Observational multicenter study of efficacy of paroxetine film-coated tablet in the treatment of anxiety disorder [PDF]
Medicinski Glasnik, 2018 Aim To examine the efficiency of paroxetine treatment of anxiety disorders in adult patients over the period of 12 months and the improvement of symptoms of anxiety disorder during this period, as well as to examine the tolerability of the administered ...
Alma Džubur Kulenović +7 more
doaj +1 more source
Tolerability of Antimalaria Drugs [PDF]
Clinical Infectious Diseases, 2002 Sir—The multicenter randomized trial reported by Overbosch and colleagues [1] is important for 2 reasons. First, the study shows that when taken as malaria prophylaxis, mefloquine is not well tolerated by many travelers. Of the study participants randomized to receive mefloquine, 67.1% reported 1 adverse event, and, in 6% of mefloquine users, these ...
Ashley M. Croft, Andrew Herxheimer
openaire +1 more source
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. [PDF]
, 2019 Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance.
A Hübner +66 more
core +1 more source
mGluR5 Negative Modulators for Fragile X: Treatment Resistance and Persistence
Frontiers in Psychiatry, 2021 Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate ...
David C. Stoppel +4 more
doaj +1 more source
Post-mortem toxicology: A pilot study to evaluate the use of a Bayesian network to assess the likelihood of fatality [PDF]
, 2015 The challenge of interpreting post-mortem drug concentrations is well documented and relies on appropriate sample collection, knowledge of case circumstances as well as reference to published tables of data, whilst taking into account the known issues of
Bolton, Jennifer +3 more
core +1 more source
Hsp21potentiates antifungal drug tolerance in Candida albicans [PDF]
, 2013 Peer reviewedPublisher ...
Alix Therese Coste +52 more
core +2 more sources
eLife, 2017 Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams.
Saurabh Mishra +10 more
doaj +1 more source
Cells, 2022 Mesenchymal stem cells (MSCs) or fibroblasts are one of the most abundant cell types in the tumor microenvironment (TME) exerting various anti- and pro-apoptotic effects during tumorigenesis, invasion, and drug treatment.
Flóra Vajda +9 more
doaj +1 more source
Volumetric fluid analysis of fixed monthly anti-VEGF treatment in patients with neovascular age-related macular degeneration [PDF]
International Journal of Ophthalmology, 2023 AIM: To evaluate visual outcomes and changes in fluid after administering monthly anti-vascular endothelial growth factor (VEGF) injections to treat neovascular age-related macular degeneration (nAMD) with subretinal fluid (SRF) and pigment epithelial ...
Bo Hee Kim +3 more
doaj +1 more source
Characterization of HSP90 isoforms in transformed bovine leukocytes infected with Theileria annulata [PDF]
, 2016 HSP90 chaperones are essential regulators of cellular function, as they ensure the appropriate conformation of multiple key client proteins. Four HSP90 isoforms were identified in the protozoan parasite Theileria annulata.
Calder, Ewen D.D. +8 more
core +2 more sources