Results 21 to 30 of about 170,741 (219)

Differences in the Stool Metabolome between Vegans and Omnivores: Analyzing the NIST Stool Reference Material

open access: yesMetabolites, 2023
To gain confidence in results of omic-data acquisitions, methods must be benchmarked using validated quality control materials. We report data combining both untargeted and targeted metabolomics assays for the analysis of four new human fecal reference ...
Raquel Cumeras   +5 more
doaj   +1 more source

Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples

open access: yesNature Communications, 2019
In-depth characterization of complex glycomes is complicated by the immense structural diversity of glycans. Here, the authors present a mass spectrometry-based strategy for untargeted, sensitive glycan profiling and identify 167 N-glycan compositions in
Guinevere S. M. Lageveen-Kammeijer   +7 more
doaj   +1 more source

A Comparison of the Genotoxic Effects of Gold Nanoparticles Functionalized with Seven Different Ligands in Cultured Human Hepatocellular Carcinoma Cells

open access: yesNanomaterials, 2022
Gold nanoparticles (GNPs) have shown great potential in diagnostic and therapeutic applications in diseases, such as cancer. Despite GNP versatility, there is conflicting data regarding the toxicity of their overall functionalization chemistry for ...
Danielle Mulder   +3 more
doaj   +1 more source

The METLIN small molecule dataset for machine learning-based retention time prediction

open access: yesNature Communications, 2019
The use of machine learning for identifying small molecules through their retention time’s predictions has been challenging so far. Here the authors combine a large database of liquid chromatography retention time with a deep learning approach to enable ...
Xavier Domingo-Almenara   +8 more
doaj   +1 more source

Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance

open access: yesOncoImmunology, 2023
In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of ...
Marine Fidelle   +3 more
doaj   +1 more source

SECIMTools: a suite of metabolomics data analysis tools

open access: yesBMC Bioinformatics, 2018
Background Metabolomics has the promise to transform the area of personalized medicine with the rapid development of high throughput technology for untargeted analysis of metabolites.
Alexander S. Kirpich   +8 more
doaj   +1 more source

Altered metabolomic states elicited by Flg22 and FlgII-28 in Solanum lycopersicum: intracellular perturbations and metabolite defenses

open access: yesBMC Plant Biology, 2021
Background Surveillance of potential pathogens is a key feature of plant innate immunity. For non-self-recognition plants rely on the perception of pathogen-derived molecules.
Dylan R. Zeiss   +3 more
doaj   +1 more source

Sialic acid linkage differentiation of glycopeptides using capillary electrophoresis – electrospray ionization – mass spectrometry

open access: yesScientific Reports, 2017
Sialylation is a glycosylation feature that occurs in different linkages at the non-reducing end of a glycan moiety, the linkage isomers are often differentially associated with various biological processes.
Guinevere S. M. Kammeijer   +7 more
doaj   +1 more source

Aromatic amino acids play a harmonizing role in prostate cancer: A metabolomics-based cross-sectional study

open access: yesInternational Journal of Reproductive BioMedicine, 2021
Background: Prostate cancer (PCa) is a common health problem worldwide. The rate of this disease is likely to grow by 2021. PCa is a heterogeneous disorder, and various biochemical factors contribute to the development of this disease.
Ziba Akbari   +4 more
doaj   +1 more source

Lipidomic Signatures of Changes in Adiposity: A Large Prospective Study of 5849 Adults from the Australian Diabetes, Obesity and Lifestyle Study

open access: yesMetabolites, 2021
Lipid metabolism is tightly linked to adiposity. Comprehensive lipidomic profiling offers new insights into the dysregulation of lipid metabolism in relation to weight gain.
Habtamu B. Beyene   +9 more
doaj   +1 more source

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