Results 31 to 40 of about 799,271 (304)

Depth of anesthesia control using internal model control techniques [PDF]

, 2010
The major difficulty in the design of closed-loop control during anaesthesia is the inherent patient variability due to differences in demographic and drug tolerance.
Anna, Shahab, Wen, Peng
core   +2 more sources

Ethanol reversal of tolerance to the respiratory depressant effects of morphine [PDF]

, 2015
Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different ...
A Fugelstad, A Fugelstad, Abi Lyndon, AJ Ruttenber, Anne Lingford-Hughes, AR Lingford-Hughes, B Levine, BM Mathers, CA Paronis, Chris Bailey, CK Kuo, CN Lessov, CP Bailey, CP Bailey, CP Bailey, E Kelly, E Valjent, Eamonn Kelly, EB Rex, EJ Waite, F Chen, FL Smith, FL Smith, Graeme Henderson, GS Ling, H Sakakibara, HW Matthes, HY Lin, I Rodriguez-Martin, J Llorente, J McPherson, J Reneau, JM White, Joanne Roberts, John MacLachlan, JT Williams, JW Lewis, KL McGilliard, L He, LC Hull, LC Saland, LJ Sim-Selley, LM Bohn, LQ Hong-Brown, M Aliczki, M Hickman, M Hickman, M Inoue, M Pierce, Matthew Hickman, N Quillinan, NG Shah, R Cornish, R Romberg, Rob Hill, S Darke, S Darke, S Kishioka, Sarah Withey, SJ Slater, SV Dighe, TC Green, Yvonne Kershaw   +62 more
core   +5 more sources

Resumptive Streptococcus mutans Persisters Induced From Dimethylaminododecyl Methacrylate Elevated the Cariogenic Virulence by Up-Regulating the Quorum-Sensing and VicRK Pathway Genes

Frontiers in Microbiology, 2020
Bacterial persistence has become a worldwide health problem due to its ability to cause the recalcitrance and relapse of infections. The existence of bacterial persistence and their possible mechanisms have been widely reported.
Junzhuo Lu, Lei Cheng, Yuyao Huang, Yaling Jiang, Chun-Hung Chu, Xian Peng, Mingyun Li, Hockin H. K. Xu, Xuedong Zhou, Biao Ren   +9 more
doaj   +1 more source

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. [PDF]

, 2019
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. Tumor relapse following chemotherapy treatment has long been a significant challenge towards completely curing cancer.
de Vere White, Ralph, Ghosh, Paramita M, He, Wei, Hum, Nicholas R, Loots, Gabriela G, Martin, Kelly A, Pan, Chong-Xian, Sebastian, Aimy, Siddiqui, Salma   +8 more
core   +2 more sources

The Tricalbin-Family Endoplasmic Reticulum-Plasma Membrane Tethering Proteins Attenuate ROS-Involved Caspofungin Sensitivity in Candida albicans

Microbiology Spectrum, 2022
The endoplasmic reticulum-plasma membrane (ER-PM) contacts are one kind of important membrane contact structures in eukaryotic cells, which mediate material and message exchange between the ER and the PM.
Li Yang, Hangqi Zhu, Mingchun Li, Qilin Yu   +3 more
doaj   +1 more source

Post-mortem toxicology: A pilot study to evaluate the use of a Bayesian network to assess the likelihood of fatality [PDF]

, 2015
The challenge of interpreting post-mortem drug concentrations is well documented and relies on appropriate sample collection, knowledge of case circumstances as well as reference to published tables of data, whilst taking into account the known issues of
Bolton, Jennifer, Carlin, Michelle, Langford, Alan, Palmer, Ray   +3 more
core   +1 more source

Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells

Frontiers in Oncology, 2022
BackgroundDespite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives therapy failure and tumor relapse.
Xiaoli Zhang, Xiaoli Zhang, Xiaoli Zhang, Yiming Ma, Jianhui Ma, Lan Yang, Qingzhi Song, Hongying Wang, Guoqing Lv   +8 more
doaj   +1 more source

Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. [PDF]

, 2019
Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance.
A Hübner, AB D’Assoro, AJ Lee, AN Hata, Andrei Goga, Andrew D. Simmons, Angel Ku, AS Nikonova, Ashley Maynard, B Melichar, CA Eberlein, CK Lee, CM Blakely, CM Blakely, Collin M. Blakely, D Ercan, DB Costa, F Varghese, Frank McCormick, Golzar Hemmati, Gregor Krings, Hayley J. Donnella, Henry J. Haringsma, J Chen, J Fu, Jacqueline Galeas, JJ Chabon, Jonathan Kuhn, Julia Rohrberg, Julia Rotow, K Shien, Khyati N. Shah, KS Thress, L Li, Liliane Robillard, LV Sequist, LV Sequist, M Moustafa-Kamal, M Ramirez, Maria M. Martins, MJ Niederst, MS Cragg, MW Karaman, OJ Gruss, PA Jänne, R Rosell, RA Burrell, Roma Bhatt, S Anand, S Stewart, Sophie Dumont, Sourav Bandyopadhyay, SV Sharma, Swati Kaushik, T Sharifnia, TC Chou, TG Bivona, TG Bivona, Thomas C. Harding, TM Kim, Trever G. Bivona, V Bavetsias, Victor Olivas, Victoria E. Wang, Y Zhou, Z Piotrowska, Z Yang   +66 more
core   +1 more source

Persister cells as a possible cause of antibiotic therapy failure in Helicobacter pylori

JGH Open, 2021
Background and Aim Due to the failure of antibiotic treatment and recurrence of infection in patients with Helicobacter pylori, this study was designed to find the possible cause of treatment failure and recurrence of the H.
Parvin Bahmaninejad, Sobhan Ghafourian, Mina Mahmoudi, Abbas Maleki, Nourkhoda Sadeghifard, Behzad Badakhsh   +5 more
doaj   +1 more source

Hsp21potentiates antifungal drug tolerance in Candida albicans [PDF]

, 2013
Peer reviewedPublisher ...
Alix Therese Coste, B Enjalbert, B Enjalbert, B Wachtler, Bernhard Hube, C Fradin, C Onyewu, C Onyewu, D Harcus, Duncan Wilson, F Abe, F Ritossa, FL Mayer, François L. Mayer, G Kappe, H Senn, HJ Lo, ID Jacobsen, J Buchner, JA Lewis, K Richter, K Zakikhany, L Whitesell, LE Cowen, LE Cowen, LE Cowen, LE Cowen, LE Cowen, M Lis, M Ramsdale, M Taipale, M Taipale, MA Pfaller, MA Pfaller, MC Cruz, MC Lorenz, MS Fu, N Booth, N Robbins, P Uppuluri, RK Swoboda, RS Shapiro, RS Shapiro, RS Shapiro, RS Shapiro, S Diezmann, S Hodgetts, S Lindquist, S Nicholls, S Thewes, SD Singh, SL LaFayette, WJ Steinbach   +52 more
core   +2 more sources