Results 11 to 20 of about 799,271 (304)
Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review
Frontiers in Oncology, 2023 Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable ...
Xian-Wen Liang +7 more
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Emerging Microbes and Infections, 2020 Bacterial persistence is one of the major causes of antibiotic treatment failure and the step stone for antibiotic resistance. However, the mechanism by which persisters arise has not been well understood.
Jin Zou +6 more
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Frontiers in Pharmacology, 2022 The latest consensus has changed CYP2D6 genotyping among Chinese population, while its impact on metoprolol tolerance and adverse events in elderly Chinese patients with cardiovascular diseases remains unclear.
Jianqiao Chen +14 more
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eLife, 2023 Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C.
Vanessa Dumeaux +12 more
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Frontiers in Microbiology, 2020 The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M. tuberculosis genome.
Arun Sharma +10 more
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Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years
Frontiers in Pediatrics, 2021 Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce.
Justyna Sieber +4 more
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Frontiers in Cellular and Infection Microbiology, 2023 IntroductionResistance against anti-Leishmania drugs (DR) has been studied for years, giving important insights into long-term adaptations of these parasites to drugs, through genetic modifications.
Marlene Jara +6 more
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Image-based dynamic phenotyping reveals genetic determinants of filamentation-mediated beta-lactam tolerance [PDF]
, 2020 Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance.
Camacho, Rafael +8 more
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Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans
Frontiers in Microbiology, 2020 Candida albicans is an important human pathogen and a major concern in intensive care units around the world. C. albicans infections are associated with a high mortality despite the use of antifungal treatments.
Eric Delarze +13 more
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The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer
Frontiers in Genetics, 2023 Ovarian cancer affects the female reproductive system and is the primary cause of cancer related mortality globally. The imprecise and non-specific nature of ovarian cancer symptoms often results in patients being diagnosed at an advanced stage, with ...
Biqing Chen +3 more
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