules in the context of physiological stimuli or disease states.
Lee D, Roberts, Amanda L, Souza, Robert E, Gerszten, Clary B, Clish   +3 more
openaire   +2 more sources

Data on the optimisation of a solid phase extraction method for fractionating estrogen metabolites from small urine volumes

Data in Brief, 2020
Certain estrogen metabolites have been implicated in the pathophysiology of breast cancer. Moreover, the estrogen metabolite profiles of healthy women and those with (a high risk of) breast cancer differ significantly.
Carien L. van der Berg, Gerda Venter, Francois H. van der Westhuizen, Elardus Erasmus   +3 more
doaj   +1 more source

Beetroot juice — a suitable post-marathon metabolic recovery supplement?

Journal of the International Society of Sports Nutrition, 2021
Background Red beetroot (Beta vulgaris L.) is a multifunctional functional food that reportedly exhibits potent anti-inflammatory, antioxidant, vasodilation, and cellular regulatory properties.
Zinandré Stander, Laneke Luies, Mari van Reenen, Glyn Howatson, Karen M. Keane, Tom Clifford, Emma J. Stevenson, Du Toit Loots   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Metabolomics in oncology

Cancer Reports, 2023
AbstractBackgroundOncogenic transformation alters intracellular metabolism and contributes to the growth of malignant cells. Metabolomics, or the study of small molecules, can reveal insight about cancer progression that other biomarker studies cannot.
Gurparsad Singh Suri, Gurleen Kaur, Giuseppina M. Carbone, Dheeraj Shinde   +3 more
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

3,4-dimethoxychalcone induces autophagy and reduces neointimal hyperplasia and aortic lesions in mouse models of atherosclerosis

Cell Death and Disease, 2023
Autophagy inducers can prevent cardiovascular aging and age-associated diseases including atherosclerosis. Therefore, we hypothesized that autophagy-inducing compounds that act on atherosclerosis-relevant cells might have a protective role in the ...
Giulia Cerrato, Carlota Alvarez-Lucena, Allan Sauvat, Yanhua Hu, Sabrina Forveille, Guo Chen, Sylvère Durand, Fanny Aprahamian, Marion Leduc, Omar Motiño, Lisardo Boscá, Qingbo Xu, Oliver Kepp, Guido Kroemer   +13 more
doaj   +1 more source