Results 31 to 40 of about 2,744,410 (300)

Volumetric fluid analysis of fixed monthly anti-VEGF treatment in patients with neovascular age-related macular degeneration [PDF]

International Journal of Ophthalmology, 2023
AIM: To evaluate visual outcomes and changes in fluid after administering monthly anti-vascular endothelial growth factor (VEGF) injections to treat neovascular age-related macular degeneration (nAMD) with subretinal fluid (SRF) and pigment epithelial ...
Bo Hee Kim, In Boem Chang, Hyeong Gon Yu, In Hwan Hong   +3 more
doaj   +1 more source

Tolerance analysis approach based on the classification of uncertainty (aleatory / epistemic) [PDF]

, 2012
Uncertainty is ubiquitous in tolerance analysis problem. This paper deals with tolerance analysis formulation, more particularly, with the uncertainty which is necessary to take into account into the foundation of this formulation.
Qureshi, A.J., LEMAIRE, Maurice, Etienne, A., DANTAN, Jean-Yves, Gayton, Nicolas, QURESHI, Ahmed Jawad, GAYTON, N., Lemaire, M., ETIENNE, Alain, Dantan, J.Y.   +9 more
core   +1 more source

Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs

eLife, 2020
Previously, we identified long repeat sequences that are frequently associated with genome rearrangements, including copy number variation (CNV), in many diverse isolates of the human fungal pathogen Candida albicans (Todd et al., 2019).
Robert T Todd, Anna Selmecki
doaj   +1 more source

Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation but not anaerobic respiration [PDF]

, 2014
Non-inherited antibiotic resistance is a phenomenon whereby a subpopulation of genetically identical bacteria displays phenotypic tolerance to antibiotics. We show that, compared to E. coli, the clinically relevant genus Burkholderia displays much higher
Butler, Clive S., Titball, Richard W., Andreae, Clio A., Luo, Jamie X., Soyer, Orkun S., Hemsley, Claudia M.   +5 more
core   +1 more source

Hsp21potentiates antifungal drug tolerance in Candida albicans [PDF]

, 2013
Peer ...
Hube Bernhard, Wilson Duncan, Duncan Wilson, Bernhard Hube, Mayer, François L, Hube, Bernhard, Mayer François L., Wilson, Duncan, François L Mayer   +8 more
core   +2 more sources

Decoding drug tolerance: insights into the <i>Rv0274</i> gene's role in isoniazid tolerance. [PDF]

Front Microbiol
IntroductionIsoniazid is widely used in the treatment of pulmonary tuberculosis, yet the mechanisms underlying its tolerance remain incompletely understood.
Li M, Wang Y, Xiang X, Dong L, Li Q, Liu Z, Chu W, Naifang Y, Gong Z, Zhou Q.   +9 more
europepmc   +2 more sources

Resumptive Streptococcus mutans Persisters Induced From Dimethylaminododecyl Methacrylate Elevated the Cariogenic Virulence by Up-Regulating the Quorum-Sensing and VicRK Pathway Genes

Frontiers in Microbiology, 2020
Bacterial persistence has become a worldwide health problem due to its ability to cause the recalcitrance and relapse of infections. The existence of bacterial persistence and their possible mechanisms have been widely reported.
Junzhuo Lu, Lei Cheng, Yuyao Huang, Yaling Jiang, Chun-Hung Chu, Xian Peng, Mingyun Li, Hockin H. K. Xu, Xuedong Zhou, Biao Ren   +9 more
doaj   +1 more source

The Tricalbin-Family Endoplasmic Reticulum-Plasma Membrane Tethering Proteins Attenuate ROS-Involved Caspofungin Sensitivity in Candida albicans

Microbiology Spectrum, 2022
The endoplasmic reticulum-plasma membrane (ER-PM) contacts are one kind of important membrane contact structures in eukaryotic cells, which mediate material and message exchange between the ER and the PM.
Li Yang, Hangqi Zhu, Mingchun Li, Qilin Yu   +3 more
doaj   +1 more source

Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells

Frontiers in Oncology, 2022
BackgroundDespite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives therapy failure and tumor relapse.
Xiaoli Zhang, Xiaoli Zhang, Xiaoli Zhang, Yiming Ma, Jianhui Ma, Lan Yang, Qingzhi Song, Hongying Wang, Guoqing Lv   +8 more
doaj   +1 more source

Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis

eLife, 2017
Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams.
Saurabh Mishra, Prashant Shukla, Ashima Bhaskar, Kushi Anand, Priyanka Baloni, Rajiv Kumar Jha, Abhilash Mohan, Raju S Rajmani, Valakunja Nagaraja, Nagasuma Chandra, Amit Singh   +10 more
doaj   +1 more source