Results 11 to 20 of about 2,744,410 (300)

The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis. [PDF]

mBio, 2022
Mycobacterium tuberculosis can cocatabolize a range of carbon sources.Fatty acids are among the carbons available inside the host’s macrophages. Here, we investigated the metabolic changes of the fatty acid-induced dormancy-like state of M.
Quinonez CG, Lee JJ, Lim J, Odell M, Lawson CP, Anyogu A, Raheem S, Eoh H.   +7 more
europepmc   +6 more sources

The Mycobacterium bovis BCG GroEL1 Contributes to Isoniazid Tolerance in a Dormant-Like State Model

Microorganisms, 2023
Due to the Mycobacterium tuberculosis complex, including M. tuberculosis and M. bovis, tuberculosis still causes 1.6 million deaths per year. Therefore, efforts to improve tuberculosis treatment are necessary. We previously showed that the GroEL1 protein
Sheng Zeng, Dong Yang, Céline Rens, Véronique Fontaine   +3 more
doaj   +1 more source

Clinical study of dynamic changes of cerebrospinal fluid cytology in drug resistant tuberculous meningitis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To summarize the dynamic changes of cerebrospinal fluid (CSF) cytology in drug resistant tuberculous meningitis (TBM), and to explore its value in drug resistance and efficacy evaluation of TBM.
CAO Dong⁃dong, KUANG Wei⁃feng , ZHANG Li⁃ting, ZHOU Li, ZHAO Si⁃qi , DUAN Hong⁃fei, XIE Jia , JIN Yan , CHEN Hai⁃ying , YE Lin , ZHANG Qi⁃long   +10 more
doaj   +1 more source

Tools to develop antibiotic combinations that target drug tolerance in <i>Mycobacterium tuberculosis</i>. [PDF]

Front Cell Infect Microbiol, 2022
Combination therapy is necessary to treat tuberculosis to decrease the rate of disease relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently needed.
Greenstein T, Aldridge BB.
europepmc   +2 more sources

The Resolution of the Russian League Against Epilepsy Working Group Meeting (September 25, 2021, Moscow)

Эпилепсия и пароксизмальные состояния, 2022
On September 25, 2021, the Russian League Against Epilepsy (RLAE) Working Group Meeting was held regarding approaches to therapy of pediatric focal epilepsy.
article Editorial
doaj   +1 more source

Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings

Veterinary Sciences, 2022
Differences in drug tolerability among vertebrate groups and species can create substantial challenges for wildlife and ex situ conservation programmes.
Anja Wiegmann, Tony Rinaud, Meinolf Ottensmann, Oliver Krüger, Andrea Springer, Marko Legler, Michael Fehr, Christina Strube, Nayden Chakarov   +8 more
doaj   +1 more source

Mycobacterium tuberculosis Requires the Outer Membrane Lipid Phthiocerol Dimycocerosate for Starvation-Induced Antibiotic Tolerance

mSystems, 2023
Tolerance of Mycobacterium tuberculosis to antibiotics contributes to the long duration of tuberculosis (TB) treatment and the emergence of drug-resistant strains. M.
Alisha M. Block, Sarah B. Namugenyi, Nagendra P. Palani, Alyssa M. Brokaw, Leanne Zhang, Kenneth B. Beckman, Anna D. Tischler   +6 more
doaj   +1 more source

Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review

Frontiers in Oncology, 2023
Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable ...
Xian-Wen Liang, Bing- Liu, Jia-Cheng Chen, Zhi Cao, Feng-ran Chu, Xiong Lin, Sheng-Zhong Wang, Jin-Cai Wu   +7 more
doaj   +1 more source

Non-walled spherical Acinetobacter baumannii is an important type of persister upon β-lactam antibiotic treatment

Emerging Microbes and Infections, 2020
Bacterial persistence is one of the major causes of antibiotic treatment failure and the step stone for antibiotic resistance. However, the mechanism by which persisters arise has not been well understood.
Jin Zou, Si-Hoi Kou, Ruiqiang Xie, Michael S. VanNieuwenhze, Jiuxin Qu, Bo Peng, Jun Zheng   +6 more
doaj   +1 more source

Impact of the CYP2D6 Genotype on Metoprolol Tolerance and Adverse Events in Elderly Chinese Patients With Cardiovascular Diseases

Frontiers in Pharmacology, 2022
The latest consensus has changed CYP2D6 genotyping among Chinese population, while its impact on metoprolol tolerance and adverse events in elderly Chinese patients with cardiovascular diseases remains unclear.
Jianqiao Chen, Jianqiao Chen, Jin Zheng, Zifan Zhu, Zifan Zhu, Benchuan Hao, Benchuan Hao, Miao Wang, Huiying Li, Huiying Li, Yulun Cai, Yulun Cai, Shiqi Wang, Jun Li, Hongbin Liu   +14 more
doaj   +1 more source