Results 31 to 40 of about 2,900,874 (198)

The Tricalbin-Family Endoplasmic Reticulum-Plasma Membrane Tethering Proteins Attenuate ROS-Involved Caspofungin Sensitivity in Candida albicans

Microbiology Spectrum, 2022
The endoplasmic reticulum-plasma membrane (ER-PM) contacts are one kind of important membrane contact structures in eukaryotic cells, which mediate material and message exchange between the ER and the PM.
Li Yang, Hangqi Zhu, Mingchun Li, Qilin Yu   +3 more
doaj   +1 more source

Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis

eLife, 2017
Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams.
Saurabh Mishra, Prashant Shukla, Ashima Bhaskar, Kushi Anand, Priyanka Baloni, Rajiv Kumar Jha, Abhilash Mohan, Raju S Rajmani, Valakunja Nagaraja, Nagasuma Chandra, Amit Singh   +10 more
doaj   +1 more source

Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells

Frontiers in Oncology, 2022
BackgroundDespite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives therapy failure and tumor relapse.
Xiaoli Zhang, Xiaoli Zhang, Xiaoli Zhang, Yiming Ma, Jianhui Ma, Lan Yang, Qingzhi Song, Hongying Wang, Guoqing Lv   +8 more
doaj   +1 more source

Persister cells as a possible cause of antibiotic therapy failure in Helicobacter pylori

JGH Open, 2021
Background and Aim Due to the failure of antibiotic treatment and recurrence of infection in patients with Helicobacter pylori, this study was designed to find the possible cause of treatment failure and recurrence of the H.
Parvin Bahmaninejad, Sobhan Ghafourian, Mina Mahmoudi, Abbas Maleki, Nourkhoda Sadeghifard, Behzad Badakhsh   +5 more
doaj   +1 more source

In vivo laboratory practicals in research-led teaching: An example using glucose tolerance tests in lean and obese mice [PDF]

, 2011
The use of animal models is an essential part of medical research and drug development. The essential skills required to be able to do such research includes experimental design, statistical analysis and the actual handling and treating of the animals ...
Ian M. Kinchin, Sprake, J.A, Sprake, Juliet, King, Aileen, Juliet A. Sprake, Bowe, James, King, A; id_orcid, James E. Bowe, Bowe, J, Kinchin, I.M, Aileen J.F. King   +10 more
core   +1 more source

Tolerability of Antimalaria Drugs [PDF]

Clinical Infectious Diseases, 2002
Sir—The multicenter randomized trial reported by Overbosch and colleagues [1] is important for 2 reasons. First, the study shows that when taken as malaria prophylaxis, mefloquine is not well tolerated by many travelers. Of the study participants randomized to receive mefloquine, 67.1% reported 1 adverse event, and, in 6% of mefloquine users, these ...
Ashley M. Croft, Andrew Herxheimer
openaire   +1 more source

Amphetamine and pseudoephedrine cross-tolerance measured by c-Fos protein expression in brains of chronically treated rats [PDF]

, 2008
Background Pseudoephedrine is a drug commonly prescribed as a nasal decongestant and bronchodilator and is also freely available in cold remedies and medications.
Tongjaroenbuangam, W., Nootchanart Ruksee, Govitrapong, P., Casalotti Stefano O, Ruksee Nootchanart, Walaiporn Tongjaroenbuangam, Nootchanart Ruksee, Govitrapong Piyarat, Casalotti, Stefano O., Ruksee, N., Piyarat Govitrapong, Tongjaroenbuangam Walaiporn, Stefano O Casalotti   +12 more
core   +1 more source

Induction of Aspergillus fumigatus zinc cluster transcription factor OdrA/Mdu2 provides combined cellular responses for oxidative stress protection and multiple antifungal drug resistance

mBio, 2023
Zinc cluster transcription factors (Zcfs) encoding zcf genes are exclusive for fungi and required for multiple cellular processes including metabolism and development.
Christoph Sasse, Emmanouil Bastakis, Fruzsina Bakti, Annalena M. Höfer, Isabella Zangl, Christoph Schüller, Anna M. Köhler, Jennifer Gerke, Sven Krappmann, Florian Finkernagel, Rebekka Harting, Joseph Strauss, Kai Heimel, Gerhard H. Braus   +13 more
doaj   +1 more source

The processes of reform in Victoria’s alcohol and other drug sector, 2011-2014 [PDF]

, 2014
This paper explores issues and concerns related to the 2014 alcohol and other drug sector recommissioning process in Victoria. Overview In mid-2014, the Victorian Alcohol and Drug Association approached the Drug Policy Modelling Program, at the ...
Drug Policy Modelling Program
core  

Drug-Tolerant Idling Melanoma Cells Exhibit Theory-Predicted Metabolic Low-Low Phenotype

Frontiers in Oncology, 2020
Cancer cells adjust their metabolic profiles to evade treatment. Metabolic adaptation is complex and hence better understood by an integrated theoretical-experimental approach. Using a minimal kinetic model, we predicted a previously undescribed Low/Low (
Dongya Jia, B. Bishal Paudel, B. Bishal Paudel, B. Bishal Paudel, Corey E. Hayford, Corey E. Hayford, Corey E. Hayford, Keisha N. Hardeman, Keisha N. Hardeman, Herbert Levine, Herbert Levine, Herbert Levine, José N. Onuchic, José N. Onuchic, José N. Onuchic, José N. Onuchic, Vito Quaranta, Vito Quaranta   +17 more
doaj   +1 more source