Results 31 to 40 of about 411,089 (301)

Chromametric assessment of drug skin tolerance: A comparative study between Africans and Caucasians skins. [PDF]

open access: yes, 2020
BACKGROUND/AIMS: During dermatological forms development, one of the simplest non-invasive techniques used to evaluate cutaneous tolerance of formulations is to monitor the color changes using a tristimulus chromameter.
Piel, Géraldine   +13 more
core   +1 more source

Pavlovian-conditioned opioid tolerance. [PDF]

open access: yes, 2023
Opioid tolerance develops as a learned response to drug-associated cues and is thus a dynamic effect modulated by the interaction between drug and ...
Siciliano, Cody A, Farahbakhsh, Zahra Z
core   +1 more source

Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs

open access: yeseLife, 2020
Previously, we identified long repeat sequences that are frequently associated with genome rearrangements, including copy number variation (CNV), in many diverse isolates of the human fungal pathogen Candida albicans (Todd et al., 2019).
Robert T Todd, Anna Selmecki
doaj   +1 more source

Identification and Elimination of Antifungal Tolerance in Candida auris [PDF]

open access: yes, 2023
Antimicrobial resistance is a global health crisis to which pathogenic fungi make a substantial contribution. The human fungal pathogen C. auris is of particular concern due to its rapid spread across the world and its evolution of multidrug resistance ...
Daniel A. Charlebois   +3 more
core   +1 more source

In vivo laboratory practicals in research-led teaching: An example using glucose tolerance tests in lean and obese mice [PDF]

open access: yes, 2011
The use of animal models is an essential part of medical research and drug development. The essential skills required to be able to do such research includes experimental design, statistical analysis and the actual handling and treating of the animals ...
Ian M. Kinchin   +10 more
core   +1 more source

Resumptive Streptococcus mutans Persisters Induced From Dimethylaminododecyl Methacrylate Elevated the Cariogenic Virulence by Up-Regulating the Quorum-Sensing and VicRK Pathway Genes

open access: yesFrontiers in Microbiology, 2020
Bacterial persistence has become a worldwide health problem due to its ability to cause the recalcitrance and relapse of infections. The existence of bacterial persistence and their possible mechanisms have been widely reported.
Junzhuo Lu   +9 more
doaj   +1 more source

Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs) : a systematic structured review of the literature [PDF]

open access: yes, 2007
Adverse events triggered by non-steroidal anti-inflammatory drugs (NSAIDs) are among the most common drug-related intolerance reactions in medicine; they are possibly related to inhibition of cyclooxygenase-1.
Weberschock, Tobias Bernd Bernd   +8 more
core   +1 more source

The Tricalbin-Family Endoplasmic Reticulum-Plasma Membrane Tethering Proteins Attenuate ROS-Involved Caspofungin Sensitivity in Candida albicans

open access: yesMicrobiology Spectrum, 2022
The endoplasmic reticulum-plasma membrane (ER-PM) contacts are one kind of important membrane contact structures in eukaryotic cells, which mediate material and message exchange between the ER and the PM.
Li Yang   +3 more
doaj   +1 more source

Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells

open access: yesFrontiers in Oncology, 2022
BackgroundDespite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives therapy failure and tumor relapse.
Xiaoli Zhang   +8 more
doaj   +1 more source

Persister cells as a possible cause of antibiotic therapy failure in Helicobacter pylori

open access: yesJGH Open, 2021
Background and Aim Due to the failure of antibiotic treatment and recurrence of infection in patients with Helicobacter pylori, this study was designed to find the possible cause of treatment failure and recurrence of the H.
Parvin Bahmaninejad   +5 more
doaj   +1 more source

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