Results 11 to 20 of about 411,089 (301)
Understanding the contribution of metabolism to Mycobacterium tuberculosis drug tolerance. [PDF]
Front Cell Infect Microbiol, 2022 Treatment of Mycobacterium tuberculosis (Mtb) infections is particularly arduous. One challenge to effectively treating tuberculosis is that drug efficacy in vivo often fails to match drug efficacy in vitro.
Samuels AN +4 more
europepmc +3 more sources
mSystems, 2023 Tolerance of Mycobacterium tuberculosis to antibiotics contributes to the long duration of tuberculosis (TB) treatment and the emergence of drug-resistant strains. M.
Alisha M. Block +6 more
doaj +1 more source
Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review
Frontiers in Oncology, 2023 Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable ...
Xian-Wen Liang +7 more
doaj +1 more source
Emerging Microbes and Infections, 2020 Bacterial persistence is one of the major causes of antibiotic treatment failure and the step stone for antibiotic resistance. However, the mechanism by which persisters arise has not been well understood.
Jin Zou +6 more
doaj +1 more source
Frontiers in Pharmacology, 2022 The latest consensus has changed CYP2D6 genotyping among Chinese population, while its impact on metoprolol tolerance and adverse events in elderly Chinese patients with cardiovascular diseases remains unclear.
Jianqiao Chen +14 more
doaj +1 more source
eLife, 2023 Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C.
Vanessa Dumeaux +12 more
doaj +1 more source
Frontiers in Microbiology, 2020 The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M. tuberculosis genome.
Arun Sharma +10 more
doaj +1 more source
Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years
Frontiers in Pediatrics, 2021 Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce.
Justyna Sieber +4 more
doaj +1 more source
The proteasome regulator Rpn4 controls antifungal drug tolerance by coupling protein homeostasis with metabolic responses to drug stress. [PDF]
PLoS Pathog, 2023 Fungal pathogens overcome antifungal drug therapy by classic resistance mechanisms, such as increased efflux or changes to the drug target. However, even when a fungal strain is susceptible, trailing or persistent microbial growth in the presence of an ...
Yau KPS +7 more
europepmc +2 more sources
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionResistance against anti-Leishmania drugs (DR) has been studied for years, giving important insights into long-term adaptations of these parasites to drugs, through genetic modifications.
Marlene Jara +6 more
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