Drug resistance and tolerance in fungi
Nature Reviews Microbiology, 2020 Systemic fungal infections pose a serious clinical problem. Treatment options are limited, and antifungal drug resistance is increasing. In addition, a substantial proportion of patients do not respond to therapy despite being infected with fungi that are susceptible to the drug.
J. Berman, D. Krysan
semanticscholar +6 more sources
Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in Mycobacterium tuberculosis. [PDF]
PLoS Pathog, 2022 Despite the existence of well-characterized, canonical mutations that confer high-level drug resistance to Mycobacterium tuberculosis (Mtb), there is evidence that drug resistance mechanisms are more complex than simple acquisition of such mutations ...
Martini MC +7 more
europepmc +2 more sources
Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance. [PDF]
Nat Commun, 2022 Mechanisms of drug-tolerance remain poorly understood and have been linked to genomic but also to non-genomic processes. 5-fluorouracil (5-FU), the most widely used chemotherapy in oncology is associated with resistance.
Therizols G +31 more
europepmc +2 more sources
Frontiers in Microbiology, 2020 The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M. tuberculosis genome.
Arun Sharma +10 more
doaj +2 more sources
Tunicamycin Potentiates Antifungal Drug Tolerance via Aneuploidy in Candida albicans. [PDF]
mBio, 2021 Candida albicans is a prevalent human fungal commensal and also a pathogen that causes life-threatening systemic infections. Treatment failures are frequent because few therapeutic antifungal drug classes are available and because drug resistance and ...
Yang F +7 more
europepmc +2 more sources
Drug Tolerance to EGFR Tyrosine Kinase Inhibitors in Lung Cancers with EGFR Mutations. [PDF]
Cells, 2021 Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) serve as the standard of care for the first-line treatment of patients with lung cancers with EGFR-activating mutations.
Suda K, Mitsudomi T.
europepmc +2 more sources
Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of Mycobacterium tuberculosis in hypoxia. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Nonreplicating (NR) Mycobacterium tuberculosis (Mtb) was thought to be drug tolerant due to its low metabolic activity. However, drug tolerance often gradually increases by exposure to antibiotics, inferring the role of an adaptive strategy.
Lim J +5 more
europepmc +2 more sources
Ketoconazole induces reversible antifungal drug tolerance mediated by trisomy of chromosome R in Candida albicans [PDF]
Frontiers in MicrobiologyBackgroundThe emergence of tolerance to antifungal agents in Candida albicans complicates the treatment of fungal infections. Understanding the mechanisms underlying this tolerance is crucial for developing effective therapeutic strategies.ObjectiveThis ...
Lijun Zheng +3 more
doaj +2 more sources
Cancer Cell, 2016 Summary Once melanomas have progressed with acquired resistance to mitogen-activated protein kinase (MAPK)-targeted therapy, mutational heterogeneity presents a major challenge.
Michael P. Smith +15 more
semanticscholar +3 more sources
The Mycobacterium bovis BCG GroEL1 Contributes to Isoniazid Tolerance in a Dormant-Like State Model
Microorganisms, 2023 Due to the Mycobacterium tuberculosis complex, including M. tuberculosis and M. bovis, tuberculosis still causes 1.6 million deaths per year. Therefore, efforts to improve tuberculosis treatment are necessary. We previously showed that the GroEL1 protein
Sheng Zeng +3 more
doaj +1 more source