Results 31 to 40 of about 5,956,077 (339)
Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years
Frontiers in Pediatrics, 2021 Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce.
Justyna Sieber +4 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionResistance against anti-Leishmania drugs (DR) has been studied for years, giving important insights into long-term adaptations of these parasites to drugs, through genetic modifications.
Marlene Jara +6 more
doaj +1 more source
Antimicrobial Agents and Chemotherapy, 2021 Active efflux of drugs across the membrane is a major survival strategy of bacteria against many drugs. In this work, we characterize an efflux pump, EfpA, from the major facilitator superfamily, that is highly conserved among both slow-growing and fast ...
Deepika Rai, Sarika Mehra
semanticscholar +1 more source
CDK7 and MITF repress a transcription program involved in survival and drug tolerance in melanoma
EMBO Reports, 2021 Melanoma cell phenotype switching between differentiated melanocytic and undifferentiated mesenchymal‐like states drives metastasis and drug resistance. CDK7 is the serine/threonine kinase of the basal transcription factor TFIIH.
Pietro Berico +13 more
semanticscholar +1 more source
Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans
Frontiers in Microbiology, 2020 Candida albicans is an important human pathogen and a major concern in intensive care units around the world. C. albicans infections are associated with a high mortality despite the use of antifungal treatments.
Eric Delarze +13 more
doaj +1 more source
The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer
Frontiers in Genetics, 2023 Ovarian cancer affects the female reproductive system and is the primary cause of cancer related mortality globally. The imprecise and non-specific nature of ovarian cancer symptoms often results in patients being diagnosed at an advanced stage, with ...
Biqing Chen +3 more
doaj +1 more source
Image-based dynamic phenotyping reveals genetic determinants of filamentation-mediated beta-lactam tolerance [PDF]
, 2020 Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance.
Camacho, Rafael +8 more
core +2 more sources
Fatty acid metabolism of Mycobacterium tuberculosis: A double-edged sword
Microbial Cell, 2022 Unlike other heterotrophic bacteria, Mycobacterium tuberculosis (Mtb) can co-catabolize a range of carbon sources simultaneously. Evolution of Mtb within host nutrient environment allows Mtb to consume the host’s fatty acids as a main carbon source ...
Camila G. Quinonez +7 more
doaj +1 more source
Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy [PDF]
, 2013 Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer ...
Chan, Kiat-Hwa +8 more
core +1 more source
Microorganisms, 2023 Mycobacterium abscessus has recently emerged as the cause of an increasing number of human infections worldwide. Unfortunately, it is highly resistant to existing drugs, and new specific agents to combat M. abscessus have not yet been found.
Andrey L. Mulyukin +7 more
doaj +1 more source